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MIRAGE
MyD88 dependent cascade initiated on endosome

Summary
Species
Homo sapiens
Reactome
PubChem
Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.
MYD88MyD88 complexed with the activated TLR receptorActivated TLR7-9 homodimersoligo-MyD88:activated TLR7-9IRAK4IRAK4:oligo-MyD88:activated TLR 7/8 or 9ATPADPp-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptorIRAK1, IRAK2IRAK1/or IRAK2 :p-S,2T-IRAK4:oligo-MyD88:activated TLR 7/8 or 9p-IRAK2:p-IRAK4:oligo-MyD88:activated TLR 7/8 or9IRAK2:p-S,2T-IRAK4:oligo-MyD88:activated TLR 7/8 or9p-IRAK1:p-IRAK4:oligo-MyD88:activated TLR7/8 or 9 complexIRAK1:p-S,2T-IRAK4 :oligo-MyD88:activated TLR 7/8 or 9pp-IRAK1:p-IRAK4:oligo-MyD88:activated TLR 7/8 or 9 complexp-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9TRAF6TRAF6:hp-IRAK1/or p-IRAK2:p-IRAK4:oligo-MyD88:activated TLR7/8 or 9hp-IRAK1 or p-IRAK2 bound to the pIRAK4:MyD88:activated TLR7/8 or 9 complex
ProteinProtein familyDNARNAComplexChemical/MoleculePhenotype/StimulusNucleusMitochondriaEndosomeGolgi apparatusLysosomeMembraneUp-regulatesDown-regulatesPhysical interactionUnknownDirectIndirectBindingHighlight
SPV: a JavaScript Signaling Pathway Visualizer, Bioinformatics, 2018
If you want to check the location of a particular molecule, you can do so by clicking on the "Switching Highlight" button on the page you have navigated to by clicking on "view".
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GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: February 17, 2025