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Heme degradation

Summary

Organism

Homo sapiens (human)

Reactome

R-HSA-189483

PubChem

R-HSA-189483

Description

Most of the heme degraded in humans comes from hemoglobin. Approximately 6-8 grams of hemoglobin is degraded daily which is equivalent to approximately 300 milligrams of heme per day. Heme is not recycled so it must be degraded and excreted. The iron, however, is conserved. There are two steps to heme degradation;
1. cleavage of the heme ring by a microsomal heme oxygenase producing biliverdin
2. biliverdin is reduced to bilirubin.
Bilirubin can then be conjugated with glucuronic acid and excreted.

Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.

SPV: a JavaScript Signaling Pathway Visualizer, Bioinformatics, 2018

Displaying **all 9** entries
UniProt ID	Protein Name	Gene Symbol	Pathway Viewer
P02768	Albumin	ALB GIG20 GIG42 PRO0903 PRO1708 PRO2044 PRO2619 PRO2675 UNQ696/PRO1341	view
P22309	UDP-glucuronosyltransferase 1A1	GNT1 UGT1 UGT1A1	view
P22310	UDP-glucuronosyltransferase 1A4	GNT1 UGT1 UGT1A4	view
P30519	Heme oxygenase 2	HMOX2 HO2	view
P33527	Multidrug resistance-associated protein 1	ABCC1 MRP MRP1	view
Q92887	ATP-binding cassette sub-family C member 2	ABCC2 CMOAT CMOAT1 CMRP MRP2	view
Q9NPD5	Solute carrier organic anion transporter family member 1B3	LST2 OATP1B3 OATP8 SLC21A8 SLCO1B3	view
Q9UNQ0	Broad substrate specificity ATP-binding cassette transporter ABCG2	ABCG2 ABCP BCRP BCRP1 MXR	view
Q9Y6L6	Solute carrier organic anion transporter family member 1B1	LST1 OATP1B1 OATP2 OATPC SLC21A6 SLCO1B1	view

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