Antigen Presentation: Folding, assembly and peptide loading of class I MHC

Summary
Species
Mus musculus
Reactome
PubChem
Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.
Chaperones calnexin/BiPmonoglucosylated MHC class I HC:Calnexin/BiPmonoglucosylated MHC class I HCB2mMHC HC:B2M:Erp57MHC class I HC:Calnexin/BiP:Erp57TapbpMHC:B2M peptide loading complexBAP31 oligomerTAPCALRATPoligopeptideH2OPioligopeptideADPoligopeptideL-amino acidAntigenic peptide:MHC:B2M peptide loading complexErp57Antigen peptide bound class I MHC:BAP31 oligomerPeptide bound class I MHCSAR1B:GTPSAR1B:GTP:SEC23:SEC24SEC23:SEC24Sec13COPII vesicle with MHC class ISec31aSar1p:GTP:Sec23p:Sec24p:Ag bound MHC class ICOPII vesicle with MHC class ISEC23AGDPSAR1B:GDPAntigen peptide bound class I MHCSEC24GTPAntigen peptide bound class I MHCAntigen peptide bound class I MHC
ProteinProtein familyDNARNAComplexChemical/MoleculePhenotype/StimulusNucleusMitochondriaEndosomeGolgi apparatusLysosomeMembraneUp-regulatesDown-regulatesPhysical interactionUnknownDirectIndirectBindingHighlight
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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01


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Last updated: February 17, 2025