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Pathogen Adherence to Carbohydrate Database (PACDB)
PACDB provides the information on pathogens (e.g. bacteria, fungus, toxin and virus) adhering to carbohydrates expressed on the cell surface of host animals or plants.
| Source | Last Updated |
|---|---|
| Pathogen Adherence to Carbohydrate Database (PACDB) | June 1, 2016 |
| Species | Pathogen Adherence Molecule | Ligand Name | Ligand Feature | Target Source | Glycan Sequence | Binding | PubMed ID |
|---|---|---|---|---|---|---|---|
| Borrelia burgdorferi | Unknown | Heparan sulfate (fraction: HS-D) | Glycosaminoglycans | Vero cells | Not Binding | 9826395 | |
| Borrelia burgdorferi | Unknown | Dermatan sulfate | Glycosaminoglycans | Vero cells | Not Binding | 9826395 | |
| Foot-and-mouth disease virus | VP1 (RGD peptide) | Heparan sulfate (independent of expression of αvβ3 Integrin on cell-sulface) | Glycosaminoglycans | Extracellular matrix (ECM) | Binding | 9557639 | |
| Borrelia burgdorferi | Unknown | Heparan sulfate (fraction: HS-A) | Glycosaminoglycans | Vero cells | Not Binding | 9826395 | |
| Rabbit fibroma virus | Unknown | Heparan sulfate | Glycosaminoglycans | Mammalian cell surface | Binding | 9445060 | |
| Borrelia burgdorferi | Unknown | Heparan sulfate (fraction: HS-D) | Glycosaminoglycans | Vero cells | Not Binding | 9826395 | |
| Rabbit fibroma virus | Unknown | Heparan sulfate | Glycosaminoglycans | Mammalian cell surface | Binding | 9445060 | |
| Borrelia burgdorferi | Unknown | Heparan sulfate (fraction: HS-A) | Glycosaminoglycans | Vero cells | Not Binding | 9826395 | |
| Borrelia burgdorferi | Unknown | Heparan sulfate (fraction: HS-A) | Glycosaminoglycans | Vero cells | Not Binding | 9826395 | |
| Borrelia burgdorferi | Unknown | Chondroitin 6-sulfate (C-6S) | Glycosaminoglycans | Vero cells | Not Binding | 9826395 | |
| Foot-and-mouth disease virus | VP1 (RGD peptide) | Heparan sulfate (independent of expression of αvβ3 Integrin on cell-sulface) | Glycosaminoglycans | Extracellular matrix (ECM) | Binding | 9557639 | |
| Helicobacter pylori | SabA (sialic acid-binding adhesin) | Sialic acid | Monosaccharides | Human neutrophils | Binding | 15689619 | |
| Streptococcus pneumoniae | CBPs (choline-binding proteins) | Sialic acid | Monosaccharides | Cytokine-activated cells | Binding | 12640357 | |
| Parvovirus | Unknown | Sialic acid (both O- and N-linked) | Monosaccharides | Nucleated bovine cells | Binding | 15269359 | |
| Rabies virus | Unknown | Sialic acid | Monosaccharides | Chicken embryo related cells | Binding | 3583664 | |
| Helicobacter pylori | Adhesins | Five-sugar monosialoganglioside | Monosialoglycosphingolipids | Human leukocytes, Human neutrophils | Binding | 10569742 | |
| Haemophilus influenzae | HMW2 | Oligosaccharides rich in sialic acid | Oligosaccharides | Human epithelial cells | Binding | 12640357 | |
| Haemophilus influenzae | HMW1 | Oligosaccharides rich in sialic acid | Oligosaccharides | Human epithelial cells | Binding | 12640357 | |
| Helicobacter pylori | Adhesins | Gangliosides | Sialoglycosphingolipids | Human leukocytes, Human neutrophils | Binding | 10569742 | |
| Polyoma virus | Capsid VP1 | GD1a-GT1b analog | Sialoglycosphingolipids | (broad range) | Binding | 18809496 | |
| Bordetella pertussis | Pertussis toxin | Gangliosides | Sialoglycosphingolipids | Human alveolar macrophages | Binding | 1729677 | |
| Bordetella pertussis | PT (subunit S3 of B oligomer) | Gangliosides | Sialoglycosphingolipids | Human alveolar macrophages | Binding | 1729677 | |
| Clostridium botulinum | BoNT/B | GT1b (complex with synaptotagmin II) | Trisialoglycosphingolipids | Presynaptic membrane of neuromuscular junction | Binding | 7527117 | |
| Clostridium tetani | Tetanus toxin (Hc fragment) | GT1b analog | Trisialoglycosphingolipids | Synapse | Binding | 18809496 | |
| Clostridium botulinum | Botulinum neurotoxin | GT1b (complex with synaptotagmin II) | Trisialoglycosphingolipids | Presynaptic membrane of neuromuscular junction | Binding | 7527117 |
