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NCAM signaling for neurite out-growth

Summary

Organism

Homo sapiens (human)

Reactome

R-HSA-375165

PubChem

R-HSA-375165

Description

The neural cell adhesion molecule, NCAM, is a member of the immunoglobulin (Ig) superfamily and is involved in a variety of cellular processes of importance for the formation and maintenance of the nervous system. The role of NCAM in neural differentiation and synaptic plasticity is presumed to depend on the modulation of intracellular signal transduction cascades. NCAM based signaling complexes can initiate downstream intracellular signals by at least two mechanisms: (1) activation of FGFR and (2) formation of intracellular signaling complexes by direct interaction with cytoplasmic interaction partners such as Fyn and FAK. Tyrosine kinases Fyn and FAK interact with NCAM and undergo phosphorylation and this transiently activates the MAPK, ERK 1 and 2, cAMP response element binding protein (CREB) and transcription factors ELK and NFkB. CREB activates transcription of genes which are important for axonal growth, survival, and synaptic plasticity in neurons.

NCAM1 mediated intracellular signal transduction is represented in the figure below. The Ig domains in NCAM1 are represented in orange ovals and Fn domains in green squares. The tyrosine residues susceptible to phosphorylation are represented in red circles and their positions are numbered. Phosphorylation is represented by red arrows and dephosphorylation by yellow. Ig, Immunoglobulin domain; Fn, Fibronectin domain; Fyn, Proto-oncogene tyrosine-protein kinase Fyn; FAK, focal adhesion kinase; RPTPalpha, Receptor-type tyrosine-protein phosphatase; Grb2, Growth factor receptor-bound protein 2; SOS, Son of sevenless homolog; Raf, RAF proto-oncogene serine/threonine-protein kinase; MEK, MAPK and ERK kinase; ERK, Extracellular signal-regulated kinase; MSK1, Mitogen and stress activated protein kinase 1; CREB, Cyclic AMP-responsive element-binding protein; CRE, cAMP response elements.

Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.

SPV: a JavaScript Signaling Pathway Visualizer, Bioinformatics, 2018

Displaying entries **1 - 10** of 14 in total

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UniProt ID	Protein Name	Gene Symbol	Pathway Viewer
O15020	Spectrin beta chain, non-erythrocytic 2	KIAA0302 SCA5 SPTBN2	view
O75582	Ribosomal protein S6 kinase alpha-5	MSK1 RPS6KA5	view
P01111	GTPase NRas	HRAS1 NRAS	view
P01112	GTPase HRas	HRAS HRAS1	view
P02549	Spectrin alpha chain, erythrocytic 1	SPTA SPTA1	view
P11277	Spectrin beta chain, erythrocytic	SPTB SPTB1	view
P13591	Neural cell adhesion molecule 1	NCAM NCAM1	view
P18433	Receptor-type tyrosine-protein phosphatase alpha	PTPA PTPRA PTPRL2	view
Q01082	Spectrin beta chain, non-erythrocytic 1	SPTB2 SPTBN1	view
Q05397	Focal adhesion kinase 1	FAK FAK1 PTK2	view

Displaying 1 entry
GlyCosmos Lectin	UniProt ID	Lectin Name	Pathway Viewer
GL_002347	P13591	Neural cell adhesion molecule 1	view

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