Interleukin-1 signaling

Summary
Species
Homo sapiens
Reactome
PubChem
Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.
NF-kB complexNF-kB complexInterleukin-1IL1B,Myr82K-Myr83K-IL1A:IL1R1IL1R1IL1R2IL1B,Myr82K-Myr83K-IL1A:IL1R2IL1R1:IL1R2IL1R1:IL1R2:IL1RNIRAPIL-1R3IL1R1:IL1:IL1RAP2xMYD88IL1R1:IL1:IL1RAP:MYD88 dimerIRAK4IL1 receptor complexTOLLIPIL1 receptor complex:TOLLIPIL1 receptor complex - activated IRAK4:TOLLIPp-IRAK2IRAK2IRAK1IL1 receptor complex-activated IRAK4:TOLLIP:IRAK1ATPADPIL1 receptor complex- activated IRAK4:TOLLIP:p-IRAK1IL1 receptor complex- activated IRAK4:TOLLIP:hp-IRAK1IL1 receptor complex-activated IRAK4:TOLLIP:hp-IRAK:TRAF6TRAF6p62:MEKK3p62:MEKK3:TRAF6hp-IRAK1:TRAF6Activated IRAK4hp-IRAK1:3xTRAF6hp-IRAK1:3xTRAF6:3xUBE2N:UBE2V1:K63polyUbUBE2N:UBE2V1:K63polyUbhp-IRAK1:3xK63-polyUb-TRAF6:3xUBE2N:UBE2V1hp-IRAK1:3xK63polyUb-TRAF6TRIKA1TAK1 complexhp-IRAK1:K6-poly-Ub oligo-TRAF6:TAK1 complexhp-IRAK1:K63polyUboligo-TRAF6:Activated TAK1 complexhp-IRAK1, IRAK4hp-IRAK1:Pellino, IRAK4:PellinoPellino 1,2,3hp-IRAK1:p-Pellino, IRAK4:p-Pellinohp-IRAK1: p-Pellino-1,2,(3):UBE2N:UBE2V1:K63polyUbK63polyUb-hp-IRAK1:p-Pellino-1,2,(3):UBE2N:UBE2V1K63polyUb-hp-IRAK1p-Pellino-1,2,(3)Poly-K6-Ub-hp-IRAK1:IKK complexIKK complexIkBAp-S32,S36-IkBABTRC:CUL1:RBX1:SKP1NFKB p50:p65:phospho IKBA:SCF beta-TrCP complexNFKB p50:p65:phospho IKBAUbBTRC:CUL1:RBX1:SKP1:NFKB1:RELA:p-S32,S36-NFKBIA:UbNFKB1:RELA:p-S32,S36-NFKBIA:Ubp-S177,S181-IKKB:IKKA:NEMOIL1R1 inhibitorsIL1R1:IL1R1 inhibitorsMKK6p-S207,T211-MKK6IRAK1:Pellino:E2 complexes
ProteinProtein familyDNARNAComplexChemical/MoleculePhenotype/StimulusNucleusMitochondriaEndosomeGolgi apparatusLysosomeMembraneUp-regulatesDown-regulatesPhysical interactionUnknownDirectIndirectBindingHighlight
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GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01


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Last updated: April 7, 2025