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Pathogen Adherence to Carbohydrate Database (PACDB)
PACDB provides the information on pathogens (e.g. bacteria, fungus, toxin and virus) adhering to carbohydrates expressed on the cell surface of host animals or plants.
| Source | Last Updated |
|---|---|
| Pathogen Adherence to Carbohydrate Database (PACDB) | June 1, 2016 |
| Species | Pathogen Adherence Molecule | Ligand Name | Ligand Feature | Target Source | Glycan Sequence ▲ | Binding | PubMed ID |
|---|---|---|---|---|---|---|---|
| Clostridium difficile | Toxin A | β-Gal on Fab of IgG3(λ) MAb | Glycoproteins | Mouse | Gal | Binding | 9573079 |
| Actinomyces naeslundii | Type-2 fimbrial lectins (130-kDa glycoprotein) | Galactose | Monosaccharides | Polymorphonuclear leukocytes (PMNs) | Gal | Binding | 7790078 |
| Entamoeba histolytica | Transmembrane heavy subunit (Hgl; 170-kDa) disulfide linked to a GPI-anchored light subunit (Lgl; 31-to 35-kDa). | Galactose | Monosaccharides | Intestinal cells | Gal | Binding | 15322032 |
| Entamoeba histolytica | Gal/GalNAc Lectins (260-kDa) | Galactose | Monosaccharides | c-Met on hepatocytes | Gal | Binding | 9878032 |
| Actinomyces naeslundii | Adhesins | Galactose | Monosaccharides | HL-60 promyelocytic leukemia cell line, Leukosialin (CD43) | Gal | Binding | 11035744 |
| Streptococcus pneumoniae | Adhesins | D-Galactose | Monosaccharides | Vascular endothelial cells (only) | Gal | Binding | 7752878 |
| Clostridium botulinum | Botulinum neurotoxin (16S) | Galactose | Monosaccharides | Intestinal epithelial cells (T84) | Gal | Binding | 17156748 |
| Clostridium botulinum | HA | Galactose | Monosaccharides | Intestinal epithelial cells (T84) | Gal | Binding | 17156748 |
| Rabies virus | Unknown | Galactose | Monosaccharides | Chicken embryo related cells | Gal | Binding | 3583664 |
| Bordetella pertussis | FHA (filamentous hemagglutinin) | Galactose on sulfated glycolipids | Glycolipids | Gal | Binding | 12640357 | |
| Pseudomonas aeruginosa | PA-IL (51-kDa) | D-Galactose | Monosaccharides | Gal | Binding | 15049333 | |
| Pseudomonas aeruginosa | PA-I | Galactose | Monosaccharides | Gal | Binding | 8574698 | |
| Entamoeba histolytica | Membrane-associated lectins (heavy(170-kDa)/light(35-or31-kDa) subunits) | Galactose | Monosaccharides | Gal | Binding | 10225860 | |
| Pseudomonas aeruginosa | PA-IIL | L-Galactose | Monosaccharides | Gal | Binding | 10967261 | |
| Pseudomonas aeruginosa | PA-IL | Galactose | Monosaccharides | Gal | Binding | 10967261 | |
| Clostridium difficile | Unknown | α-Gal on Fab of IgA(κ) MAb | Glycoproteins | Mouse | Gal | Binding | 9573079 |
| Clostridium difficile | Unknown | α-Gal on Fab of IgM(λ) MAb | Glycoproteins | Mouse | Gal | Binding | 9573079 |
| Clostridium difficile | Unknown | β-Gal on Fab of IgG3(λ) MAb | Glycoproteins | Mouse | Gal | Binding | 9573079 |
| Entamoeba histolytica | Raft-like plasma membrane domains | Galactose | Monosaccharides | Intestinal cells | Gal | Binding | 15322032 |
| Escherichia coli | 18-kDa fimbrial adhesin | Galactose derivatives | Saccharides | HEp-2 cells | Gal | Binding | 11368522 |
| Escherichia coli | Unknown | Galactose | Monosaccharides | Gal | Binding | 2885220 | |
| Entamoeba histolytica | 52-kDa recombinant fusion proteins | Galactose | Monosaccharides | Gal | Binding | 8574698 | |
| Enterococcus faecalis | EfaA (Lary family) | D-Galactose-containing residues | Saccharides | Gal | Binding | 12640357 | |
| Bordetella pertussis | Adhesins | terminal Gal(3SO4) β1- residues | Sulfoglycosphingolipids | Human lung, Human trachea | Gal(3SO4)(b | Binding | 1918002 |
| Bordetella parapertussis | Adhesins | terminal Gal(3SO4) β1- residues | Sulfoglycosphingolipids | Gal(3SO4)(b | Binding | 1918002 |
