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Serine/threonine-protein kinase Chk1
Summary
- UniProt ID
- O14757
- Gene Symbol
-
- CHEK1
- CHK1
- Gene ID
- 1111
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- 3D-structure
- ATP-binding
- Alternative splicing
- Cell cycle
- Chromosome
- Cytoskeleton
- DNA repair
- Disease variant
- Isopeptide bond
- Nucleus
- Phosphoprotein
- Reference proteome
- Serine/threonine-protein kinase
- Ubl conjugation
- Gene Ontology (GO)
| GO Term |
|---|
| chromatin |
| extracellular space |
| nucleus |
| cytoplasm |
| protein-containing complex |
| intracellular membrane-bounded organelle |
| nucleoplasm |
| cytosol |
| replication fork |
| centrosome |
Sequence
MAVPFVEDWDLVQTLGEGAYGEVQLAVNRVTEEAVAVKIVDMKRAVDCPENIKKEICINKMLNHENVVKFYGHRREGNIQYLFLEYCSGGELFDRIEPDIGMPEPDAQRFFHQLMAGVVYLHGIGITHRDIKPENLLLDERDNLKISDFGLATVFRYNNRERLLNKMCGTLPYVAPELLKRREFHAEPVDVWSCGIVLTAMLAGELPWDQPSDSCQEYSDWKEKKTYLNPWKKIDSAPLALLHKILVENPSARITIPDIKKDRWYNKPLKKGAKRPRVTSGGVSESPSGFSKHIQSNLDFSPVNSASSEENVKYSSSQPEPRTGLSLWDTSPSYIDKLVQGISFSQPTCPDHMLLNSQLLGTPGSSQNPWQRLVKRMTRFFTKLDADKSYQCLKETCEKLGYQWKKSCMNQVTISTTDRRNNKLIFKVNLLEMDDKILVDFRLSKGDGLEFKRHFLKIKGKLIDIVSSQKIWLPAT
Glycosylation Sites
| Position | Description | PubMed ID | GlyTouCan ID | Source |
|---|---|---|---|---|
| 417 |
|
G49108TO
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Pathway
| Pathway Name | Organism |
|---|---|
| Activation of ATR in response to replication stress | Homo sapiens |
| Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex | Homo sapiens |
| G2/M DNA damage checkpoint | Homo sapiens |
| Presynaptic phase of homologous DNA pairing and strand exchange | Homo sapiens |
| Processing of DNA double-strand break ends | Homo sapiens |
| Regulation of TP53 Activity through Phosphorylation | Homo sapiens |
| Signaling by SCF-KIT | Homo sapiens |
| TP53 Regulates Transcription of DNA Repair Genes | Homo sapiens |
| Transcriptional Regulation by E2F6 | Homo sapiens |
| Ubiquitin Mediated Degradation of Phosphorylated Cdc25A | Homo sapiens |
Disease
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:1793 | pancreatic cancer |
