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Ephrin signaling

Summary

Organism

Homo sapiens (human)

Reactome

R-HSA-3928664

PubChem

R-HSA-3928664

Description

The interaction between ephrin (EFN) ligands and EPH receptors results not only in forward signaling through the EPH receptor, but also in 'reverse' signaling through the EFN ligand itself. Reverse signaling through EFNB is required for correct spine morphogenesis and proper path-finding of corpus callosum and dorsal retinal axons. The molecular mechanism by which EFNBs transduce a reverse signal involves phosphorylation of multiple, conserved tyrosines on the intracellular domain of B-type ephrins, facilitating binding of the SH2/SH3 domain adaptor protein GRB4 and subsequent cytoskeletal remodeling (Bruckner et al. 1997, Cowan & Henkemeyer 2001, Lu et al. 2001). The other mechanism of reverse signaling involves the C-terminus PSD-95/Dlg/ZO-1 (PDZ)-binding motif of EFNBs which recruits various PDZ domain containing proteins. Phosphorylation and PDZ-dependent reverse signaling by ephrin-B1 have each been proposed to play important roles in multiple contexts in development and disease (Bush & Soriano 2009).

Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.

SPV: a JavaScript Signaling Pathway Visualizer, Bioinformatics, 2018

Displaying entries **1 - 10** of 15 in total

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UniProt ID	Protein Name	Gene Symbol	Pathway Viewer
O15197	Ephrin type-B receptor 6	EPHB6	view
O75914	Serine/threonine-protein kinase PAK 3	OPHN3 PAK3	view
P19105	Myosin regulatory light chain 12A	MLCB MRLC3 MYL12A RLC	view
P29323	Ephrin type-B receptor 2	DRT EPHB2 EPHT3 EPTH3 ERK HEK5 TYRO5	view
P52799	Ephrin-B2	EFNB2 EPLG5 HTKL LERK5	view
P54753	Ephrin type-B receptor 3	EPHB3 ETK2 HEK2 TYRO6	view
P54760	Ephrin type-B receptor 4	EPHB4 HTK MYK1 TYRO11 hCG_20448 tcag7.1248	view
P54762	Ephrin type-B receptor 1	ELK EPHB1 EPHT2 HEK6 NET	view
P63000	Ras-related C3 botulinum toxin substrate 1	MIG5 RAC1 TC25	view
P98172	Ephrin-B1	EFL3 EFNB1 EPLG2 LERK2	view

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