Regulation of actin dynamics for phagocytic cup formation

Summary
Species
Homo sapiens
Reactome
PubChem
Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.
RAC1:GTPWRC:IRSp53/58:RAC1:GTP:PIP3PIP3BAIAP2WRCATPADPp-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3GTPGDPCDC42:GTPCDC42:GDPWASP/N-WASPCDC42:GTP:WASP/N-WASPPIP2CDC42:GTP:WASP/N-WASP:WIP:SH3 proteinsSH3 domain proteinsWIP family proteinsCDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteinsWAVE2, WASP, N-WASPWAVE2, WASP, N-WASP:ARP2/3 complex:G-actinG-actinARP2/3 complex (ATP bound)Mother filament:branching complexF-actinMother filament:ARP2/3:actin:ADPMother filament:branching complex:daughter filamentActin filament bound Myosin-XPI(3,4)P2PiMyosin-X dimerActive RAC1/CDC42PAK1RAC1:GTP,CDC42:GTP:PAK1PAK1 dimerLIMK1p-T508-LIMK1clustered IgG-Ag:p-FCGRs:p-6Y-SYKclustered IgG-Ag:p-FCGRs:p-6Y-SYK:VAVVAV1,2,3clustered IgG-Ag:p-FCGRs:p-6Y-SYK:p-VAVRAC1:GDPCRKII:DOCK180:ELMO complex recruited to phagocytic cupCRK:DOCK180:ELMO1,ELMO2p-S144,T423-PAK1pLIMK dimer:HSP-90HSP90AA1,HSP90AB1Active LIMK1CFL1pCofilin: Active LIMK-1Myosin-Actin filamentsMyosinclustered IgG-Ag:p-FCGRsclustered IgG-Ag:p-FCGRs
ProteinProtein familyDNARNAComplexChemical/MoleculePhenotype/StimulusNucleusMitochondriaEndosomeGolgi apparatusLysosomeMembraneUp-regulatesDown-regulatesPhysical interactionUnknownDirectIndirectBindingHighlight
a simple tooltip

About Release Notes Help Feedback

International Collaboration

GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01


Logo License Policies Site Map

Contact: support@glycosmos.org

This work is licensed under Creative Commons Attribution 4.0 International


GlyCosmos Portal v4.1.1

Last updated: February 17, 2025