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Peptidyl-prolyl cis-trans isomerase A

Summary

UniProt ID

P62937

Gene Symbol

CYPA
PPIA

Gene ID

5478

Organism

Homo sapiens (human)

Annotation

Keyword

3D-structure
Acetylation
Alternative splicing
Apoptosis
Cytoplasm
Direct protein sequencing
Glycoprotein
Host-virus interaction
Isopeptide bond
Nucleus
Phosphoprotein
Reference proteome
Rotamase
Secreted
Ubl conjugation

Gene Ontology (GO)

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GO Term
secretory granule lumen
ficolin-1-rich granule lumen
extracellular region
extracellular space
nucleus
cytoplasm
membrane
vesicle
protein-containing complex
cytosol

Subcellular Location(GO Annotation)

Subcellular in which this glycoprotein is expressed are highlighted in blue.

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GO Term
platelet aggregation
neuron differentiation
negative regulation of stress-activated MAPK cascade
positive regulation of MAPK cascade
positive regulation of viral genome replication
negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
regulation of viral genome replication
protein peptidyl-prolyl isomerization
viral release from host cell
cellular response to oxidative stress

Displaying **all 9** entries
GO Term
unfolded protein binding
RNA binding
peptidyl-prolyl cis-trans isomerase activity
integrin binding
cyclosporin A binding
heparan sulfate binding
virion binding
RNA polymerase II CTD heptapeptide repeat P3 isomerase activity
RNA polymerase II CTD heptapeptide repeat P6 isomerase activity

Annotation information from UniProt.

Sequence

MVNPTVFFDIAVDGEPLGRVSFELFADKVPKTAENFRALSTGEKGFGYKGSCFHRIIPGFMCQGGDFTRHNGTGGKSIYGEKFEDENFILKHTGPGILSMANAGPNTNGSQFFICTAKTEWLDGKHVVFGKVKEGMNIVEAMERFGSRNGKTSKKITIADCGQLE

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 3** entries
Position	Description	GlyTouCan ID	Source
21		G49108TO G70994MS	GlyGen The O-GlcNAc Database
71		G80920RR	GlyGen
108	N-linked (GlcNAc...) asparagine	G49906RN G27915IV G60033FS G62765YT G37995HC	GlycoProtDB UniProt GlyGen

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

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Pathway Name	Organism
APOBEC3G mediated resistance to HIV-1 infection	Homo sapiens
Assembly Of The HIV Virion	Homo sapiens
Basigin interactions	Homo sapiens
Binding and entry of HIV virion	Homo sapiens
Budding and maturation of HIV virion	Homo sapiens
Calcineurin activates NFAT	Homo sapiens
Early Phase of HIV Life Cycle	Homo sapiens
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation	Homo sapiens
Integration of provirus	Homo sapiens
Minus-strand DNA synthesis	Homo sapiens

Disease

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:4947	cholangiocarcinoma	Alliance of Genome Resources
DOID:526	human immunodeficiency virus infectious disease	Alliance of Genome Resources

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

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Guidelines

Summary

External Links

Annotation

International Collaboration

Acknowledgements