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GLI proteins bind promoters of Hh responsive genes to promote transcription

Summary

Organism

Homo sapiens (human)

Reactome

R-HSA-5635851

PubChem

R-HSA-5635851

Description

GLI proteins are bifunctional DNA-binding proteins that recognize consensus GLI sites 5'-GACCACCC-3' in the promoters of target genes (Kinzler and Vogelstein, 1990). Pathway induction upon ligand-binding diverts the GLI proteins from the processing/degradation pathway that generates the truncated repressor form and promotes the formation of the full-length transcriptional activator (reviewed in Hui and Angers, 2011; Briscoe and Therond, 2013). GLI-dependent target genes have been identified by a number of ChIP based screens, and well-established, direct targets include a number of Hh pathway members including PTCH1, PTCH2, GLI1, HHIP and BOC (Lee et al, 2010; Vokes et al, 2007; Vokes et al, 2008; Agren et al, 2004; Bai et al, 2004; Bai et al, 2002; Dai et al, 1999). Full-length GLI proteins nucleate the assembly of a transcriptional activation complex at target gene promoters, but the details of interacting partners are not well known. The C-terminus of GLI3 has been shown to interact with a number of transcriptional activators including the histone acetyltransferase CBP, the Mediator component Med12 and the TATA-box recognition protein TAF31, but the detail of how and when these binding partners interact is not known (Dai et al, 1999; Zhou et al, 2006; Yoon et al, 1998; reviewed in Hui and Angers, 2011). Each of the GLI proteins has been shown to bind to CDC 73, a component of the PAF complex that has roles in RNA polymerase II-mediated transcription (Mosimann et al, 2009; reviewed in Tomson and Arndt, 2013).

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SPV: a JavaScript Signaling Pathway Visualizer, Bioinformatics, 2018

Displaying **all 3** entries
UniProt ID	Protein Name	Gene Symbol	Pathway Viewer
P08151	Zinc finger protein GLI1	GLI GLI1	view
P10070	Zinc finger protein GLI2	GLI2 THP	view
P10071	Transcriptional activator GLI3	GLI3	view

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