GlyCosmos Portal

GlyCosmos Pathways

Integrated of pathway data, containing glycoproteins and glycans obtained from Reactome and the Metabolism of carbohydrates in Escherichia coli O-antigens obtained from ECODAB. Search by pathway name, species, and protein name.

Source	Last Updated
Reactome	March 20, 2024
ECODAB	April 1, 2019

Displaying entries **101 - 125** of **252** in total

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Pathway Name	Protein Name	UniProt ID	Gene Symbol ▼	Organism	GlyTouCan ID
MDK and PTN in ALK signaling	ALK tyrosine kinase receptor Midkine Pleiotrophin	F8W3R9 Q502U6 Q9DDG2	alk cb518 fb79b05 fj33b02 fj48a12 mdk mdk2 mdkb plei2 ptn wu:fb79b05 wu:fj33b02 wu:fj48a12 zHBNF zgc:111787	Danio rerio (zebrafish)
Signaling by ALK	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma ALK and LTK ligand 1 ALK and LTK ligand 2b ALK tyrosine kinase receptor Midkine Phosphatidylinositol 3-kinase regulatory subunit alpha Phosphatidylinositol 3-kinase regulatory subunit beta Pleiotrophin phosphatidylinositol-4,5-bisphosphate 3-kinase phosphatidylinositol-4,5-bisphosphate 3-kinase	B0S6V7 B3DHG9 E7F251 E7FAP8 F1QAD7 F8W2C9 F8W3R9 Q502U6 Q804J6 Q9DDG2	alk alkal1 alkal2b cb518 fb79b05 fj33b02 fj46f04 fj48a12 mdk mdk2 mdkb pik3ca pik3cb pik3r1 pik3r2 plcg1 plei2 ptn wu:fb65b05 wu:fb79b05 wu:fj33b02 wu:fj46f04 wu:fj48a12 wu:fj57a05 zHBNF zgc:111787	Danio rerio (zebrafish)
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein	Alpha-1,3-glucosyltransferase Asparagine-linked glycosylation 1 homolog (Yeast, beta-1,4-mannosyltransferase) Dol-P-Man Mannose-P-dolichol utilization defect 1 protein homolog Mannosyltransferase UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase	A2BFS6 A5PLJ6 Q501Z4 Q566T2 Q6IQH2 Q7SXK9	alg1 alg12 alg3 alg8 dpagt1 fb18d03 mpdu1b si:ch211-117m20.1 si:dkey-164m14.3 si:rp71-1p14.2 wu:fb18d03 wu:fi19e09 wu:fi19f07 wu:fi34b12 zgc:112396 zgc:112507 zgc:66221 zgc:86765	Danio rerio (zebrafish)
Metabolism of folate and pterines	10-formyltetrahydrofolate dehydrogenase 5-formyltetrahydrofolate cyclo-ligase C-1-tetrahydrofolate synthase, cytoplasmic Folate receptor gamma precursor Folate transporter 1 Folylpolyglutamate synthase Mitochondrial folate transporter/carrier Proton-coupled folate transporter Serine hydroxymethyltransferase dihydrofolate reductase formate--tetrahydrofolate ligase glycine hydroxymethyltransferase methenyltetrahydrofolate cyclohydrolase methylenetetrahydrofolate reductase (NADPH)	A0A0G2L0J2 A5PLB2 A9LDD9 B0V153 E3NZ06 E7F2A7 F1Q7N0 F1QQ79 Q5CZP1 Q5RIH2 Q6GMK2 Q6IQS4 Q7SXN1 Q7ZWG6	aldh1l1 cb595 dhfr fa92h12 fk48e08 fk51d09 folr fpgs im:7144504 mthfd1a mthfd1l mthfd2 mthfr mthfs pcft shmt1 shmt2 si:dkey-25e12.5 si:dkey-25e12.6 si:dkeyp-100a1.4 slc19a1 slc25a32b slc46a1 wu:fa92h12 wu:fb38b11 wu:fe12e11 wu:fk48e08 wu:fk49h03 wu:fk51d09 zgc:110786 zgc:63807 zgc:66171 zgc:77524 zgc:86637 zgc:91891	Danio rerio (zebrafish)
G beta:gamma signalling through PI3Kgamma	3-phosphoinositide-dependent protein kinase 1 Rho-related GTP-binding protein RhoA-C non-specific serine/threonine protein kinase non-specific serine/threonine protein kinase	E7EXT6 Q6NZV1 Q7T2E8 Q8UUX0	akt2 akt3b cb945 pdpk1b rhoac zgc:77318	Danio rerio (zebrafish)
Negative regulation of the PI3K/AKT network	Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN Tribbles homolog 3 non-specific serine/threonine protein kinase non-specific serine/threonine protein kinase	E7EXT6 Q6NY44 Q7ZZ56 Q8UUX0	akt2 akt3b cb945 fa11a08 fb73f10 fc83f12 fd16b10 fk90e11 pten ptenb si:bz1g13.4 trib3 wu:fa11a08 wu:fb73f10 wu:fc83f12 wu:fd16b10 wu:fk90e11 zgc:76966	Danio rerio (zebrafish)
Fructose biosynthesis	Aldo-keto reductase family 1 member B1	Q1JPZ2	akr1b1.2 si:dkey-180p18.9 zgc:153855	Danio rerio (zebrafish)	G58161NS
Nicotinamide salvaging	ATP-dependent (S)-NAD(P)H-hydrate dehydratase Cytochrome P450, family 8, subfamily B, polypeptide 1 NAD(P)H-hydrate epimerase NAD-capped RNA hydrolase NUDT12 Nicotinamide N-methyltransferase Nicotinate phosphoribosyltransferase Poly [ADP-ribose] polymerase Poly [ADP-ribose] polymerase Poly [ADP-ribose] polymerase Prostacyclin synthase Prostaglandin G/H synthase 2 Renalase Sodium-coupled monocarboxylate transporter 1	F1Q575 F1QUL7 F1R1Q8 F1RE08 Q08CN1 Q3ZMH1 Q567I5 Q5RI06 Q6AZW0 Q6DHI7 Q6DHK1 Q6NX05 Q6P3H4	aibp apoa1bp cyp8b1.1 naprt naprt1 naxd naxe nudt12 parp16 parp6b parp8 ptgis ptgisl ptgs2b rnls si:ch73-198j8.4 si:dkey-3h3.2 si:dkey-97o5.6 slc5a8 slc5a8l smcte zgc:64002 zgc:77744 zgc:92286 zgc:92406	Danio rerio (zebrafish)
O-linked glycosylation	Beta-1,4-glucuronyltransferase 1 Dystroglycan 1 Protein O-linked-mannose beta-1,2-N-acetylglucosaminyltransferase Protein O-linked-mannose beta-1,4-N-acetylglucosaminyltransferase 2 Protein O-mannose kinase Protein O-mannosyl-transferase 1 Protein O-mannosyl-transferase 2 UDP-GalNAc Xylosyl- and glucuronyltransferase LARGE1 Xylosyl- and glucuronyltransferase LARGE2s	F1Q8R9 F1QF89 F1QMH7 F1QNB2 L7YAI7 Q502B3 Q5NDE5 Q5U3W1 Q66PG1 Q66PG2	ago61 b3galnt2 b3gnt1 b4gat1 dag dag1 gtdc2 gyltl1b im:7151461 large large1 large2 pomgnt1 pomgnt2 pomk pomt1 pomt2 sgk196 wu:fb83d06 wu:fi25f06 wu:fi37b08 zPOMGnT1 zgc:109786 zgc:158130	Danio rerio (zebrafish)
Glycerophospholipid biosynthesis	Acylglycerol kinase, mitochondrial Copine VII	E7F725 Q7ZW00	agk cpne7 mulk	Danio rerio (zebrafish)
Adrenaline signalling through Alpha-2 adrenergic receptor	Alpha-2A adrenergic receptor Alpha-2B adrenergic receptor Alpha-2C adrenergic receptor	Q90WY4 Q90WY5 Q90WY6	adra2a adra2b adra2c	Danio rerio (zebrafish)
G alpha (12/13) signalling events	Alpha-1B-adrenergic receptor FGD4 G-protein alpha 12 Gna13a protein PDZ-RhoGEF Ras-specific guanine nucleotide-releasing factor 2 Rho guanine nucleotide exchange factor (GEF) 37 Rho guanine nucleotide exchange factor (GEF) 39 Rho-associated protein kinase Rho-related GTP-binding protein RhoA-C Rho/rac guanine nucleotide exchange factor (GEF) 18 Son of sevenless homolog Thromboxane A2 receptor Triple functional domain protein	A2CEA7 A2RRV5 B0R089 D5FS19 E7F3M3 Q1LUA6 Q49U75 Q4VBH5 Q5U3D9 Q5YKG4 Q6NSP2 Q7T2E8 Q90Y37 T2HVK6	adra1bb arhgef11 arhgef18 arhgef18a arhgef37 arhgef39 fgd4 fgd4a fj59e07 gna12 gna12a gna12l gna13 gna13a rasgrf2 rhoac rock2 rock2a rok2 si:ch211-194i18.1 si:dkey-57m7.1 sos1 tbxa2r trio wu:fc21e04 wu:fe25e05 wu:fj05f11 wu:fj59e07 zgc:103517 zgc:103685 zgc:112436 zgc:158274 zgc:85686	Danio rerio (zebrafish)
Adrenoceptors	Alpha-1B-adrenergic receptor Alpha-2A adrenergic receptor Alpha-2B adrenergic receptor Alpha-2C adrenergic receptor Beta-1 adrenergic receptor Beta-2 adrenergic receptor	A4QNV7 B3DHM6 Q5U3D9 Q90WY4 Q90WY5 Q90WY6	adra1bb adra2a adra2b adra2c adrb1 adrb2b zgc:103685 zgc:162188 zgc:194728 zgc:194731	Danio rerio (zebrafish)
Calcitonin-like ligand receptors	Adm2 protein Calcitonin gene-related peptide 2 isoform X1 Calcitonin gene-related peptide type 1 receptor Ramp2 protein Receptor activity-modifying protein 1	A9JR59 B3DJI5 F1QIK6 Q68EK2 Q6DGA3	adm2 adm2a calc calca calcrl calcrla cgrp imdn ramp1 ramp2 si:dkey-22l11.3 zgc:174936 zgc:92886	Danio rerio (zebrafish)
EGR2 and SOX10-mediated initiation of Schwann cell myelination	Adhesion G-protein coupled receptor G6	C6KFA3	adgrg6 gpr126	Danio rerio (zebrafish)
Antagonism of Activin by Follistatin	Follistatin-A Follistatin-like 3 (secreted glycoprotein) Inhibin beta A chain Inhibin beta B chain	A1L1T8 A4IG14 B0S7E0 Q9YHV4	actbb actbetaB fst fst1 fsta fstl3 inhbab inhbal inhbb si:dkey-28h18.3 zgc:114170 zgc:158348	Danio rerio (zebrafish)
RHO GTPases Activate Formins	Actin, cytoplasmic 1 Actin, cytoplasmic 2 Disheveled-associated activator of morphogenesis 1 Dishevelled, dsh homolog 2 (Drosophila) Formin-like 1a Profilin Profilin Profilin Ras-related C3 botulinum toxin substrate 1 Rho-related GTP-binding protein RhoA-C SLIT-ROBO Rho GTPase-activating protein 2	B0S6J3 E7F0A1 I3ITQ8 Q5RHJ3 Q6AZA1 Q7T2E8 Q7ZSZ9 Q7ZVF9 Q7ZVI7 Q802D5 Q803Q5	actba actbb bact bactin1 bactin2 bactzf daam1b daam1l dvl2 fa91a03 fc83b10 fmnl1a hm:zeh0341 pfn1 pfn2 pfn2a pfn2b pfn2l rac1 rac1a rhoac sb:cb813 sb:eu471 si:ch211-87i20.1 srgap2 wu:fa91a03 wu:fb01g08 wu:fb02e10 wu:fb54f09 wu:fc05d12 wu:fc83b10 wu:fd16e02 wu:fd58f06 wu:fi35b08 wu:fo71e09 wu:fp54a02 zgc:55372 zgc:55823 zgc:55917 zgc:86790 zgc:86934	Danio rerio (zebrafish)
Stimuli-sensing channels	Acid-sensing ion channel 1A Acid-sensing ion channel 1B Acid-sensing ion channel 1C Acid-sensing ion channel 2 Acid-sensing ion channel 4-A Anoctamin-10 Chloride channel 2c Chloride channel protein Protein tweety homolog 2-like Protein tweety homolog 3 Stomatin (EPB72)-like 3a Two pore channel protein 2 Uncharacterized protein LOC550523	A0JMD4 A5PLE0 E7FCE2 Q08BG8 Q32LT7 Q4V8U5 Q568N1 Q6NUZ2 Q708S4 Q708S5 Q708S6 Q708S7 Q708S8	accn1 accn2a accn2b accn2c accn4a ano10 asic1a asic1b asic1c asic2 asic4a clcn2c clcn4 im:6903943 si:ch211-229n1.3 stoml3 stoml3a stoml3b tmem16k tpc2 tpcn2 ttyh2l ttyh3b zgc:110200	Danio rerio (zebrafish)
Hyaluronan biosynthesis and export	ATP-binding cassette sub-family C member 5	E1B2R7	abcc5 fj51h02 si:ch1073-183g13.2 wu:fj51h02	Danio rerio (zebrafish)	G35674CY
Neurotransmitter receptors and postsynaptic signal transmission	Glycine receptor betaZ subunit (Fragment) Glycine receptor subunit alpha-2 Glycine receptor subunit alphaZ1	F1R8P4 O93430 Q9DES8	[b]Z fj42f03 glra1 glra2 glrb glrb1 glrba glyR beta wu:fj42f03	Danio rerio (zebrafish)
WNT ligand biogenesis and trafficking	Protein Wnt-10a Protein Wnt-10b Protein Wnt-1 Protein Wnt-2 Protein Wnt-4a Protein Wnt-5b Protein Wnt-8a Protein Wnt-8b Protein Wnt Protein Wnt Protein Wnt Protein Wnt Protein Wnt Protein Wnt Protein Wnt Transmembrane emp24 domain-containing protein 5	A1BPR0 B0LK22 B6V3E1 B6V3E2 P24257 P43446 P47793 P51028 P51029 Q1L130 Q4JLT0 Q6IYD9 Q7T2E9 Q801F7 Q92048 Q92050	Zwnt[a] cgi100 cgi1000 int-1 tmed5 wnt-1 wnt-10a wnt-2 wnt-4 wnt-5 wnt-8 wnt-8b wnt1 wnt10a wnt10b wnt2 wnt2bb wnt3 wnt3 l wnt3a wnt3l wnt4 wnt4a wnt5 wnt5a wnt5b wnt7a wnt7aa wnt8 wnt8a wnt8b wnt9a wnt9b wnt[a] zgc:153617 zgc:63936	Danio rerio (zebrafish)
Transport of bile salts and organic acids, metal ions and amine compounds	Choline transporter-like protein 2 Choline transporter-like protein 4 Facilitated urea transporter Multidrug and toxin extrusion protein 1 Multidrug and toxin extrusion protein	A1L1P9 Q533H0 Q7SYC9 Q7T2B0 U3PTD6	UT ctl2 ctl4 fe01a06 mate1 mate7 si:dkey-175a17.4 slc14a2 slc44a2 slc44a4 slc47a1 slc47a4 wu:fe01a06	Danio rerio (zebrafish)
Trafficking and processing of endosomal TLR	Protein unc-93 homolog B1 Transforming growth factor beta activator LRRC33	F1QYA8 Q6AXL3	UNC93B1 lrrc33 nrros unc93b1	Danio rerio (zebrafish)
Detoxification of Reactive Oxygen Species	Bis(5'-nucleosyl)-tetraphosphatase [asymmetrical] Catalase Cytochrome b-245 heavy chain Cytochrome b-245 light chain Cytochrome c ERO1-like protein alpha Extracellular superoxide dismutase [Cu-Zn] Glutathione S-transferase Glutathione peroxidase Glutathione peroxidase Neutrophil cytosol factor 1 Neutrophil cytosol factor 2 Peroxiredoxin-2 Peroxiredoxin-5 Peroxiredoxin-6 Probable glutathione peroxidase 8 Protein disulfide-isomerase Superoxide dismutase [Cu-Zn] Superoxide dismutase Thioredoxin 2 Thioredoxin-dependent peroxide reductase, mitochondrial Thioredoxin Thioredoxin thioredoxin-dependent peroxiredoxin	A0A0R4IPV5 A2AWE1 A2VCY2 A5PLA4 F1QTD7 O73872 Q4Z8P3 Q502C8 Q502E1 Q5BJB9 Q6DG97 Q6DGI6 Q6DGJ6 Q6IQM2 Q6P131 Q6P980 Q6PBK9 Q6PH62 Q7T2A7 Q7T3D1 Q7ZUI4 Q7ZV14 Q9DDU5 Q9PT92	TXN cat cb356 cb463 cb58 cb718 cb893 cuzn cyba cybb cyc ero1a ero1l fa02f07 fb15h09 gpx7 gpx8 gpx9 gstp1 gstp1.2 hm:zehl0637 im:6902827 im:7151832 ncf1 ncf2 nudt2 p4hb prdx1 prdx2 prdx3 prdx5 prdx6 psmb3 si:ch73-111m19.2 sod1 sod2 sod3a txn txn2 wu:fa02f07 wu:fb15h09 wu:fj23a02 wu:fj33b01 wu:fk49e09 wu:fq19b09 zgc:103706 zgc:110282 zgc:110343 zgc:112293 zgc:112318 zgc:112512 zgc:158405 zgc:64144 zgc:66077 zgc:73051 zgc:73360 zgc:77127 zgc:91915 zgc:92596 zgc:92891 zgc:92903	Danio rerio (zebrafish)
The NLRP3 inflammasome	Apoptosis-associated speck-like protein containing a CARD Heat shock protein HSP 90-beta NACHT, LRR and PYD domains-containing protein 1 homolog P2X purinoceptor Pannexin-1 Proline-serine-threonine phosphatase-interacting protein 1 Protein SGT1 homolog Thioredoxin-interacting protein Thioredoxin Thioredoxin Uncharacterized protein LOC568410	A0A386CAB9 B3DJF9 O57521 Q2YDR2 Q5U3E4 Q6DGI6 Q7SZM2 Q7ZUI4 Q7ZUN0 Q7ZWB6 Q9I9N6	TXN asc asc1 fb15h09 hsp90ab1 hsp90b hspc3 nlrp1 p2rx7 p2xr7 panx1 panx1a pstpip1b pycard sb:cb368 sgut1 sugt1 txn txnip txnipa wu:fb15h09 wu:fd45a02 zgc:123255 zgc:194990 zgc:55631 zgc:92903	Danio rerio (zebrafish)

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