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FCERI mediated MAPK activation

Summary

Organism

Homo sapiens (human)

Reactome

R-HSA-2871796

PubChem

R-HSA-2871796

Description

Formation of the LAT signaling complex leads to activation of MAPK and production of cytokines. The sequence of events that leads from LAT to cytokine production has not been as clearly defined as the sequence that leads to degranulation. However, the pathways that lead to cytokine production require the guanine-nucleotide-exchange factors SOS and VAV that regulate GDP-GTP exchange of RAS. After its activation, RAS positively regulates the RAF-dependent pathway that leads to phosphorylation and, in part, activation of the mitogen-activated protein kinases (MAPKs) extracellular-signal-regulated kinase 1 (ERK1) and ERK2 (Gilfillan & Tkaczyk 2006).

Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.

SPV: a JavaScript Signaling Pathway Visualizer, Bioinformatics, 2018

Displaying entries **1 - 10** of 26 in total

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UniProt ID	Protein Name	Gene Symbol	Pathway Viewer
P01100	Protein c-Fos	FOS G0S7	view
P01111	GTPase NRas	HRAS1 NRAS	view
P01112	GTPase HRas	HRAS HRAS1	view
P01593	Immunoglobulin kappa variable 1D-33	IGKV1D-33	view
P01705	Immunoglobulin lambda variable 2-23	IGLV2-23	view
P01824	Immunoglobulin heavy variable 4-39	IGHV4-39	view
P01834	Immunoglobulin kappa constant	IGKC	view
P01854	Immunoglobulin heavy constant epsilon	IGHE	view
P04433	Immunoglobulin kappa variable 3-11	IGKV3-11	view
P05412	Transcription factor Jun	JUN	view

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