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UDP-glucuronosyltransferase 1A4

Summary

UniProt ID: P22310
Gene Symbol: UGT1A4 GNT1 UGT1
Gene ID: 54657
Organism: Homo sapiens (human)

External Links

GlyConnect

UDP-glucuronosyltransferase 1-4

GlyGen

P22310

PubChem

P22310

SwissLipids

SLP:000001872

The Human Metabolome Database

HMDBP00478

Re-Glyco

P22310

Annotation

Keyword: Alternative splicing Endoplasmic reticulum Glycoprotein Glycosyltransferase Lipid metabolism Proteomics identification Reference proteome Signal Transmembrane helix

Gene Ontology (GO)

Displaying **all 5** entries
GO Term	Evidence Code	Reference
bilirubin conjugation	TAS	Reactome
glucuronate metabolic process	TAS	Reactome
heme catabolic process	TAS	Reactome
negative regulation of fatty acid metabolic process	ISS	PMID
vitamin D3 metabolic process	IDA	PMID PMID

GO Hierarchy

biological process

cellular process [inference]

metabolic process [inference]

catabolic process [inference]

tetrapyrrole catabolic process [inference]

porphyrin-containing compound catabolic process [inference]

tetrapyrrole metabolic process [inference]

porphyrin-containing compound metabolic process [inference]

porphyrin-containing compound catabolic process [inference]

heme metabolic process [inference]

heme catabolic process

tetrapyrrole catabolic process [inference]

porphyrin-containing compound catabolic process [inference]

pigment metabolic process [inference]

heme metabolic process [inference]

heme catabolic process

pigment catabolic process [inference]

heme catabolic process

primary metabolic process [inference]

lipid metabolic process [inference]

steroid metabolic process [inference]

vitamin D metabolic process [inference]

vitamin D3 metabolic process

small molecule metabolic process [inference]

alcohol metabolic process [inference]

secondary alcohol metabolic process [inference]

vitamin D3 metabolic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

glucuronate metabolic process

biological regulation [inference]

regulation of biological process [inference]

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of metabolic process [inference]

negative regulation of lipid metabolic process [inference]

negative regulation of fatty acid metabolic process

negative regulation of small molecule metabolic process [inference]

negative regulation of fatty acid metabolic process

regulation of cellular process [inference]

regulation of metabolic process [inference]

negative regulation of metabolic process [inference]

negative regulation of lipid metabolic process [inference]

negative regulation of fatty acid metabolic process

negative regulation of small molecule metabolic process [inference]

negative regulation of fatty acid metabolic process

regulation of ketone metabolic process [inference]

regulation of fatty acid metabolic process [inference]

negative regulation of fatty acid metabolic process

regulation of small molecule metabolic process [inference]

regulation of fatty acid metabolic process [inference]

negative regulation of fatty acid metabolic process

negative regulation of small molecule metabolic process [inference]

negative regulation of fatty acid metabolic process

regulation of primary metabolic process [inference]

regulation of lipid metabolic process [inference]

regulation of fatty acid metabolic process [inference]

negative regulation of fatty acid metabolic process

negative regulation of lipid metabolic process [inference]

negative regulation of fatty acid metabolic process

negative regulation of cellular process [inference]

negative regulation of metabolic process [inference]

negative regulation of lipid metabolic process [inference]

negative regulation of fatty acid metabolic process

negative regulation of small molecule metabolic process [inference]

negative regulation of fatty acid metabolic process

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	Reference
endoplasmic reticulum	NAS	PMID
endoplasmic reticulum	IDA	PMID
endoplasmic reticulum	IBA	GO_REF
endoplasmic reticulum	IEA	GO_REF
endoplasmic reticulum membrane	NAS	PMID

GO Hierarchy

cellular component

cellular anatomical structure [inference]

membrane [inference]

organelle membrane [inference]

endoplasmic reticulum membrane

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

Displaying entries **1 - 5** of 15 in total

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GO Term	Evidence Code	Reference
enzyme inhibitor activity	ISS	PMID
enzyme inhibitor activity	IBA	GO_REF
glucuronosyltransferase activity	ISS	PMID
glucuronosyltransferase activity	TAS	Reactome Reactome Reactome Reactome Reactome
glucuronosyltransferase activity	IDA	PMID PMID PMID PMID PMID PMID PMID PMID

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

glycosyltransferase activity [inference]

UDP-glycosyltransferase activity [inference]

glucuronosyltransferase activity

hexosyltransferase activity [inference]

glucuronosyltransferase activity

binding [inference]

protein binding [inference]

enzyme binding

identical protein binding [inference]

protein homodimerization activity

protein dimerization activity [inference]

molecular function regulator activity [inference]

enzyme regulator activity [inference]

enzyme inhibitor activity

molecular function inhibitor activity [inference]

enzyme inhibitor activity

Gene Ontology information from UniProt.

Annotation information from UniProt.

Sequence

MARGLQVPLPRLATGLLLLLSVQPWAESGKVLVVPTDGSPWLSMREALRELHARGHQAVVLTPEVNMHIKEEKFFTLTAYAVPWTQKEFDRVTLGYTQGFFETEHLLKRYSRSMAIMNNVSLALHRCCVELLHNEALIRHLNATSFDVVLTDPVNLCGAVLAKYLSIPAVFFWRYIPCDLDFKGTQCPNPSSYIPKLLTTNSDHMTFLQRVKNMLYPLALSYICHTFSAPYASLASELFQREVSVVDLVSYASVWLFRGDFVMDYPRPIMPNMVFIGGINCANGKPLSQEFEAYINASGEHGIVVFSLGSMVSEIPEKKAMAIADALGKIPQTVLWRYTGTRPSNLANNTILVKWLPQNDLLGHPMTRAFITHAGSHGVYESICNGVPMVMMPLFGDQMDNAKRMETKGAGVTLNVLEMTSEDLENALKAVINDKSYKENIMRLSSLHKDRPVEPLDLAVFWVEFVMRHKGAPHLRPAAHDLTWYQYHSLDVIGFLLAVVLTVAFITFKCCAYGYRKCLGKKGRVKKAHKSKTH

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 4** entries
Position	Description	PubMed ID	GlyTouCan ID	Source
119	N-linked (GlcNAc...) asparagine			UniProt GlyGen
142	N-linked (GlcNAc...) asparagine	19159218		UniProt GlyGen
296	N-linked (GlcNAc...) asparagine			UniProt GlyGen
348	N-linked (GlcNAc...) asparagine	19159218 29741879	G39188ZX G14669DU	UniProt GlyGen GlyConnect