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Agglutinin alpha chain

Summary

Lectin Name Aliases

Artocarpus Integrifolia Agglutinin
Jacalin
jacalin

Monosaccharide Specificities

Organism

Artocarpus integer

External Links

UniProt

P18670

LfDB

LfDB0146

UniLectin

P18670

CarboGrove

Annotation

Keyword

3D-structure
Direct protein sequencing
Glycoprotein
IgA-binding protein
Lectin
Repeat

Gene Ontology (GO)

Displaying **all 2** entries
GO Term
carbohydrate binding
IgA binding

Annotation information from UniProt.

Reference

Displaying entries **1 - 10** of 22 in total

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PubMed ID	Title	First Author
1577729	Thermodynamic and kinetic studies on the mechanism of binding of methylumbelliferyl glycosides to jacalin.	Gupta D
7680651	Isolation and characterization of cDNA clones encoding jacalin isolectins.	Yang H
9497359	Structure of the complex of Maclura pomifera agglutinin and the T-antigen disaccharide, Galbeta1,3GalNAc.	Lee X
9884407	Structural requirements of carbohydrates to bind Agaricus bisporus lectin.	Irazoqui FJ
10910971	Characterization of the rabbit homolog of human MUC1 glycoprotein isolated from bladder by affinity chromatography on immobilized jacalin.	Higuchi T
10837488	Plasticity in the primary binding site of galactose/N-acetylgalactosamine-specific lectins. Implication of the C-H...O hydrogen bond at the specificity-determining C-4 locus of the saccharide in 4-methoxygalactose recognition by jacalin and winged bean (basic) agglutinin I.	Swaminathan CP
12538584	Purification, characterization, molecular cloning, and expression of novel members of jacalin-related lectins from rhizomes of the true fern Phlebodium aureum (L) J. Smith (Polypodiaceae).	Tateno H
12952987	Core 1 glycans on alpha-dystroglycan mediate laminin-induced acetylcholine receptor clustering but not laminin binding.	McDearmon EL
14561768	The crystal structure of the Calystegia sepium agglutinin reveals a novel quaternary arrangement of lectin subunits with a beta-prism fold.	Bourne Y
15247276	Protein phosphatase 2A, a negative regulator of the ERK signaling pathway, is activated by tyrosine phosphorylation of putative HLA class II-associated protein I (PHAPI)/pp32 in response to the antiproliferative lectin, jacalin.	Yu LG

Lectin Frontier DataBase (LfDB)

GlyTouCan: G19083SI
V-V₀: 50.79

GlyTouCan: G62167DK
V-V₀: 45.44

GlyTouCan: G83131MU
V-V₀: 44.29

LfDB provides quantitative interaction data in terms of the affinity constants (K_a) of a series of lectins toward a panel of pyridylaminated (PA) glycans obtained by an automated frontal affinity chromatography with fluorescence detection (FAC-FD) system. Since the data are accurate and reliable, providing the absolute values of sugar-protein interactions, LfDB would be a valuable resource in the studies of glycan-related biology.

The MCAW profile of the top three glycans above, which resulted from FAC analysis.

UniLectin

UniProt
P18670

CarboGrove

Lectin Name: Artocarpus Integrifolia Agglutinin
Common Name: Jacalin

Automated Analysis report (Top 10 high affinity glycans)

Array Source

CFG

Protein Source

Vector

Concentration (ug/mL)

GlyTouCan ID	Binding Intensity	Stdev
G00035MO	973.09	32.23
G32723SL	924.53	41.17
G26166QH	792.53	66.23
G76607YV	543.61	17.8
G76355TG	455.82	37.17
G75472OU	419.92	8.11
G57321FI	401.46	4.71
G00031MO	401.02	137.07
G00035MO	390.14	27.47
G97763JB	373.47	9.76

GlyTouCan ID	Binding Intensity	Stdev
G65562ZE	40277.82	2014.56
G26166QH	36580.89	323.38
G75472OU	36553.51	1080.19
G00031MO	36337.1	632.92
G77477NL	35996.59	2583.39
G65562ZE	34227.09	2033.91
G76355TG	33974.96	1196.27
G32723SL	33173.54	350.21
G00035MO	32958.7	809.62
G00035MO	31373.91	1486.2

GlyTouCan ID	Binding Intensity	Stdev
G01801SZ	47815.46	13655.63
G75472OU	46194.58	1124.96
G23438NR	45443.4	12680.72
G97763JB	38540.01	1602.28
G32723SL	38301.36	1321.12
G00035MO	37557	845.17
G77477NL	36997.99	11075.92
G57321FI	36866.7	849.31
G51162XR	36117.79	2526.28
G65562ZE	36107.49	511.44

GlyTouCan ID	Binding Intensity	Stdev
G75472OU	46978.21	2173.63
G77477NL	41438.68	6869.46
G73991ZU	41165.36	10079.52
G92115PW	41162.64	5422.24
G23438NR	40406.36	12010.57
G11647UD	39533.42	6805.28
G01801SZ	39456.16	5100.01
G32723SL	39067.42	2426.95
G97763JB	38683.35	945.39
G65562ZE	38377.72	1290.4

CarboGrove View

Array Source

ZBiotech

Protein Source

Vector

Concentration (ug/mL)

GlyTouCan ID	Binding Intensity	Stdev
G57321FI	31915.83	0
G00031MO	31062.17	0
G88313DY	29717	0
G99315PE	29614.33	0
G94435QH	28848.5	0
G47548GA	27742.33	0
G00035MO	27723	0
G00068MO	27001.17	0
G83950JR	26724	0
G83120FP	25512	0

CarboGrove View

CarboGrove is populated with the results from 35 types of glycan arrays, 13 glycan families, 5 experimental methods, and 19 laboratories or companies by processing and interpreting data from various types of glycan arrays.