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Tyrosine-protein kinase ABL1
Summary
- UniProt ID
- P00519
- Gene Symbol
-
- ABL
- ABL1
- JTK7
- Gene ID
- 25
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- 3D-structure
- ATP-binding
- Acetylation
- Alternative splicing
- Apoptosis
- Autophagy
- Cell adhesion
- Chromosomal rearrangement
- Cytoskeleton
- DNA repair
- DNA-binding
- Disease variant
- Endocytosis
- Magnesium
- Manganese
- Membrane
- Metal-binding
- Mitochondrion
- Myristate
- Nucleus
- Phosphoprotein
- Proto-oncogene
- Reference proteome
- SH2 domain
- SH3 domain
- Tyrosine-protein kinase
- Ubl conjugation
- Gene Ontology (GO)
| GO Term |
|---|
| nucleus |
| nucleolus |
| cytoplasm |
| mitochondrion |
| plasma membrane |
| actin cytoskeleton |
| dendrite |
| nuclear membrane |
| protein-containing complex |
| neuronal cell body |
| GO Term |
|---|
| magnesium ion binding |
| DNA binding |
| actin monomer binding |
| protein kinase activity |
| protein tyrosine kinase activity |
| non-membrane spanning protein tyrosine kinase activity |
| protein kinase C binding |
| ATP binding |
| SH3 domain binding |
| syntaxin binding |
Sequence
MLEICLKLVGCKSKKGLSSSSSCYLEEALQRPVASDFEPQGLSEAARWNSKENLLAGPSENDPNLFVALYDFVASGDNTLSITKGEKLRVLGYNHNGEWCEAQTKNGQGWVPSNYITPVNSLEKHSWYHGPVSRNAAEYLLSSGINGSFLVRESESSPGQRSISLRYEGRVYHYRINTASDGKLYVSSESRFNTLAELVHHHSTVADGLITTLHYPAPKRNKPTVYGVSPNYDKWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCPEKVYELMRACWQWNPSDRPSFAEIHQAFETMFQESSISDEVEKELGKQGVRGAVSTLLQAPELPTKTRTSRRAAEHRDTTDVPEMPHSKGQGESDPLDHEPAVSPLLPRKERGPPEGGLNEDERLLPKDKKTNLFSALIKKKKKTAPTPPKRSSSFREMDGQPERRGAGEEEGRDISNGALAFTPLDTADPAKSPKPSNGAGVPNGALRESGGSGFRSPHLWKKSSTLTSSRLATGEEEGGGSSSKRFLRSCSASCVPHGAKDTEWRSVTLPRDLQSTGRQFDSSTFGGHKSEKPALPRKRAGENRSDQVTRGTVTPPPRLVKKNEEAADEVFKDIMESSPGSSPPNLTPKPLRRQVTVAPASGLPHKEEAGKGSALGTPAAAEPVTPTSKAGSGAPGGTSKGPAEESRVRRHKHSSESPGRDKGKLSRLKPAPPPPPAASAGKAGGKPSQSPSQEAAGEAVLGAKTKATSLVDAVNSDAAKPSQPGEGLKKPVLPATPKPQSAKPSGTPISPAPVPSTLPSASSALAGDQPSSTAFIPLISTRVSLRKTRQPPERIASGAITKGVVLDSTEALCLAISRNSEQMASHSAVLEAGKNLYTFCVSYVDSIQQMRNKFAFREAINKLENNLRELQICPATAGSGPAATQDFSKLLSSVKEISDIVQR
Glycosylation Sites
| Position | Description | PubMed ID | GlyTouCan ID | Source |
|---|---|---|---|---|
| 613 |
|
|
||
| 823 |
|
|
||
| 840 |
|
|||
| 855 |
|
G49108TO
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Pathway
| Pathway Name | Organism |
|---|---|
| Cyclin D associated events in G1 | Homo sapiens |
| FCGR3A-mediated phagocytosis | Homo sapiens |
| Factors involved in megakaryocyte development and platelet production | Homo sapiens |
| HDR through Single Strand Annealing (SSA) | Homo sapiens |
| MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis | Homo sapiens |
| Myogenesis | Homo sapiens |
| RHO GTPases Activate WASPs and WAVEs | Homo sapiens |
| RUNX1 regulates transcription of genes involved in differentiation of HSCs | Homo sapiens |
| RUNX2 regulates osteoblast differentiation | Homo sapiens |
| Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks | Homo sapiens |
Human Protein Atlas
Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.
Disease
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0050866 | oral squamous cell carcinoma | |
| DOID:0080630 | B-lymphoblastic leukemia/lymphoma | |
| DOID:4914 | esophagus adenocarcinoma | |
| DOID:8552 | chronic myeloid leukemia | |
| DOID:9119 | acute myeloid leukemia | |
| DOID:9256 | colorectal cancer |
