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Pathogen Adherence to Carbohydrate Database (PACDB)
PACDB provides the information on pathogens (e.g. bacteria, fungus, toxin and virus) adhering to carbohydrates expressed on the cell surface of host animals or plants.
| Source | Last Updated |
|---|---|
| Pathogen Adherence to Carbohydrate Database (PACDB) | June 1, 2016 |
| Species | Pathogen Adherence Molecule | Ligand Name | Ligand Feature | Target Source | Glycan Sequence | Binding | PubMed ID |
|---|---|---|---|---|---|---|---|
| Burkholderia cepacia | Lectin-like proteins (adhesin) | Gb2 (Galabiosylceramide) | Diosylceramides | Sputa of cystic fibrosis patients | Gal(a1-4)Gal(b1-1)Cer | Binding | 8606110 |
| Bordetella pertussis | CRD (carbohydrate recognition domain) of Fha (Filamentous Hemagglutinin) | Lactosylceramide (Lactocerebroside) | Diosylceramides | Respiratory ciliated cells, Alveolar macrophages | Gal(b1-4)Glc(b1-1)Cer | Binding | 8514379 |
| Escherichia coli | S-fimbriae (SfaA) | Lactosylceramide (Lactocerebroside) | Diosylceramides | Brain endothelial cells | Gal(b1-4)Glc(b1-1)Cer | Binding | 8098039 |
| Escherichia coli | P-fimbriae | Gb2 (Galabiosylceramide) | Diosylceramides | Urine | Gal(a1-4)Gal(b1-1)Cer | Binding | 16564136 |
| Pseudomonas aeruginosa | Type 4-pili | Lactosylceramide (Lactocerebroside) | Diosylceramides | Epithelial cells | Gal(b1-4)Glc(b1-1)Cer | Binding | 9224879 |
| Escherichia coli | P-pili | Gb2 (Galabiosylceramide) | Diosylceramides | Epithelial cells in human urinary tract | Gal(a1-4)Gal(b1-1)Cer | Binding | 9007266 |
| Bordetella pertussis | Pertussis toxin | Lactosylceramide (Lactocerebroside) | Diosylceramides | Human cilia of the respiratory epithelium | Gal(b1-4)Glc(b1-1)Cer | Binding | 1729677 |
| Saccharomyces cerevisiae | Unknown | Lactosylceramide (Lactocerebroside) | Diosylceramides | Human lung, Human polymorphonuclear leukocytes, Human glioma brain cells | Gal(b1-4)Glc(b1-1)Cer | Binding | 2194958 |
| Propionibacterium granulosum | Unknown | Lactosylceramide (Lactocerebroside) | Diosylceramides | Whole dog small intestine | Gal(b1-4)Glc(b1-1)Cer | Binding | 2452754 |
| Helicobacter pylori | 35S-labeled or 125I-labeled proteins | Lactosylceramide (d18:1-16:0/24:1) | Diosylceramides | Human granulocytes, Human erythrocytes | Gal(b1-4)Glc(b1-1)Cer | Not Binding | 9499377 |
| Helicobacter pylori | 35S-labeled or 125I-labeled proteins | Lactosylceramide (d18:1-h16:0/t18:0-h24:0/t18:0-h16:0) | Diosylceramides | Dog small intestine | Gal(b1-4)Glc(b1-1)Cer | Binding | 9499377 |
| Escherichia coli | PapG | alpha-D-galactopyranosyl-(1-4)-beta-D-galactopyranose | Disaccharides | Uroepithelial cells | Gal(a1-4)Gal | Binding | 2886993 |
| Escherichia coli | K1 | unnamed ligand | Disaccharides | Endothelial cells | GlcNAc(b1-4)GlcNAc | Binding | 16564136 |
| Clostridium botulinum | Progenitor toxin (type A) | Lactose | Disaccharides | Intestine-407 cells | Gal(b1-4)Glc | Binding | 15850798 |
| Clostridium botulinum | Progenitor toxin (type A) | N-acetyllactosamine (LacNAc) | Disaccharides | Intestine-407 cells | Gal(b1-4)GlcNAc | Binding | 15850798 |
| Clostridium botulinum | Botulinum neurotoxin (16S) | Lactose | Disaccharides | Intestinal epithelial cells (T84) | Gal(b1-4)Glc | Binding | 17156748 |
| Clostridium botulinum | HA | Lactose | Disaccharides | Intestinal epithelial cells (T84) | Gal(b1-4)Glc | Binding | 17156748 |
| Norovirus | Unknown | Blood group H antigen | Disaccharides | Saliva | Fuc(a1-2)Gal | Binding | 18701592 |
| Escherichia coli | P-fimbriae | Gal alpha 1-4 Gal-containing glicolipids | Glycolipids | Pyelonephritis patients | Gal(a1-4)Gal | Binding | 8574698 |
| Clostridium difficile | Toxin A | α-Gal on Fab of IgA(κ) MAb | Glycoproteins | Mouse | Gal | Binding | 9573079 |
| Clostridium difficile | Toxin A | α-Gal on Fab of IgM(λ) MAb | Glycoproteins | Mouse | Gal | Binding | 9573079 |
| Clostridium difficile | Toxin A | β-Gal on Fab of IgG3(λ) MAb | Glycoproteins | Mouse | Gal | Binding | 9573079 |
| Norovirus | Unknown | Blood group B antigen (B-tri-HSA) | Glycoproteins | Human serum albumin | Gal(a1-3)[Fuc(a1-2)]Gal(b)-O-APE | Binding | 19054801 |
| Norovirus | Unknown | Blood group A antigen (A-tri-HSA) | Glycoproteins | Human serum albumin | GalNAc(a1-3)[Fuc(a1-2)]Gal(b)-O-APE | Binding | 19054801 |
| Norovirus | Unknown | Blood group H1 antigen (HSA) | Glycoproteins | Human serum albumin | Fuc(a1-2)Gal(b1-3)GlcNAc(b1-3)Gal(b1-4)Glc(c)-APD | Binding | 19054801 |
