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SUMOylation of transcription factors

Summary

Organism

Homo sapiens (human)

Reactome

R-HSA-3232118

PubChem

R-HSA-3232118

Description

Proteins classified as transcription factors constitute a disproportionate number of SUMOylation targets. In most cases SUMOylation inhibits transcriptional activation, however in some cases such as TP53 (p53) SUMOylation can enhance activation. Inhibition of transcription by SUMOylation may be due to interference with DNA binding, re-localization to inactive nuclear bodies, or recruitment of repressive cofactors such as histone deacetylases (reviewed in Girdwood et al. 2004, Gill 2005).

Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.

SPV: a JavaScript Signaling Pathway Visualizer, Bioinformatics, 2018

Displaying **all 9** entries
UniProt ID	Protein Name	Gene Symbol	Pathway Viewer
O75030	Microphthalmia-associated transcription factor	BHLHE32 MITF	view
O75925	E3 SUMO-protein ligase PIAS1	DDXBP1 PIAS1	view
P04637	Cellular tumor antigen p53	P53 TP53	view
P58012	Forkhead box protein L2	FOXL2	view
P63165	Small ubiquitin-related modifier 1	OK/SW-cl.43 SMT3C SMT3H3 SUMO1 UBL1	view
Q00987	E3 ubiquitin-protein ligase Mdm2	MDM2	view
Q02447	Transcription factor Sp3	SP3	view
Q12888	TP53-binding protein 1	TP53BP1	view
Q13330	Metastasis-associated protein MTA1	MTA1	view

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