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Pathogen Adherence to Carbohydrate Database (PACDB)
PACDB provides the information on pathogens (e.g. bacteria, fungus, toxin and virus) adhering to carbohydrates expressed on the cell surface of host animals or plants.
| Source | Last Updated |
|---|---|
| Pathogen Adherence to Carbohydrate Database (PACDB) | June 1, 2016 |
| Species | Pathogen Adherence Molecule | Ligand Name | Ligand Feature | Target Source ▲ | Glycan Sequence | Binding | PubMed ID |
|---|---|---|---|---|---|---|---|
| Histoplasma capsulatum | Lectin-like component | Galactosylated surface molecules (mainly β-anomer) | Glycoconjugates | Murine macrophages | Binding | 19547878 | |
| Polyoma virus | Unknown | unnamed ligand | Oligosaccharides | Murine small plaque | NeuAc(a2-3)Gal(b1-3)[NeuAc(a2-6)]GalNAc | Binding | 8574698 |
| Streptococcus pneumoniae | PsaA (Lary family) | unknown carbohydrate ligand | Saccharides | Nasopharynx, Alveolar epithelial cells | Binding | 10341176 | |
| Streptococcus agalactiae | Unknown | Salivary glycoprotein (gp340) | Glycoproteins | Neonatal meningitis | Binding | 11007786 | |
| Escherichia coli | S-fimbriae | unnamed ligand | Oligosaccharides | Neural cell lines | NeuAc(a2-3)Gal(b1-3)GalNAc | Binding | 16564136 |
| Human immunodeficiency virus | HIV surface glycoprotein gp120 | Galactosylceramide (Galactocerebroside) | Monoglycosylceramides | Neural cell lines | Gal(b1-1)Cer | Binding | 1857969 |
| Human immunodeficiency virus | Envelope glycoprotein gp120 | Galactosyl sulfatide | Sulfoglycosphingolipids | Neural receptor | HSO3(-3)Gal(b1-1)Cer | Binding | 1871126 |
| Human immunodeficiency virus | Envelope glycoprotein gp120 | Galactosylceramide (Galactocerebroside) | Monoglycosylceramides | Neural receptor | Gal(b1-1)Cer | Binding | 1871126 |
| Paramyxovirus | Unknown | 116 kDa glycoprotein (containing sialic acid residues with N-linked glycans) | N-glycans | Neurones of all brain regions | Binding | 11666031 | |
| Parvovirus | Unknown | Sialic acid (both O- and N-linked) | Monosaccharides | Nucleated bovine cells | Binding | 15269359 | |
| Moraxella catarrhalis | Fimbriae | Asialo-GM2 (Gangliotriosylceramide; GgO3) | Oligoglycosylceramides | Other than pharyngeal epithelial cells | GalNAc(b1-4)Gal(b1-4)Glc(b1-1)Cer | Binding | 12137200 |
| Norovirus | Unknown | Terminal N-Acetylgalactosamine residue in an alpha linkage | Saccharides | Oyster digestive tissues | Binding | 16707048 | |
| Vibrio cholerae | MSHA (mannose/glucose-specific hemagglutinin) | Mannose | Monosaccharides | Patient with acute watery diarrhea | Man | Binding | 10219594 |
| Vibrio cholerae | MSHA (mannose/glucose-specific hemagglutinin) | Glucose | Monosaccharides | Patient with acute watery diarrhea | Glc | Binding | 10219594 |
| Escherichia coli | PapG (class II) G adhesins | Gal alpha 1-4 Gal-containing isoreceptors | Glycosphingolipids | Patient with septic infection or pyelonephritis | Gal(a1-4)Gal | Binding | |
| Escherichia coli | P-fimbriae | Gal alpha 1-4 Gal-containing isoreceptors | Glycosphingolipids | Patient with septic infection or pyelonephritis | Gal(a1-4)Gal | Binding | |
| Escherichia coli | Type 1-fimbriae | trisaccharide: Man(a1-3)Man(b1-4)GlcNAc | Oligosaccharides | Patient with urinary tract infection | Man(a1-3)Man(b1-4)GlcNAc | Binding | 6138149 |
| Escherichia coli | Type 1-fimbriae | β-D-glycosides | Glycoconjugates | Patient with urinary tract infection | Binding | 6138149 | |
| Escherichia coli | Type 1-fimbriae | Glycoside p-nitrophenyl alpha-D-mannopyranoside | Glycoconjugates | Patient with urinary tract infection | Binding | 6138149 | |
| Escherichia coli | Type 1-fimbriae | Synthetic branched oligosaccharides: Man(a1-3)[Man(a1-6)]Man(a1-6)Man(a1-3)Man | Oligosaccharides | Patient with urinary tract infection | Man(a1-3)[Man(a1-6)]Man(a1-6)[Man(a1-3)]Man | Binding | 6138149 |
| Escherichia coli | Type 1-fimbriae | Synthetic branched oligosaccharides: Man(a1-3)[Man(a1-6)]Man(a1-6)[Man(a1-2)]Man(a1-3)Man | Oligosaccharides | Patient with urinary tract infection | Man(a1-3)[Man(a1-6)]Man(a1-6)[Man(a1-2)Man(a1-3)]Man | Binding | 6138149 |
| Histoplasma capsulatum | Adhesins | Lactosylceramide (Lactocerebroside) | Diosylceramides | Phagocytes | Gal(b1-4)Glc(b1-1)Cer | Binding | 19547878 |
| Burkholderia pseudomallei | Adhesins | Asialo-GM2 (Gangliotriosylceramide; GgO3) | Oligoglycosylceramides | Pharyngeal epithelial cells | GalNAc(b1-4)Gal(b1-4)Glc(b1-1)Cer | Binding | 10497993 |
| Burkholderia pseudomallei | Adhesins | Asialo GM1 (Gangliotetraosylceramide; Gg4; GA1) | Oligoglycosylceramides | Pharyngeal epithelial cells | Gal(b1-3)GalNAc(b1-4)Gal(b1-4)Glc(b1-1)Cer | Binding | 10497993 |
| Rubulavirus | Unknown | N-linked sialylated glycoproteins | Glycoproteins | Pig neurons, glial cells | Binding | 16459111 |
