GlyCosmos Portal

GlyCosmos Pathways

Integrated of pathway data, containing glycoproteins and glycans obtained from Reactome and the Metabolism of carbohydrates in Escherichia coli O-antigens obtained from ECODAB. Search by pathway name, species, and protein name.

Source	Last Updated
Reactome	March 20, 2024
ECODAB	April 1, 2019

Displaying entries **251 - 275** of **499** in total

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Pathway Name	Protein Name	UniProt ID	Gene Symbol ▼	Organism
Degradation of the extracellular matrix	Cathepsin L-like Contactin rig-6 Disintegrin and metalloproteinase domain-containing protein adm-2 Disintegrin and metalloproteinase domain-containing protein unc-71 Ig-like domain-containing protein Kringle domain-containing protein MMP-like protein Matrix metalloproteinase-A Matrix metalloproteinase-B Matrix metalloproteinase-C Peptidase M12B domain-containing protein Peptidase metallopeptidase domain-containing protein Titin homolog Uncharacterized protein Zinc metalloproteinase nas-39	C6KRM7 G4SLH0 G5EBU3 G5ECC4 G5EDW5 G5EFD5 G5EGM1 H2KZ60 O17913 O44836 O45734 P91823 Q20176 Q21182 Q9N5X7	CELE_K03B8.6 CELE_T22A3.6 adm-1 adm-2 cpl-1 nas-39 rig-5 rig-6 tag-275 ttn-1 unc-71 zmp-1 zmp-2 zmp-3 zmp-5 zmp-6	Caenorhabditis elegans
COPI-dependent Golgi-to-ER retrograde traffic	ADP-ribosylation factor 1-like 1 ADP-ribosylation factor 1-like 2 ADP-ribosylation factor Alpha-soluble NSF attachment protein Arf-GAP domain-containing protein Centromere/kinetochore protein zw10 homolog Coatomer subunit alpha Coatomer subunit beta Coatomer subunit epsilon DUF727 domain-containing protein E3 ubiquitin-protein ligase arc-1 ER lumen protein-retaining receptor erd-2.1 ER lumen protein-retaining receptor erd-2.2 GOLD domain-containing protein Gamma-soluble NSF attachment protein Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 homolog Kinesin heavy chain Kinesin light chain Kinesin light chain Kinesin motor domain-containing protein Kinesin motor domain-containing protein Kinesin-associated protein Kinesin-like protein klp-12 Kinesin-like protein klp-19 Kinesin-like protein klp-20 Kinesin-like protein unc-104 Kinesin-like protein unc-104 Kinesin-like protein vab-8 Kinesin-like protein Kinesin-like protein Kinesin-like protein Kinesin-like protein Kinesin-like protein Kinesin-like protein Neuroblastoma-amplified sequence Probable coatomer subunit beta' Probable coatomer subunit delta Probable coatomer subunit gamma Probable coatomer subunit zeta RAB family Rac GTPase-activating protein 1 Suppressor/enhancer of lin-12 protein 9 Surfeit locus protein 4 homolog Transmembrane emp24 domain-containing protein bai Uncharacterized protein F07F6.4 Vesicle transport protein SEC20 Vesicle transport protein USE1 Vesicle-fusing ATPase Vesicle-trafficking protein SEC22b t-SNARE coiled-coil homology domain-containing protein	A0A4V0IKG7 C0Z1Y7 G5EBX0 G5ECF4 G5EEE6 G5EFK4 G5EFQ4 G5EGS3 G5EGS5 H9G2T2 O17528 O17901 O44738 O45935 O62246 O76413 P23678 P34540 P46822 P48583 P90841 P90904 P91400 Q09236 Q09473 Q09531 Q09654 Q10943 Q18864 Q18921 Q19633 Q19642 Q1RPT8 Q20168 Q20546 Q21441 Q22498 Q8MQ03 Q8MQ20 Q94231 Q94241 Q94392 Q965T6 Q9N4H7 Q9N598 Q9NEQ8 Q9TYL9 Q9UAQ6 Q9XU12 Q9XUS9	CELE_K02B12.7 CELE_Y59A8B.25 CELE_Y59A8B.8 F07F6.4 Y110A7A.11 arc-1 arf-1 arf-1.1 arf-1.2 arf-3 arf-5 arl-4 arl-6 bmk-1 copa-1 copb-1 copb-2 copd-1 cope-1 copg-1 copz-1 cyk-4 czw-1 erd-2 erd-2.1 erd-2.2 gbf-1 kap-1 khc-1 klc-1 klc-2 klp-11 klp-12 klp-13 klp-15 klp-18 klp-19 klp-20 klp-4 klp-6 klp-7 nsf-1 phi-34 rab-1 sec-20 sec-22 sel-9 sft-4 smgl-1 snap-1 surf-4 syx-18 tmed-10 tmed-3 unc-104 unc-116 vab-8 zen-4	Caenorhabditis elegans
Regulation of KIT signaling	Discoidin domain-containing receptor tyrosine kinase B E3 ubiquitin-protein ligase CBL Protein kinase C-like 2 Protein kinase domain-containing protein Protein kinase domain-containing protein Sex muscle abnormal protein 5 Son of sevenless homolog	A0A1I6CMA1 P29355 P90980 Q19019 Q21046 Q95ZV7 Q9N5D3	CELE_F59F5.3 ddr-2 kin-11 kin-36 let-341 pkc-2 sem-5 sli-1 sos-1 svh-4	Caenorhabditis elegans
FLT3 Signaling	Discoidin domain-containing receptor tyrosine kinase B Forkhead box protein O Protein kinase domain-containing protein Protein kinase domain-containing protein Ras protein let-60 Serine/threonine-protein kinase akt-1 Serine/threonine-protein kinase akt-2 Sex muscle abnormal protein 5 Son of sevenless homolog	A0A1I6CMA1 O16850 P22981 P29355 Q17941 Q21046 Q95ZV7 Q9N5D3 Q9XTG7	CELE_F59F5.3 akt-1 akt-2 daf-16 ddr-2 kin-36 let-341 let-60 lin-34 sem-5 sos-1 svh-4	Caenorhabditis elegans
Signaling by SCF-KIT	Discoidin domain-containing receptor tyrosine kinase B Phosphatidylinositol 3-kinase age-1 Phosphoinositide 3-kinase adapter subunit Protein kinase domain-containing protein Protein kinase domain-containing protein Protein vav-1 Ras protein let-60 Ras-related protein ced-10 Sex muscle abnormal protein 5 Son of sevenless homolog	A0A1I6CMA1 G5EDP9 P22981 P29355 Q03206 Q21046 Q45FX5 Q94125 Q95ZV7 Q9N5D3	CELE_F59F5.3 aap-1 age-1 ced-10 ddr-2 kin-36 let-341 let-60 lin-34 rac-1 sem-5 sos-1 svh-4 vav-1	Caenorhabditis elegans
Downstream signal transduction	Cell death abnormality protein 2 Discoidin domain-containing receptor tyrosine kinase B NCK (Non-Catalytic region of tyrosine Kinase) adaptor protein family Phosphatidylinositol 3-kinase age-1 Phosphoinositide 3-kinase adapter subunit Platelet-derived growth factor (PDGF) family profile domain-containing protein Protein kinase domain-containing protein Protein kinase domain-containing protein Protein kinase domain-containing protein Ras protein let-60 SH2 domain-containing protein Sex muscle abnormal protein 5 Signal transducer and activator of transcription 1 Signal transducer and activator of transcription b Son of sevenless homolog Tyrosine protein-kinase src-1	A0A1I6CMA1 D3YT30 G5EDP9 G5EE56 P22981 P29355 Q20977 Q21046 Q94125 Q95PX0 Q95XA9 Q95ZV7 Q9N413 Q9N5D3 Q9NAD6 Q9NHC3	CELE_F59F5.3 CELE_T12G3.2 aap-1 age-1 ced-2 ddr-2 gap-3 kin-36 let-341 let-60 lin-34 nck-1 pvf-1 sem-5 sos-1 src-1 sta-1 sta-2 stat-b svh-4	Caenorhabditis elegans
Sphingolipid de novo biosynthesis	3-dehydrosphinganine reductase ABC transporter domain-containing protein ABC transporter family G domain-containing protein BED-type domain-containing protein Casein kinase I gamma Ceramide synthase hyl-1 Ceramide synthase hyl-2 Cytochrome b5 heme-binding domain-containing protein Cytochrome b5 heme-binding domain-containing protein Fatty acid 2-hydroxylase Glycolipid transfer protein domain-containing protein Major facilitator superfamily (MFS) profile domain-containing protein Major facilitator superfamily (MFS) profile domain-containing protein Major facilitator superfamily (MFS) profile domain-containing protein Major facilitator superfamily (MFS) profile domain-containing protein Multidrug resistance-associated protein 1 Oxysterol-binding protein Phosphatidylcholine Phosphatidylcholine Probable ceramide synthase lagr-1 Putative phosphatidylcholine Putative sphingolipid delta(4)-desaturase/C4-monooxygenase Putative sphingolipid delta(4)-desaturase Serine/threonine-protein kinase dkf-1 Serine/threonine-protein kinase dkf-2 Sphingomyelin synthase-related 1 Sphingomyelin synthase-related 2 Sphingosine kinase 1	A0A3B1DV80 A0A5K1IBA7 A7DTF2 D7SFK1 G5EC63 G5ED45 O01927 O44186 O45818 Q18425 Q18545 Q19235 Q19585 Q20696 Q20735 Q20976 Q3S1M2 Q7Z139 Q8WQ99 Q93315 Q965Q4 Q9BKS2 Q9TYV2 Q9U3D4 Q9XUJ7 Q9XVS0 Q9XWE9 U4PBL3	CELE_F58B4.2 CELE_Y37E11AM.3 CELE_Y82E9BR.14 F33D4.4 F53B1.2 abcx-1 bed-2 csnk-1 cytb-5.1 dkf-1 dkf-2 fath-1 hyl-1 hyl-2 lagr-1 mrp-1 obr-1 sms-1 sms-2 sms-3 sms-5 sphk-1 spin-1 spin-2 spin-3 spin-4 tag-274 ttm-5 wht-5	Caenorhabditis elegans
Inactivation, recovery and regulation of the phototransduction cascade	Beta-arrestin arr-1 Cyclic nucleotide-binding domain-containing protein Cyclic nucleotide-binding domain-containing protein Cyclic nucleotide-binding domain-containing protein Cyclic nucleotide-binding domain-containing protein Cyclic nucleotide-binding domain-containing protein Cyclic nucleotide-gated cation channel EF-hand domain-containing protein G protein-coupled receptor kinase 1 G-protein coupled receptors family 1 profile domain-containing protein Guanine nucleotide-binding protein subunit gamma Neuronal calcium sensor 2 Protein farnesyltransferase subunit beta Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha Receptor-type guanylate cyclase daf-11 Receptor-type guanylate cyclase gcy-10 Receptor-type guanylate cyclase gcy-11 Receptor-type guanylate cyclase gcy-12 Receptor-type guanylate cyclase gcy-13 Receptor-type guanylate cyclase gcy-14 Receptor-type guanylate cyclase gcy-15 Receptor-type guanylate cyclase gcy-17 Receptor-type guanylate cyclase gcy-18 Receptor-type guanylate cyclase gcy-19 Receptor-type guanylate cyclase gcy-1 Receptor-type guanylate cyclase gcy-20 Receptor-type guanylate cyclase gcy-21 Receptor-type guanylate cyclase gcy-22 Receptor-type guanylate cyclase gcy-23 Receptor-type guanylate cyclase gcy-25 Receptor-type guanylate cyclase gcy-27 Receptor-type guanylate cyclase gcy-29 Receptor-type guanylate cyclase gcy-2 Receptor-type guanylate cyclase gcy-3 Receptor-type guanylate cyclase gcy-4 Receptor-type guanylate cyclase gcy-5 Receptor-type guanylate cyclase gcy-6 Receptor-type guanylate cyclase gcy-7 Receptor-type guanylate cyclase gcy-8 Receptor-type guanylate cyclase gcy-9 Serine/threonine-protein phosphatase with EF-hands pef-1	A0A078BQP2 A8WI01 B1Q257 E7EAU8 G5EBX9 G5EEE2 G5EEE9 G5EFQ0 H2L002 N1NVB7 O01818 O16544 O16715 O44501 O61827 O62026 O62179 P36609 P51485 P54406 P91550 Q03611 Q09435 Q09537 Q10028 Q10029 Q18136 Q18331 Q19187 Q19752 Q19768 Q23310 Q23681 Q23682 Q7Z205 Q8I4N4 Q9GYQ4 Q9N4C1 Q9XTY1 Q9XU42 X5M8U1	CELE_F57C9.6 arr-1 cal-5 che-6 cng-1 cng-2 cng-3 daf-11 fnta-1 fntb-1 gcy-1 gcy-10 gcy-11 gcy-12 gcy-13 gcy-14 gcy-15 gcy-16 gcy-17 gcy-18 gcy-19 gcy-2 gcy-20 gcy-21 gcy-22 gcy-23 gcy-25 gcy-27 gcy-29 gcy-3 gcy-4 gcy-5 gcy-6 gcy-7 gcy-8 gcy-9 gpc-1 grk-1 ncs-2 odr-1 pef-1 tax-2 tax-4	Caenorhabditis elegans
Pre-NOTCH Processing in Golgi	CUB domain-containing protein EGF-like domain-containing protein Protein lin-12 Suppressor/enhancer of lin-12 protein 9	O17528 P14585 P90891 Q21850	CELE_F55H12.3 CELE_R08E3.1 lin-12 sel-9	Caenorhabditis elegans
NOTCH4 Activation and Transmission of Signal to the Nucleus	14-3-3-like protein 1 14-3-3-like protein 2 CUB domain-containing protein EGF-like domain-containing protein Protein lin-12	P14585 P41932 P90891 Q20655 Q21850	CELE_F55H12.3 CELE_R08E3.1 ftt-1 ftt-2 lin-12 par-5	Caenorhabditis elegans
Negative regulation of NOTCH4 signaling	CUB domain-containing protein EGF-like domain-containing protein Protein lin-12 Serine/threonine-protein kinase akt-1 Serine/threonine-protein kinase akt-2	P14585 P90891 Q17941 Q21850 Q9XTG7	CELE_F55H12.3 CELE_R08E3.1 akt-1 akt-2 lin-12	Caenorhabditis elegans
Class A/1 (Rhodopsin-like receptors)	G-protein coupled receptors family 1 profile domain-containing protein G-protein coupled receptors family 1 profile domain-containing protein G-protein coupled receptors family 1 profile domain-containing protein G_PROTEIN_RECEP_F1_2 domain-containing protein G_PROTEIN_RECEP_F1_2 domain-containing protein	H2KZ99 O18014 Q19779 Q1ZXT2 Q20827	CELE_F55D10.4 ador-1 gnrr-4 gtr-1 npr-25	Caenorhabditis elegans
G alpha (s) signalling events	Bursicon Dopamine receptor 2 G protein gamma domain-containing protein G-protein coupled receptors family 1 profile domain-containing protein G-protein coupled receptors family 1 profile domain-containing protein G-protein coupled receptors family 1 profile domain-containing protein G-protein coupled receptors family 1 profile domain-containing protein G-protein coupled receptors family 1 profile domain-containing protein G-protein coupled receptors family 1 profile domain-containing protein G-protein coupled receptors family 1 profile domain-containing protein G-protein coupled receptors family 1 profile domain-containing protein G-protein coupled receptors family 1 profile domain-containing protein G_PROTEIN_RECEP_F1_2 domain-containing protein G_PROTEIN_RECEP_F1_2 domain-containing protein Glycoprotein hormone subunit beta domain-containing protein Guanine nucleotide-binding protein G(s) subunit alpha Guanine nucleotide-binding protein subunit beta-1 Guanine nucleotide-binding protein subunit beta-2 Guanine nucleotide-binding protein subunit gamma Probable 3',5'-cyclic phosphodiesterase pde-1 Probable 3',5'-cyclic phosphodiesterase pde-2 Probable 3',5'-cyclic phosphodiesterase pde-3 Probable 3',5'-cyclic phosphodiesterase pde-5 Probable 3',5'-cyclic phosphodiesterase pde-6 Probable 3',5'-cyclic-AMP phosphodiesterase pde-4	A7DT38 E7EM37 G5ECT6 G5EGH0 H2KZ99 L8EC40 O18014 O18696 P17343 P30645 P54406 P91119 Q17553 Q19779 Q1ZXT2 Q20636 Q20827 Q21013 Q22000 Q22895 Q7KPV0 Q86ME6 Q8I0P7 Q9N2V9 Q9XUK8	CELE_F55D10.4 ador-1 dop-1 dop-2 dop-2L eat-11 flr-2 fshr-1 gbp-2 gnrr-4 gpb-1 gpb-2 gpb5 gpc-1 gpc-2 gplb-1 gsa-1 gtr-1 npr-14 npr-25 npr-42 pde-1 pde-2 pde-3 pde-4 pde-5 pde-6 ser-4 ser-7	Caenorhabditis elegans
Surfactant metabolism	ABC transporter domain-containing protein Aspartic protease 4 G-protein coupled receptors family 1 profile domain-containing protein GATA-type domain-containing protein GATA-type domain-containing protein G_PROTEIN_RECEP_F1_2 domain-containing protein G_PROTEIN_RECEP_F1_2 domain-containing protein Saposin B-type domain-containing protein Saposin B-type domain-containing protein Sodium-dependent phosphate transport protein 2B TEStin (Human testis-derived transcript) homolog Transcription factor elt-1 Transcription factor elt-2 Transcription factor elt-6 Transcription factor elt-7	G5EF25 G5EF71 G5EGN3 O61924 P28515 Q10655 Q17525 Q18276 Q18279 Q19779 Q1ZXT2 Q20827 Q21966 Q23530 Q9TXV8	CELE_F55D10.4 CELE_ZK563.2 abt-4 ador-1 asp-4 elt-1 elt-2 elt-6 elt-7 gtr-1 med-1 med-2 spp-10 spp-8 tes-1	Caenorhabditis elegans
RHO GTPases activate PKNs	14-3-3-like protein 1 14-3-3-like protein 2 M-phase inducer phosphatase cdc-25.1 M-phase inducer phosphatase cdc-25.2 M-phase inducer phosphatase cdc-25.3 M-phase inducer phosphatase Protein phosphatase 1 regulatory subunit 14B Ras-like GTP-binding protein rhoA Ras-related protein ced-10 Serine/threonine-protein phosphatase PP1-alpha cGMP-dependent protein kinase interacting domain-containing protein non-specific serine/threonine protein kinase protein kinase C	A0A4V0ILM7 G5ECD7 O44552 O44628 P30634 P41932 Q03206 Q20655 Q21762 Q22038 Q27497 Q7YX00 Q9UA62	CELE_F55C10.5 CELE_W04B5.5 cdc-25.1 cdc-25.2 cdc-25.3 cdc-25.4 ced-10 ftt-1 ftt-2 gsp-1 mel-11 par-5 pkn-1 rac-1 rho-1 rhoa	Caenorhabditis elegans
Melanin biosynthesis	Putative tyrosinase-like protein tyr-1 Putative tyrosinase-like protein tyr-3 ShKT domain-containing protein ShKT domain-containing protein ShKT domain-containing protein Tyrosinase copper-binding domain-containing protein Tyrosinase copper-binding domain-containing protein	O01497 O76708 P34269 Q19673 Q93787 Q95XC6 Q9XUS8	CELE_F54E4.4 tyr-1 tyr-2 tyr-3 tyr-4 tyr-5 tyr-6	Caenorhabditis elegans
VxPx cargo-targeting to cilium	Cyclic nucleotide-binding domain-containing protein Cyclic nucleotide-binding domain-containing protein Cyclic nucleotide-binding domain-containing protein Cyclic nucleotide-binding domain-containing protein Cyclic nucleotide-binding domain-containing protein Cyclic nucleotide-gated cation channel Exocyst complex component 1 Exocyst complex component 2 Exocyst complex component 3 Exocyst complex component 4 Exocyst complex component 5 Exocyst complex component 6 Exocyst complex component 7 Exocyst component Exo84 C-terminal domain-containing protein FIP-RBD domain-containing protein G-protein coupled receptors family 1 profile domain-containing protein GDP/GTP exchange factor Sec2 N-terminal domain-containing protein Polycystin-2 RAB family Rab8 Ras-related protein rab-11.1	A8WI01 G5EEE2 G5EFC1 O01803 O01818 O61827 P91149 Q03611 Q18286 Q18406 Q19262 Q20678 Q20759 Q21137 Q22706 Q7Z205 Q95Q35 Q95ZS6 Q9N4C1 Q9U1S7 Q9XWS2	CELE_F54C9.11 CELE_F57C9.6 che-6 cng-1 cng-2 cng-3 exoc-7 exoc-8 pdk-2 pkd-2 rab-11.1 rab-8 rab8 rabr-1 rfip-1 sec-10 sec-15 sec-3 sec-5 sec-6 sec-8 tax-2 tax-4	Caenorhabditis elegans
Formation of TC-NER Pre-Incision Complex	BSD domain-containing protein CDK-activating kinase assembly factor MAT1 COP9 signalosome complex subunit 1 COP9 signalosome complex subunit 2 COP9 signalosome complex subunit 3 COP9 signalosome complex subunit 4 COP9 signalosome complex subunit 5 COP9 signalosome complex subunit 6 Cullin-4 Cyclin-dependent kinase 7 DNA damage-binding protein 1 DNA repair and recombination protein RAD54-like DNA-directed RNA polymerase II subunit RPB1 DNA-directed RNA polymerase II subunit RPB2 DNA-directed RNA polymerase II subunit RPB7 DNA-directed RNA polymerase II subunit rpb-9 DNA-directed RNA polymerase RpoA/D/Rpb3-type domain-containing protein DNA-directed RNA polymerases I, II, and III subunit RPABC1 DNA-directed RNA polymerases I, II, and III subunit RPABC4 DNA-directed RNA polymerases I, II, and III subunit RPABC5 General transcription and DNA repair factor IIH helicase subunit XPB General transcription and DNA repair factor IIH helicase subunit XPD General transcription and DNA repair factor IIH subunit TFB5 General transcription factor IIH subunit 2 General transcription factor IIH subunit 3 General transcription factor IIH subunit 4 Intron-binding protein aquarius Polyubiquitin-A Pre-mRNA-processing factor 19 Pre-mRNA-splicing factor SYF1 Probable DNA-directed RNA polymerase II subunit RPB11 Probable DNA-directed RNA polymerases I, II, and III subunit RPABC2 Probable DNA-directed RNA polymerases I, II, and III subunit RPABC3 Protein isy-1 Putative transcription elongation factor S-II RING-box protein 1 RNA polymerase Rpb4/RPC9 core domain-containing protein UV-stimulated scaffold protein A homolog Ubiquitin carboxyl-terminal hydrolase 7 Ubiquitin-like protein 1-ribosomal protein eS31 fusion protein Ubiquitin-ribosomal protein eL40 fusion protein WD_REPEATS_REGION domain-containing protein XPA C-terminal domain-containing protein Zinc finger protein 830	G5EFV5 K8F7X5 O01422 O02092 O17245 O44499 P0CG71 P16356 P34567 P37165 P49632 P52652 P91001 P91175 Q09645 Q10051 Q10578 Q17392 Q17684 Q18963 Q19826 Q20716 Q21302 Q21554 Q22139 Q23088 Q23457 Q7JKC3 Q86D18 Q93338 Q95PZ0 Q95PZ4 Q965S0 Q9GR61 Q9GS00 Q9N359 Q9N390 Q9N3C9 Q9N3L2 Q9N425 Q9N5K2 Q9U1Q7 Q9U3I0 Q9XVH6	CELE_F53H4.6 T24H10.1 ama-1 cdk-7 csa-1 csn-1 csn-2 csn-3 csn-4 csn-5 csn-6 cul-4 ddb-1 emb-4 gtf-2H1 gtf-2H2C gtf-2H3 gtf-2H4 gtf-2H5 gtf-2h1 gtf-2h3 isy-1 math-33 mnat-1 prp-19 rbx-1 rpb-1 rpb-10 rpb-11 rpb-12 rpb-2 rpb-3 rpb-4 rpb-5 rpb-6 rpb-7 rpb-8 rpb-9 sel-13 syf-1 ubia ubib ubl-1 ubq-1 ubq-2 usp-7 uvs-1 xpa-1 xpb-1 xpd-1	Caenorhabditis elegans
Gap-filling DNA repair synthesis and ligation in TC-NER	BSD domain-containing protein CDK-activating kinase assembly factor MAT1 Cullin-4 Cyclin-dependent kinase 7 DNA damage-binding protein 1 DNA ligase 1 DNA polymerase delta catalytic subunit DNA polymerase delta subunit 3 DNA polymerase epsilon catalytic subunit DNA polymerase epsilon subunit 3 DNA polymerase kappa DNA repair and recombination protein RAD54-like DNA-directed RNA polymerase II subunit RPB1 DNA-directed RNA polymerase II subunit RPB2 DNA-directed RNA polymerase II subunit RPB7 DNA-directed RNA polymerase II subunit rpb-9 DNA-directed RNA polymerase RpoA/D/Rpb3-type domain-containing protein DNA-directed RNA polymerases I, II, and III subunit RPABC1 DNA-directed RNA polymerases I, II, and III subunit RPABC4 DNA-directed RNA polymerases I, II, and III subunit RPABC5 General transcription and DNA repair factor IIH helicase subunit XPB General transcription and DNA repair factor IIH helicase subunit XPD General transcription and DNA repair factor IIH subunit TFB5 General transcription factor IIH subunit 2 General transcription factor IIH subunit 3 General transcription factor IIH subunit 4 Intron-binding protein aquarius Polyubiquitin-A Pre-mRNA-processing factor 19 Pre-mRNA-splicing factor SYF1 Probable DNA polymerase delta small subunit Probable DNA polymerase epsilon subunit 2 Probable DNA-directed RNA polymerase II subunit RPB11 Probable DNA-directed RNA polymerases I, II, and III subunit RPABC2 Probable DNA-directed RNA polymerases I, II, and III subunit RPABC3 Probable replication factor A 73 kDa subunit Probable replication factor C subunit 5 Proliferating cell nuclear antigen Protein isy-1 Putative transcription elongation factor S-II RING-box protein 1 RNA polymerase Rpb4/RPC9 core domain-containing protein RPA_C domain-containing protein Replication factor C subunit 1 Replication factor C subunit 2 Replication factor C subunit 3 Replication factor C subunit 4 UV-stimulated scaffold protein A homolog Ubiquitin carboxyl-terminal hydrolase 7 Ubiquitin-like protein 1-ribosomal protein eS31 fusion protein Ubiquitin-ribosomal protein eL40 fusion protein WD_REPEATS_REGION domain-containing protein Zinc finger protein 830	G5EFV5 K8F7X5 O02092 O02115 O17245 O44175 O44499 O62218 P0CG71 P16356 P34409 P34429 P34567 P37165 P49632 P52652 P53016 P90829 P91175 P91356 Q09645 Q10051 Q10578 Q17392 Q17684 Q18547 Q18841 Q18963 Q19196 Q19366 Q19537 Q19826 Q20716 Q21554 Q21730 Q22139 Q22798 Q23088 Q23457 Q27474 Q7JKC3 Q86D18 Q93338 Q95PZ4 Q965S0 Q9GR61 Q9N390 Q9N3C9 Q9N3L2 Q9N5K2 Q9U1Q7 Q9U3I0 Q9XVH6	CELE_F53H4.6 CELE_R04F11.3 CELE_T26A5.8 F10C2.4 F12F6.7 F44B9.8 T24H10.1 ama-1 cdk-7 csa-1 cul-4 ddb-1 emb-4 gtf-2H1 gtf-2H2C gtf-2H3 gtf-2H4 gtf-2H5 gtf-2h1 gtf-2h3 isy-1 lig-1 math-33 mnat-1 pcn-1 pole-1 pole-2 polk-1 prp-19 rbx-1 rfc-1 rfc-2 rfc-3 rfc-4 rpa-1 rpa-4 rpb-1 rpb-10 rpb-11 rpb-12 rpb-2 rpb-3 rpb-4 rpb-5 rpb-6 rpb-7 rpb-8 rpb-9 sel-13 syf-1 ubia ubib ubl-1 ubq-1 ubq-2 usp-7 uvs-1 xpb-1 xpd-1	Caenorhabditis elegans
Dual incision in TC-NER	BSD domain-containing protein CDK-activating kinase assembly factor MAT1 Cullin-4 Cyclin-dependent kinase 7 DNA damage-binding protein 1 DNA polymerase delta catalytic subunit DNA polymerase delta subunit 3 DNA polymerase epsilon catalytic subunit DNA polymerase epsilon subunit 3 DNA polymerase kappa DNA repair and recombination protein RAD54-like DNA-directed RNA polymerase II subunit RPB1 DNA-directed RNA polymerase II subunit RPB2 DNA-directed RNA polymerase II subunit RPB7 DNA-directed RNA polymerase II subunit rpb-9 DNA-directed RNA polymerase RpoA/D/Rpb3-type domain-containing protein DNA-directed RNA polymerases I, II, and III subunit RPABC1 DNA-directed RNA polymerases I, II, and III subunit RPABC4 DNA-directed RNA polymerases I, II, and III subunit RPABC5 ERCC1-like central domain-containing protein ERCC4 domain-containing protein General transcription and DNA repair factor IIH helicase subunit XPB General transcription and DNA repair factor IIH helicase subunit XPD General transcription and DNA repair factor IIH subunit TFB5 General transcription factor IIH subunit 2 General transcription factor IIH subunit 3 General transcription factor IIH subunit 4 Intron-binding protein aquarius Polyubiquitin-A Pre-mRNA-processing factor 19 Pre-mRNA-splicing factor SYF1 Probable DNA polymerase delta small subunit Probable DNA polymerase epsilon subunit 2 Probable DNA-directed RNA polymerase II subunit RPB11 Probable DNA-directed RNA polymerases I, II, and III subunit RPABC2 Probable DNA-directed RNA polymerases I, II, and III subunit RPABC3 Probable replication factor A 73 kDa subunit Probable replication factor C subunit 5 Proliferating cell nuclear antigen Protein isy-1 Putative transcription elongation factor S-II RING-box protein 1 RNA polymerase Rpb4/RPC9 core domain-containing protein RPA_C domain-containing protein Replication factor C subunit 1 Replication factor C subunit 2 Replication factor C subunit 3 Replication factor C subunit 4 UV-stimulated scaffold protein A homolog Ubiquitin carboxyl-terminal hydrolase 7 Ubiquitin-like protein 1-ribosomal protein eS31 fusion protein Ubiquitin-ribosomal protein eL40 fusion protein WD_REPEATS_REGION domain-containing protein XPA C-terminal domain-containing protein Zinc finger protein 830	G5EBZ1 G5EFV5 K8F7X5 O02092 O02115 O17245 O44175 O44499 O62218 P0CG71 P16356 P34409 P34429 P34567 P37165 P49632 P52652 P53016 P90829 P91175 P91356 Q09645 Q10051 Q10578 Q17392 Q17684 Q18547 Q18841 Q18963 Q19196 Q19366 Q19537 Q19826 Q20716 Q21302 Q21554 Q21730 Q22139 Q22798 Q23088 Q23457 Q7JKC3 Q86D18 Q93338 Q93456 Q95PZ4 Q965S0 Q9GR61 Q9N390 Q9N3C9 Q9N3L2 Q9N5K2 Q9U1Q7 Q9U3I0 Q9XVH6	CELE_F53H4.6 CELE_R04F11.3 CELE_T26A5.8 F10C2.4 F12F6.7 F44B9.8 T24H10.1 ama-1 cdk-7 csa-1 cul-4 ddb-1 emb-4 ercc-1 gtf-2H1 gtf-2H2C gtf-2H3 gtf-2H4 gtf-2H5 gtf-2h1 gtf-2h3 isy-1 math-33 mnat-1 pcn-1 pole-1 pole-2 polk-1 prp-19 rbx-1 rfc-1 rfc-2 rfc-3 rfc-4 rpa-1 rpa-4 rpb-1 rpb-10 rpb-11 rpb-12 rpb-2 rpb-3 rpb-4 rpb-5 rpb-6 rpb-7 rpb-8 rpb-9 sel-13 syf-1 ubia ubib ubl-1 ubq-1 ubq-2 usp-7 uvs-1 xpa-1 xpb-1 xpd-1 xpf-1	Caenorhabditis elegans
Rap1 signalling	14-3-3-like protein 1 14-3-3-like protein 2 Raf homolog serine/threonine-protein kinase Rap guanine nucleotide exchange factor 1 Rap-GAP domain-containing protein Rap-GAP domain-containing protein Ras guanyl-releasing protein 3 Ras-related protein Rap-1 cAMP-dependent protein kinase catalytic subunit cGMP-dependent protein kinase egl-4	H2L055 H2L2C2 O76360 P21137 P34578 P41932 Q07292 Q18246 Q19770 Q20655	CELE_F53A10.2 cgk-1 egl-4 epac-1 ftt-1 ftt-2 kin-1 lin-45 odr-9 par-5 raf-1 rap-1 rgef-1 sipa-1	Caenorhabditis elegans
Thyroxine biosynthesis	Dual oxidase 1 Iodotyrosine dehalogenase 1 homolog NAD(P)H oxidase (H2O2-forming) Peroxidasin homolog pxn-1 Peroxidasin homolog pxn-2 Sodium-coupled monocarboxylate transporter 2 Sodium-dependent multivitamin transporter	G5EG78 O01795 O17394 O61213 P34273 Q1ENI8 Q23616	CELE_F52H2.4 bli-3 duox-2 pxn-1 pxn-2 slc-5A12 sup-18	Caenorhabditis elegans
Asparagine N-linked glycosylation	C-type lectin domain-containing protein 87 C-type lectin domain-containing protein 88 C-type lectin domain-containing protein 91 C-type lectin domain-containing protein C-type lectin domain-containing protein C-type lectin domain-containing protein C-type lectin domain-containing protein C-type lectin domain-containing protein C-type lectin domain-containing protein C-type lectin domain-containing protein C-type lectin domain-containing protein C-type lectin domain-containing protein C-type lectin domain-containing protein C-type lectin domain-containing protein C-type lectin domain-containing protein	D3KFV8 H2KZ07 O18076 O45275 P91214 Q18821 Q1ZXU1 Q20665 Q21146 Q86NG3 Q94417 Q9N4W5 Q9XVS3 Q9XVT9 Q9XX56	CELE_F52E1.2 CELE_Y38H6C.8 clec-149 clec-196 clec-199 clec-202 clec-204 clec-224 clec-266 clec-45 clec-47 clec-86 clec-87 clec-88 clec-91 cpg-5 cpg-6	Caenorhabditis elegans
PKR-mediated signaling	ATP-dependent RNA helicase A Cyclin-dependent kinase 1 DRBM domain-containing protein DRBM domain-containing protein DZF domain-containing protein DZF domain-containing protein Dual specificity mitogen-activated protein kinase kinase jkk-1 Dual specificity mitogen-activated protein kinase kinase mek-1 Dual specificity mitogen-activated protein kinase kinase sek-1 E3 ubiquitin-protein ligase ari-1.1 Eukaryotic translation initiation factor 2-alpha kinase pek-1 HECT domain-containing protein J domain-containing protein NCK (Non-Catalytic region of tyrosine Kinase) adaptor protein family Polyubiquitin-A Probable serine/threonine-protein phosphatase PP2A regulatory subunit Protein kinase domain-containing protein STE20-related kinase adapter protein strd-1 Serine/threonine-protein phosphatase 2A catalytic subunit Serine/threonine-protein phosphatase 2A regulatory subunit pptr-1 Signal transducer and activator of transcription 1 Signal transducer and activator of transcription b Sphingosine kinase 1 Ubiquitin-conjugating enzyme E2 ubc-18 Ubiquitin-like domain-containing protein X-linked retinitis pigmentosa GTPase regulator homolog mitogen-activated protein kinase kinase mitogen-activated protein kinase kinase mitogen-activated protein kinase kinase mitogen-activated protein kinase kinase	D3YT30 E9RKC7 G5EBF5 G5ECN5 G5EDF7 G5EDT6 G5EGK8 O01965 O18178 O44820 O62349 P0CG71 P34556 P91189 Q09543 Q18425 Q19192 Q20977 Q21307 Q21633 Q22307 Q58AU7 Q58AU8 Q5DX34 Q8MPS3 Q95PX0 Q9BL11 Q9NAD6 Q9TYV7 Q9XWJ9	CELE_F52C6.3 CELE_R11H6.5 CELE_T12G3.2 ari-1.1 cdk-1 dnj-7 dus-2 glo-4 herc-1 jkk-1 let-92 mek-1 mek-5 ncc-1 nck-1 paa-1 pek-1 pptr-1 rde-4 rha-1 sek-1 sek-3 sek-4 sek-5 sphk-1 sta-1 sta-2 stat-b strd-1 tag-274 ubc-18 ubia ubq-1 zfr-1	Caenorhabditis elegans
ISG15 antiviral mechanism	Beclin homolog Calponin-homology (CH) domain-containing protein E1 ubiquitin-activating enzyme E3 ubiquitin-protein ligase ari-1.1 E3 ubiquitin-protein ligase Eukaryotic initiation factor 4A Eukaryotic translation initiation factor 2-alpha kinase pek-1 Eukaryotic translation initiation factor 4E-1 Eukaryotic translation initiation factor 4E-2 Eukaryotic translation initiation factor 4E-3 Eukaryotic translation initiation factor 4E-4 Eukaryotic translation initiation factor 4E-5 HECT domain-containing protein Helicase ATP-binding domain-containing protein MIF4G domain-containing protein Mitogen-activated protein kinase mpk-1 Polyubiquitin-A Protein kinase domain-containing protein Protein phosphatase ppm-1.A RNA helicase RNA helicase Signal transducer and activator of transcription 1 Signal transducer and activator of transcription b TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 UBC core domain-containing protein Ubiquitin carboxyl-terminal hydrolase usp-48 Ubiquitin-conjugating enzyme E2 13 Ubiquitin-conjugating enzyme E2 ubc-18 Ubiquitin-like domain-containing protein X-linked retinitis pigmentosa GTPase regulator homolog	A0A061ACQ8 A0A486WX07 D3YT30 G5ECC7 G5EEM6 O01965 O44820 O45551 O61955 P0CG71 P27639 P39745 P56570 Q19192 Q19775 Q20617 Q20935 Q20977 Q21633 Q21693 Q22592 Q22888 Q27481 Q5DX34 Q93413 Q95XX0 Q9BL11 Q9BL61 Q9NAD6 U4PBJ9	CELE_F52C6.3 CELE_F57B9.3 CELE_T12G3.2 CELE_Y92H12A.2 ari-1.1 atg-6 bec-1 drh-3 eif-4A3 fln-1 glo-4 herc-1 ife-1 ife-2 ife-3 ife-4 ife-5 ifg-1 inf-1 mpk-1 pek-1 ppm-1.A sta-1 sta-2 stat-b sur-1 tap-1 uba-1 ubc-13 ubc-18 ubc-24 ubia ubq-1 usp-48	Caenorhabditis elegans

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