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Retrograde neurotrophin signalling

Summary

Organism

Homo sapiens (human)

Reactome

R-HSA-177504

PubChem

R-HSA-177504

Description

Neurotrophin-TRK complexes can be internalized and enter signalling vesicles, which travel retrogradely over long distances from distal nerve terminals to neuronal cell bodies. Such retrograde signalling by neurotrophin-TRK complexes regulates survival, synaptogenesis and maintenance of proper neural connectivity. The neurotrophin-TRK complex may use three distinct internalization pathways. Although Clathrin-mediated endocytosys appears to be the major internalization route, it is controversial whether it also represents the dominant pathway for retrograde transport and signalling. Pyncher-mediated endocytosis might be more relevant in this regard. Moreover, also caveolin-mediated endocytosis may play a role in NGF-TrkA internalization.
Retrograde transport of TRKs is microtubule-dependent: TRKs remain activated and bound to neurotrophins during retrograde transport. The current view is reflected in the signalling endosome model. It is a specialized vesicle containing ligand (NGF, BDNF) bound to its activated TRK receptor, together with activated downstream signalling proteins, transported by motor proteins (dyneins) from nerve terminals to remote cell bodies, where the receptors trigger signalling cascades.

Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.

SPV: a JavaScript Signaling Pathway Visualizer, Bioinformatics, 2018

Displaying **all 10** entries
UniProt ID	Protein Name	Gene Symbol	Pathway Viewer
O94973	AP-2 complex subunit alpha-2	ADTAB AP2A2 CLAPA2 HIP9 HYPJ KIAA0899	view
O95782	AP-2 complex subunit alpha-1	ADTAA AP2A1 CLAPA1	view
P01138	Beta-nerve growth factor	NGF NGFB	view
P04629	High affinity nerve growth factor receptor	MTC NTRK1 TRK TRKA	view
P09496	Clathrin light chain A	CLTA	view
P50570	Dynamin-2	DNM2 DYN2	view
P63010	AP-2 complex subunit beta	ADTB2 AP2B1 CLAPB1	view
Q00610	Clathrin heavy chain 1	CLH17 CLTC CLTCL2 KIAA0034	view
Q05193	Dynamin-1	DNM DNM1	view
Q96CW1	AP-2 complex subunit mu	AP2M1 CLAPM1 KIAA0109	view

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