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MIRAGE
Processing of DNA double-strand break ends

Summary
Species
Homo sapiens
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PubChem
Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.
UBC9_HUMANDNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:SUMO2:K1840,p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:p-5S,2T-BRCA1-A complexDNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:p-5S,2T-BRCA1-A complexUBE2IUIMC1UbRNF8:Zn2+p-S102-WHSC1PIAS4p-5S-BRCA1:p-2T-BARD1p-T4827,SUMO1-HERC2BRCC3UBC13:MMS2NBA1K48PolyUb:SUMO2:K1840,p-5T-MDC1 dimerp-S406-ABRA1K63PolyUb:K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-NucleosomeBREDNA DSB:p-MRN:p-S1981,Ac-K3016-ATM:KAT5RNF168p-S25,S1778-TP53BP1NADRBBP8 homotetramerAc-K-RBBP8 homotetramerNAM2'-O-acetyl-ADP-riboseCCNA:p-T160-CDK2DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:CCNA:p-T160-CDK2:RBBP8ATPADPDNA DSBs:p-MRN:p-S327,T847-RBBP8:p-S1981,Ac-K3016-ATM:KAT5DNA DSBs:p-MRN:p-S327,T847,T859-RBBP8:p-S1981,Ac-K3016-ATM:KAT5DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-BRCA1-C complexH2O3' short overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complexdNTPEXO1,DNA2:BLM,WRN3' short overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1p-S990,Ac-K1249-BRIP13' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1RPA heterotrimerATR:ATRIP:RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1ATR:ATRIPRAD17:RFCATR:ATRIP:RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1TOPBP19-1-1 complexRHNO1ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1:TIMELESS:TIPIN:p-T916,S945-CLSPN:CHEK1Chk1p-T916,S945-CLSPNTIMELESS:TIPINphospho-Chk1p-RPA heterotrimerPi
ProteinProtein familyDNARNAComplexChemical/MoleculePhenotype/StimulusNucleusMitochondriaEndosomeGolgi apparatusLysosomeMembraneUp-regulatesDown-regulatesPhysical interactionUnknownDirectIndirectBindingHighlight
SPV: a JavaScript Signaling Pathway Visualizer, Bioinformatics, 2018
Displaying entries 1 - 10 of 47 in total
UniProt ID Protein Name Gene Symbol Pathway Viewer
O14757 Serine/threonine-protein kinase Chk1
  • CHEK1
  • CHK1
 view
O60814 Histone H2B type 1-K
  • H2BC12
  • H2BFT
  • HIRIP1
  • HIST1H2BK
 view
O60934 Nibrin
  • NBN
  • NBS
  • NBS1
  • P95
 view
O75943 Cell cycle checkpoint protein RAD17
  • R24L
  • RAD17
 view
O95714 E3 ubiquitin-protein ligase HERC2
  • HERC2
 view
O96028 Histone-lysine N-methyltransferase NSD2
  • KIAA1090
  • MMSET
  • NSD2
  • TRX5
  • WHSC1
 view
P06899 Histone H2B type 1-J
  • H2BC11
  • H2BFR
  • HIST1H2BJ
 view
P15927 Replication protein A 32 kDa subunit
  • REPA2
  • RPA2
  • RPA32
  • RPA34
 view
P16104 Histone H2AX
  • H2AFX
  • H2AX
 view
P23527 Histone H2B type 1-O
  • H2BC17
  • H2BFH
  • H2BFN
  • HIST1H2BO
 view
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GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: April 7, 2025