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Aggrecan core protein

Summary

Organism: Homo sapiens (human)

External Links

UniProt: P16112

Annotation

Keyword

3D-structure
Alternative splicing
Calcium
Direct protein sequencing
Disease variant
Disulfide bond
Dwarfism
EGF-like domain
Extracellular matrix
Immunoglobulin domain
Lectin
Metal-binding
Proteoglycan
Reference proteome
Repeat
Signal
Sushi

Gene Ontology (GO)

Displaying **all 6** entries
GO Term
positive regulation of neuroblast proliferation
skeletal system development
proteolysis
cell adhesion
central nervous system development
glial cell differentiation

Displaying **all 7** entries
GO Term
Golgi lumen
extracellular region
extracellular space
synapse
collagen-containing extracellular matrix
lysosomal lumen
perineuronal net

Displaying **all 4** entries
GO Term
carbohydrate binding
metal ion binding
extracellular matrix structural constituent
hyaluronic acid binding

Annotation information from UniProt.

Pathway

Displaying **all 7** entries
Pathway Name	Organism
Defective B4GALT1 causes B4GALT1-CDG (CDG-2d)	Homo sapiens
Defective CHST6 causes MCDC1	Homo sapiens
Defective ST3GAL3 causes MCT12 and EIEE15	Homo sapiens
Degradation of the extracellular matrix	Homo sapiens
ECM proteoglycans	Homo sapiens
Keratan sulfate biosynthesis	Homo sapiens
Keratan sulfate degradation	Homo sapiens

MCAW-DB (Glycan Recognition Profile)

MCAW-DB is a database whereby users can view the multiple alignment analysis results obtained from the MCAW tool, which can computationally find common glycan substructures among a group of glycan structures. The data in MCAW-DB are analysis results of glycan array experiments; those glycans having higher binding affinity to glycan binding proteins (GBPs) have been analyzed and can be viewed as “glycan recognition profiles”. Currently, this database provides published analysis results of glycan array data from the Consortium for Functional Glycomics (CFG).