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Early Phase of HIV Life Cycle

Summary

Organism

Homo sapiens (human)

Reactome

R-HSA-162594

PubChem

R-HSA-162594

Description

In the early phase of HIV lifecycle, an active virion binds and enters a target cell mainly by specific interactions of the viral envelope proteins with host cell surface receptors. The virion core is uncoated to expose a viral nucleoprotein complex containing RNA and viral proteins. HIV RNA genome is reverse transcribed by the viral Reverse Transcriptase to form a cDNA copy, that gets inserted into host cell DNA. The viral Integrase enzyme is vital to carry out the integration of the viral cDNA into the host genome. The host DNA repair enzymes probably repair the breaks in DNA at the sites of integration.

Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.

SPV: a JavaScript Signaling Pathway Visualizer, Bioinformatics, 2018

Displaying **all 3** entries
UniProt ID	Protein Name	Gene Symbol	Pathway Viewer
P18858	DNA ligase 1	LIG1	view
P39748	Flap endonuclease 1	FEN1 RAD2	view
P62937	Peptidyl-prolyl cis-trans isomerase A	CYPA HEL-S-69p PPIA	view

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