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CHD1 and CHD2 subfamily

Summary

Organism

Homo sapiens (human)

Reactome

R-HSA-9943411

PubChem

R-HSA-9943411

Description

CHD subfamily I members CHD1 and CHD2 act as monomeric ATP-dependent chromatin remodellers (reviewed in Alendar and Berns, 2021; Clapier et al, 2017). Human CHD1 and CHD2 are characterized by the presence of double chromodomains at the N-terminal, and central SNF2 helicase ATPase domain, and a C-terminal SANT-SLIDE DNA binding domain (reviewed in Alendar and Berns, 2021; Li et al, 2023). They are 60% identical and 80% similar at the amino acid level (Liu et al, 2015) but have significantly divergent C-terminal regions that may contribute to different functions. Both proteins have been shown to bind to H3K4me3, albeit with different affinities (Sims et al, 2005; Sims et al, 2007; Flanagan et al 2007; Flanagan et al, 2005) and to possess in vitro and in vivo ATP-dependent chromatin remodelling activity (Luijsterberg et al, 2016, Tran et al, 2000; reviewed in Alendar and Berns, 2021; Li et al, 2023). Both proteins are associated with transcriptionally active regions of the genome and may play a role in histone H3.3 deposition (Harada et al, 2012; Konev et al, 2007; reviewed in Alendar and Berns, 2021).

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SPV: a JavaScript Signaling Pathway Visualizer, Bioinformatics, 2018

Displaying entries **1 - 10** of 52 in total

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UniProt ID	Protein Name	Gene Symbol	Pathway Viewer
O14646	ATP-dependent chromatin remodeler CHD1	CHD1	view
O14647	ATP-dependent chromatin remodeler CHD2	CHD2	view
O15042	U2 snRNP-associated SURP motif-containing protein	KIAA0332 SR140 U2SURP	view
O43143	ATP-dependent RNA helicase DHX15	DBP1 DDX15 DHX15	view
O60814	Histone H2B type 1-K	H2BC12 H2BFT HIRIP1 HIST1H2BK	view
O75533	Splicing factor 3B subunit 1	SAP155 SF3B1	view
O75940	Survival of motor neuron-related-splicing factor 30	SMNDC1 SMNR SPF30	view
P04908	Histone H2A type 1-B/E	H2AC4; H2AC8 H2AFA H2AFM HIST1H2AB HIST1H2AE	view
P06899	Histone H2B type 1-J	H2BC11 H2BFR HIST1H2BJ	view
P08579	U2 small nuclear ribonucleoprotein B''	SNRPB2	view

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