Degradation of the extracellular matrix

Summary
Species
Homo sapiens
Reactome
PubChem
Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.
ElastinCleaved elastinFibrillin 1,2,(3)Cleaved fibrillin 1,2,(3)Fibrillin-1Cleaved fibrillin-1Fibronectin matrixCleaved fibronectin matrixCleaved fibronectin matrix Ala(271)/Val(272)Laminin-5Laminin-5Laminin-10Laminin-10NID1Nidogen-1Nidogen-1ACANAggrecan(17-392)Aggrecan(393-2415)Aggrecan(361-2415)Aggrecan(17-360)H2OACAN(17-375)ACAN(376-2415)BrevicanBrevican(23-395)Brevican(396-911)Brevican(23-360)Brevican(361-911)HSPG2HSPG2(?-4391)HSPG2(22-?)HSPG2LG3DCNDecorinDCNE-cadherin strand dimerCTF1E-cadherin strand dimer fragment 155-700E-cadherin strand dimer fragment 155-750CTF2E-cadherin strand dimer fragment 751-882A2M tetramerAlpha 2-macroglobulin:MMP1, 3, 13, (2, 7-12, 19)MMP1, 3, 13, (2, 7-12, 19)CD44CD44:MMP2, MMP7, MMP9MMP2, MMP7, MMP9BSGBSG:MMP1(100-469)MMP1SPP1SPP1(17-?)SPP1(?-314)substrate protein for calpainscalpain-cleaved proteinOPTCOpticinOpticinOpticinOpticinOpticinOpticinSCUBE3SCUB3_HUMANSCUB3_HUMANSCUBE1,SCUBE3SCUBE1,SCUBE3 polymer, SCUBE3 polymer
ProteinProtein familyDNARNAComplexChemical/MoleculePhenotype/StimulusNucleusMitochondriaEndosomeGolgi apparatusLysosomeMembraneUp-regulatesDown-regulatesPhysical interactionUnknownDirectIndirectBindingHighlight
Displaying entries 1 - 10 of 60 in total
UniProt ID Protein Name Gene Symbol Pathway Viewer
O14672 Disintegrin and metalloproteinase domain-containing protein 10
  • ADAM10
  • KUZ
  • MADM
view
O15230 Laminin subunit alpha-5
  • KIAA0533
  • KIAA1907
  • LAMA5
view
O43897 Tolloid-like protein 1
  • TLL
  • TLL1
view
O60882 Matrix metalloproteinase-20
  • MMP20
view
O60911 Cathepsin L2
  • CATL2
  • CTSL2
  • CTSU
  • CTSV
view
O75173 A disintegrin and metalloproteinase with thrombospondin motifs 4
  • ADAMTS4
  • KIAA0688
view
O75808 Calpain-15
  • CAPN15
  • SOLH
view
P00747 Plasminogen
  • PLG
view
P01023 Alpha-2-macroglobulin
  • A2M
  • CPAMD5
view
P03956 Interstitial collagenase
  • CLG
  • MMP1
view
Displaying all 3 entries
GlyCosmos Lectin UniProt ID Lectin Name Pathway Viewer
GL_000051 P16112 Aggrecan core protein view
GL_000109 Q96GW7 Brevican core protein view
GL_004606 P35613 Basigin view
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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01


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Last updated: April 7, 2025