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Nitric oxide synthase 3
Summary
- UniProt ID
- Q62600
- Gene Symbol
-
- Nos3
- Gene ID
- 24600
- Organism
- Rattus norvegicus (Norway rat)
Annotation
- Keyword
-
- Calcium
- Calmodulin-binding
- Cell membrane
- Cytoskeleton
- FAD
- FMN
- Golgi apparatus
- Heme
- Myristate
- NADP
- Oxidoreductase
- Palmitate
- Phosphoprotein
- Reference proteome
- Zinc
- Gene Ontology (GO)
| GO Term |
|---|
| nucleus |
| cytoplasm |
| cytoskeleton |
| plasma membrane |
| Golgi apparatus |
| cytosol |
| sarcolemma |
| apical part of cell |
| caveola |
| GO Term |
|---|
| metal ion binding |
| nitric-oxide synthase activity |
| tetrahydrobiopterin binding |
| arginine binding |
| actin binding |
| actin monomer binding |
| calmodulin binding |
| FMN binding |
| heme binding |
| cadherin binding |
Sequence
MGNLKSVGQEPGPPCGLGLGLGLGLCGKQGPASPAPEPSQAPVPPSPTRPAPDHSPPLTRPPDGPKFPRVKNWEVGSITYDTLSAQAQQDGPCTPRRCLGSLVFPRKLQSRPTQGPSPTEQLLGQARDFINQYYNSIKRSGSQAHEQRLQEVEAEVVATGTYQLRESELVFGAKQAWRNAPRCVGRIQWGKLQVFDARDCRTAQEMFTYICNHIKYATNRGNLRSAITVFPQRYAGRGDFRIWNSQLVRYAGYRQQDGSVRGDPANVEITELCIQHGWTPGNGRFDVLPLLLQAPDEPPELFTLPPELVLEVPLEHPTLEWFAALGLRWYALPAVSNMLLEIGGLEFPAAPFSGWYMSSEIGMRDLCDPHRYNILEDVAVCMDLDTRTTSSLWKDKAAVEINVAVLYSYQLAKVTIVDHHAATASFMKHLENEQKARGGCPADWAWIVPPISGSLTPVFHQEMVNYFLSPAFRYQPDPWKGSAAKGTGITRKKTFKEVANAVKISASLMGTVMAKRVKATILYGSETGRAQSYAQQLGRLFRKAFDPRVLCMDEYDVVSLEHEALVLVVTSTFGNGDPPENGESFAAALMEMSGPYNSSPRPEQHKSYKIRFNSVSCSDPLVSSWRRKRKESSNTDSAGALGTLRFCVFGLGSRAYPHFCAFARAVDTRLEELGGERLLQLGQGDELCGQEEAFRGWAQAAFQAACETFCVGEDAKAAARDIFSPKRSWKRQRYRLSTQAESLQLLPRLTHVHRRKMFQATILSVENLQSSKSTRATILVRLDTGSQEGLQYQPGDHIGVCPPNRPGLVEALLSRVEDPPPSTEPVAVEQLEKGSPGGPPPGWVRDPRLPPCTLRQALTYFLDITSPPSPRLLRLLSTLAEESSEQQELEALSQDPRRYEEWKWFRCPTLLEVLEQFPSVALPAPLILTQLPLLQPRYYSVSSAPSAHPGEIHLTVAVLAYRTQDGLGPLHYGVCSTWMSQLKAGDPVPCFIRGAPSFRLPPDPNLPCILVGPGTGIAPFRGFWQDRLHDIEIKGLQPAPMTLVFGCRCSQLDHLYRDEVLDAQQRGVFGQVLTAFSRDPGSPKTYVQDLLRTELAAEVHRVLCLEQGHMFVCGDVTMATSVLQTVQRILATEGSMELDEAGDVIGVLRDQQRYHEDIFGLTLRTQEVTSRIRTQSFSLQERQLRGAVPWSFDPPTQETPGS
Glycosylation Sites
| Position | Description | PubMed ID | GlyTouCan ID | Source |
|---|---|---|---|---|
| 119 |
|
|
||
| 1178 |
|
G49108TO
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Pathway
| Pathway Name | Organism |
|---|---|
| Extra-nuclear estrogen signaling | Rattus norvegicus |
| High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells | Rattus norvegicus |
| NOSIP mediated eNOS trafficking | Rattus norvegicus |
| NOSTRIN mediated eNOS trafficking | Rattus norvegicus |
| Nitric oxide stimulates guanylate cyclase | Rattus norvegicus |
| ROS and RNS production in phagocytes | Rattus norvegicus |
| Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation | Rattus norvegicus |
| VEGFR2 mediated vascular permeability | Rattus norvegicus |
| eNOS activation | Rattus norvegicus |
Disease
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0050852 | limb ischemia | |
| DOID:1073 | renal hypertension | |
| DOID:10762 | portal hypertension | |
| DOID:10763 | hypertension | |
| DOID:224 | transient cerebral ischemia | |
| DOID:2316 | brain ischemia | |
| DOID:5082 | liver cirrhosis | |
| DOID:5844 | myocardial infarction | |
| DOID:6432 | pulmonary hypertension | |
| DOID:8466 | retinal degeneration |
