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G2/M DNA damage checkpoint

Summary

Organism

Homo sapiens (human)

Reactome

R-HSA-69473

PubChem

R-HSA-69473

Description

Throughout the cell cycle, the genome is constantly monitored for damage, resulting either from errors of replication, by-products of metabolism or through extrinsic sources such as ultra-violet or ionizing radiation. The different DNA damage checkpoints act to inhibit or maintain the inhibition of the relevant CDK that will control the next cell cycle transition. The G2 DNA damage checkpoint prevents mitotic entry solely through T14Y15 phosphorylation of Cdc2 (Cdk1). Failure of the G2 DNA damage checkpoint leads to catastrophic attempts to segregate unrepaired chromosomes.

Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.

SPV: a JavaScript Signaling Pathway Visualizer, Bioinformatics, 2018

Displaying entries **1 - 10** of 44 in total

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UniProt ID	Protein Name	Gene Symbol	Pathway Viewer
O14757	Serine/threonine-protein kinase Chk1	CHEK1 CHK1	view
O60814	Histone H2B type 1-K	H2BC12 H2BFT HIRIP1 HIST1H2BK	view
O60934	Nibrin	NBN NBS NBS1 P95	view
O75943	Cell cycle checkpoint protein RAD17	R24L RAD17	view
O95714	E3 ubiquitin-protein ligase HERC2	HERC2	view
O96017	Serine/threonine-protein kinase Chk2	CDS1 CHEK2 CHK2 RAD53	view
O96028	Histone-lysine N-methyltransferase NSD2	KIAA1090 MMSET NSD2 TRX5 WHSC1	view
P04637	Cellular tumor antigen p53	P53 TP53	view
P06899	Histone H2B type 1-J	H2BC11 H2BFR HIST1H2BJ	view
P15927	Replication protein A 32 kDa subunit	REPA2 RPA2 RPA32 RPA34	view

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