Regulation of actin dynamics for phagocytic cup formation

Summary
Species
Homo sapiens
Reactome
PubChem
Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.
PAK1 dimerPAK1Active RAC1/CDC42RAC1:GTP,CDC42:GTP:PAK1LIMK1p-T508-LIMK1ADPATPVAV1,2,3clustered IgG-Ag:p-FCGRs:p-6Y-SYK:VAVclustered IgG-Ag:p-FCGRs:p-6Y-SYKPIP3clustered IgG-Ag:p-FCGRs:p-6Y-SYK:p-VAVGTPGDPRAC1:GTPRAC1:GDPCRK:DOCK180:ELMO1,ELMO2CRKII:DOCK180:ELMO complex recruited to phagocytic cupp-S144,T423-PAK1pLIMK dimer:HSP-90HSP90AA1,HSP90AB1Active LIMK1pCofilin: Active LIMK-1CFL1clustered IgG-Ag:p-FCGRsMyosinMyosin-Actin filamentsclustered IgG-Ag:p-FCGRsPiMother filament:branching complex:daughter filamentWRC:IRSp53/58:RAC1:GTP:PIP3BAIAP2WRCp-Y-WRC:IRSp53/58:RAC1:GTP:PIP3p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3CDC42:GDPCDC42:GTPPIP2CDC42:GTP:WASP/N-WASPWASP/N-WASPCDC42:GTP:WASP/N-WASP:WIP:SH3 proteinsSH3 domain proteinsWIP family proteinsCDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteinsARP2/3 complex (ATP bound)WAVE2, WASP, N-WASP:ARP2/3 complex:G-actinWAVE2, WASP, N-WASPG-actinMother filament:branching complexF-actinMother filament:ARP2/3:actin:ADPMyosin-X dimerActin filament bound Myosin-XPI(3,4)P2
ProteinProtein familyDNARNAComplexChemical/MoleculePhenotype/StimulusNucleusMitochondriaEndosomeGolgi apparatusLysosomeMembraneUp-regulatesDown-regulatesPhysical interactionUnknownDirectIndirectBindingHighlight
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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01


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Last updated: April 7, 2025