High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells

Summary
Species
Rattus norvegicus
Reactome
PubChem
Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.
PKA tetramerPKA tetramer:4xcAMPcAMPPRKACA,PRKACB,PRKACGcAMP:PKA regulatory subunitTRPV4 tetramerTRPV4 tetramer:CALM1:Ca2+CALM1:4xCa2+Ca2+Calpain2:Ca2+Calpain2VclVclP2ry2P2RY2:ATPATPPDPK1ADPATPO55173PKN2O08874AKT1:PIP3p-S473-AKT1:PIP3p-T308,S473-AKT1:PIP3palmitoylated, myristoylated eNOS dimerp-S1177-eNOS dimerp-S1177,S1179-eNOS dimerAdmAdmCALCRL:RAMP2ADM:CALCRL:RAMP2ADM:CALCLR:RAMP2:G-alpha(s):GDP:G-beta:G-gammaGDPGTPADM:CALCRL:RAMP2:G-alpha(s):GTP:G-beta:G-gammap-S633-eNOS dimer
ProteinProtein familyDNARNAComplexChemical/MoleculePhenotype/StimulusNucleusMitochondriaEndosomeGolgi apparatusLysosomeMembraneUp-regulatesDown-regulatesPhysical interactionUnknownDirectIndirectBindingHighlight
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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01


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Last updated: April 7, 2025