Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE)

Summary
Species
Homo sapiens
Reactome
PubChem
Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.
phosphorylated IRF3/IRF7phosphorylated IRF3 and/or IRF7 dimerphosphorylated IRF3 and/or IRF7 dimerTRIF:TRAM:TLR4:LY96:LPS:CD14TRAF3:TRIF:activated TLR4TRAF3UbK63polyUb-TRAF3:TRIF:activated TLR4TANKTANK:K63-poly-Ub-TRAF3:TRIF:activated TLR4K63pUb-TANK:K63pUb-TRAF3:TRIF:activated TLR4IKKEactivated TLR4:TRIF:K63polyUb-TRAF3:K63polyUb-TANK:IKBKEactivated TLR4:TRIF:K63polyUb-TRAF3:K63polyUb-TANK:p-S172-IKBKEADPATPTBK1activated TLR4:TRIF:K63polyUb-TRAF3:K63polyUb-TANK:TBK1activated TLR4:TRIF:K63polyUb-TRAF3:K63polyUb-TANK:p-S-TBK1activated TLR4:TRIF:K63polyUb-TRAF3:K63polyUb-TANK:p-TBK1/p-IKBKEactivated TLR4:TRIF:K63polyUb-TRAF3:K63polyUb-TANK:p-TBK1/p-IKBKE:IRF3/IRF7IRF3,IRF7
ProteinProtein familyDNARNAComplexChemical/MoleculePhenotype/StimulusNucleusMitochondriaEndosomeGolgi apparatusLysosomeMembraneUp-regulatesDown-regulatesPhysical interactionUnknownDirectIndirectBindingHighlight
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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01


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