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Role of ABL in ROBO-SLIT signaling

Summary

Organism

Homo sapiens (human)

Reactome

R-HSA-428890

PubChem

R-HSA-428890

Description

ABL (ABL1 or ABL2) plays a dual role in the ROBO pathway. As a key enzymatic component in the signaling pathway, ABL supports repellent signaling (by recruiting the necessary actin binding proteins) and also feeds back on the receptor (by down regulating through phosphorylation) to adjust the sensitivity of the pathway.
ABL cooperates with multiple effectors, including the actin binding protein Capulet (Capt) and Orbit/MAST/CLASP, suggesting that ABL simultaneously coordinates the dynamics of two major cytoskeletal systems to achieve growth cone repellent guidance.

Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.

SPV: a JavaScript Signaling Pathway Visualizer, Bioinformatics, 2018

Displaying **all 8** entries
UniProt ID	Protein Name	Gene Symbol	Pathway Viewer
O75122	CLIP-associating protein 2	CLASP2 KIAA0627	view
O94813	Slit homolog 2 protein	SLIL3 SLIT2	view
P00519	Tyrosine-protein kinase ABL1	ABL ABL1 JTK7	view
P40123	Adenylyl cyclase-associated protein 2	CAP2	view
P42684	Tyrosine-protein kinase ABL2	ABL2 ABLL ARG	view
Q01518	Adenylyl cyclase-associated protein 1	CAP CAP1	view
Q7Z460	CLIP-associating protein 1	CLASP1 KIAA0622 MAST1	view
Q9Y6N7	Roundabout homolog 1	DUTT1 ROBO1	view

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