GlyCosmos Portal

GlyCosmos Pathways

Integrated of pathway data, containing glycoproteins and glycans obtained from Reactome and the Metabolism of carbohydrates in Escherichia coli O-antigens obtained from ECODAB. Search by pathway name, species, and protein name.

Source	Last Updated
Reactome	March 20, 2024
ECODAB	April 1, 2019

Displaying entries **26 - 50** of **128** in total

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Pathway Name	Protein Name	UniProt ID ▲	Gene Symbol	Organism	GlyTouCan ID
Detoxification of Reactive Oxygen Species	1-Cys peroxiredoxin Catalase-A Cytochrome c Extracellular superoxide dismutase [Cu-Zn] 2 Extracellular superoxide dismutase [Cu-Zn] 3 Glutathione S-transferase domain-containing protein DDB_G0273153/DDB_G0273923 Glutathione reductase Peroxiredoxin-4 Probable copper chaperone for superoxide dismutase Probable superoxide dismutase [Cu-Zn] 6 Putative glutathione S-transferase alpha-1 Putative glutathione S-transferase alpha-2 Putative glutathione S-transferase alpha-3 Putative glutathione S-transferase alpha-4 Putative glutathione S-transferase alpha-5 Putative thioredoxin-4 Superoxide dismutase [Cu-Zn] 4 Superoxide dismutase [Cu-Zn] 5 Superoxide dismutase [Mn], mitochondrial Superoxide-generating NADPH oxidase heavy chain subunit A Superoxide-generating NADPH oxidase heavy chain subunit B Superoxide-generating NADPH oxidase heavy chain subunit C Thioredoxin domain-containing protein Thioredoxin domain-containing protein Thioredoxin-3	O77229 P29447 Q1ZXE0 Q54F44 Q54F73 Q54G70 Q54N76 Q54NX3 Q54QV7 Q54RN1 Q54RQ1 Q54SE2 Q54TU5 Q54TW8 Q54VI4 Q555L5 Q556G3 Q556P3 Q55BJ9 Q55FF3 Q869N1 Q86AU1 Q86GL4 Q8T137 Q9XYS3	DDB_G0273153 DDB_G0282517 DDB_G0284939 cat catA ccs ccsA cytC gsr gsta1 gsta2-1 gsta2-2 gsta3 gsta4 gsta5 noxA noxB noxC prdx4 prdx5 sod2 sodB sodC sodD sodE sodF trx3 trx4 trxC trxD	Dictyostelium discoideum
Orc1 removal from chromatin	26S proteasome non-ATPase regulatory subunit 10 26S proteasome non-ATPase regulatory subunit 11 26S proteasome non-ATPase regulatory subunit 12 26S proteasome non-ATPase regulatory subunit 13 26S proteasome non-ATPase regulatory subunit 14 26S proteasome non-ATPase regulatory subunit 1 26S proteasome non-ATPase regulatory subunit 2 26S proteasome non-ATPase regulatory subunit 3 26S proteasome non-ATPase regulatory subunit 4 26S proteasome non-ATPase regulatory subunit 6 26S proteasome non-ATPase regulatory subunit 7 26S proteasome regulatory subunit 10B 26S proteasome regulatory subunit 4 homolog 26S proteasome regulatory subunit 6A homolog 26S proteasome regulatory subunit 6B homolog 26S proteasome regulatory subunit 7 Cullin-2 Origin recognition complex subunit 1 Polyubiquitin-F Polyubiquitin-G Polyubiquitin-H Polyubiquitin-I Polyubiquitin-J Probable 26S proteasome non-ATPase regulatory subunit 8 Probable 26S proteasome non-ATPase regulatory subunit 9 Proteasome activator 28 Proteasome activator complex subunit 4 Proteasome inhibitor PI31 subunit Proteasome subunit alpha type-1 Proteasome subunit alpha type-2 Proteasome subunit alpha type-3 Proteasome subunit alpha type-4 Proteasome subunit alpha type-5 Proteasome subunit alpha type-6 Proteasome subunit alpha type-7 Proteasome subunit beta type-2 Proteasome subunit beta type-3 Proteasome subunit beta type-4 Proteasome subunit beta type-5 Proteasome subunit beta type-6 Proteasome subunit beta type-7 RING-box protein 1 SCF ubiquitin ligase complex protein SKP1a SCF ubiquitin ligase complex protein SKP1b Ubiquitin-like domain-containing protein Ubiquitin-ribosomal protein eL40 fusion protein Ubiquitin-ribosomal protein eS31 fusion protein Uncharacterized protein	P02889 P0CG78 P0CG79 P0CG80 P0CG81 P0CG88 P14794 P14797 P34119 P34120 P34123 P52285 Q1ZXD3 Q27562 Q27563 Q54BC6 Q54BC8 Q54CI0 Q54DB2 Q54DM7 Q54HW1 Q54JM5 Q54K33 Q54NQ0 Q54PJ1 Q54PN7 Q54QR2 Q54RM2 Q54S82 Q54UB5 Q54UJ0 Q54WI8 Q54XM7 Q552Y8 Q553E0 Q556Q0 Q557E4 Q559F4 Q55BV5 Q55C75 Q55D66 Q55DY7 Q55G04 Q55GJ6 Q86IJ1 Q86JA1 Q967U1 Q9XZJ3	DDB_G0272951 M4 cul2 culB dapA dpr1 fp21A fp21B fpa1 fpa1A fpa1B fpa2 fpaA fpaB-1 fpaB-2 orc1 orcA prdD prdE prtC prtD psmA1 psmA2 psmA3 psmA4 psmA5 psmA6 psmA7 psmB2 psmB3 psmB4-1 psmB4-2 psmB5 psmB6 psmB7 psmC1 psmC2 psmC3 psmC4 psmC6 psmD1 psmD10 psmD11 psmD12 psmD13 psmD14 psmD2 psmD3 psmD4 psmD6 psmD7 psmD8-1 psmD8-2 psmD9 psmE3 psmE4 psmF1 rbx1 skp1A skp1B sks1 tbp2 tbpB ubqB ubqC ubqF ubqG ubqH ubqI ubqJ ubqO veg116	Dictyostelium discoideum
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis	26S proteasome non-ATPase regulatory subunit 10 26S proteasome non-ATPase regulatory subunit 11 26S proteasome non-ATPase regulatory subunit 12 26S proteasome non-ATPase regulatory subunit 13 26S proteasome non-ATPase regulatory subunit 14 26S proteasome non-ATPase regulatory subunit 1 26S proteasome non-ATPase regulatory subunit 2 26S proteasome non-ATPase regulatory subunit 3 26S proteasome non-ATPase regulatory subunit 4 26S proteasome non-ATPase regulatory subunit 6 26S proteasome non-ATPase regulatory subunit 7 26S proteasome regulatory subunit 10B 26S proteasome regulatory subunit 4 homolog 26S proteasome regulatory subunit 6A homolog 26S proteasome regulatory subunit 6B homolog 26S proteasome regulatory subunit 7 Aurora kinase Cullin-2 Polyubiquitin-F Polyubiquitin-G Polyubiquitin-H Polyubiquitin-I Polyubiquitin-J Probable 26S proteasome non-ATPase regulatory subunit 8 Probable 26S proteasome non-ATPase regulatory subunit 9 Proteasome activator 28 Proteasome activator complex subunit 4 Proteasome inhibitor PI31 subunit Proteasome subunit alpha type-1 Proteasome subunit alpha type-2 Proteasome subunit alpha type-3 Proteasome subunit alpha type-4 Proteasome subunit alpha type-5 Proteasome subunit alpha type-6 Proteasome subunit alpha type-7 Proteasome subunit beta type-2 Proteasome subunit beta type-3 Proteasome subunit beta type-4 Proteasome subunit beta type-5 Proteasome subunit beta type-6 Proteasome subunit beta type-7 RING-box protein 1 SCF ubiquitin ligase complex protein SKP1a SCF ubiquitin ligase complex protein SKP1b Ubiquitin-like domain-containing protein Ubiquitin-ribosomal protein eL40 fusion protein Ubiquitin-ribosomal protein eS31 fusion protein Uncharacterized protein	P02889 P0CG78 P0CG79 P0CG80 P0CG81 P0CG88 P14794 P14797 P34119 P34120 P34123 P52285 Q1ZXD3 Q27562 Q27563 Q54BC6 Q54BC8 Q54CI0 Q54DB2 Q54DM7 Q54HW1 Q54JM5 Q54K33 Q54NQ0 Q54PJ1 Q54PN7 Q54QR2 Q54S82 Q54UB5 Q54UJ0 Q54WI8 Q54WX4 Q54XM7 Q552Y8 Q553E0 Q556Q0 Q557E4 Q559F4 Q55BV5 Q55C75 Q55D66 Q55DY7 Q55G04 Q55GJ6 Q86IJ1 Q86JA1 Q967U1 Q9XZJ3	AurB Aurora DDB_G0272951 M4 aurK cul2 culB dapA dpr1 fp21A fp21B fpa1 fpa1A fpa1B fpa2 fpaA fpaB-1 fpaB-2 prdD prdE prtC prtD psmA1 psmA2 psmA3 psmA4 psmA5 psmA6 psmA7 psmB2 psmB3 psmB4-1 psmB4-2 psmB5 psmB6 psmB7 psmC1 psmC2 psmC3 psmC4 psmC6 psmD1 psmD10 psmD11 psmD12 psmD13 psmD14 psmD2 psmD3 psmD4 psmD6 psmD7 psmD8-1 psmD8-2 psmD9 psmE3 psmE4 psmF1 rbx1 skp1A skp1B sks1 tbp2 tbpB ubqB ubqC ubqF ubqG ubqH ubqI ubqJ ubqO veg116	Dictyostelium discoideum
ABC-family proteins mediated transport	26S proteasome non-ATPase regulatory subunit 10 26S proteasome non-ATPase regulatory subunit 11 26S proteasome non-ATPase regulatory subunit 12 26S proteasome non-ATPase regulatory subunit 13 26S proteasome non-ATPase regulatory subunit 14 26S proteasome non-ATPase regulatory subunit 1 26S proteasome non-ATPase regulatory subunit 2 26S proteasome non-ATPase regulatory subunit 3 26S proteasome non-ATPase regulatory subunit 4 26S proteasome non-ATPase regulatory subunit 6 26S proteasome non-ATPase regulatory subunit 7 26S proteasome regulatory subunit 10B 26S proteasome regulatory subunit 4 homolog 26S proteasome regulatory subunit 6A homolog 26S proteasome regulatory subunit 6B homolog 26S proteasome regulatory subunit 7 ABC transporter A family member 2 ABC transporter A family member 3 ABC transporter A family member 4 ABC transporter A family member 5 ABC transporter A family member 6 ABC transporter B family member 2 ABC transporter B family member 3 ABC transporter B family member 6 ABC transporter B family member 7 ABC transporter C family member 10 ABC transporter C family member 12 ABC transporter C family member 13 ABC transporter C family member 14 ABC transporter C family member 15 ABC transporter C family member 1 ABC transporter C family member 2 ABC transporter C family member 3 ABC transporter C family member 5 ABC transporter C family member 6 ABC transporter C family member 7 ABC transporter C family member 8 ABC transporter C family member 9 ABC transporter F family member 4 Eukaryotic translation initiation factor 2 subunit 1 Eukaryotic translation initiation factor 2 subunit 2 Eukaryotic translation initiation factor 2 subunit 3 Polyubiquitin-F Polyubiquitin-G Polyubiquitin-H Polyubiquitin-I Polyubiquitin-J Probable 26S proteasome non-ATPase regulatory subunit 8 Probable 26S proteasome non-ATPase regulatory subunit 9 Proteasome activator 28 Proteasome activator complex subunit 4 Proteasome inhibitor PI31 subunit Proteasome subunit alpha type-1 Proteasome subunit alpha type-2 Proteasome subunit alpha type-3 Proteasome subunit alpha type-4 Proteasome subunit alpha type-5 Proteasome subunit alpha type-6 Proteasome subunit alpha type-7 Proteasome subunit beta type-2 Proteasome subunit beta type-3 Proteasome subunit beta type-4 Proteasome subunit beta type-5 Proteasome subunit beta type-6 Proteasome subunit beta type-7 Serine protease/ABC transporter B family protein tagA Serine protease/ABC transporter B family protein tagB Serine protease/ABC transporter B family protein tagC Serine protease/ABC transporter B family protein tagD Ubiquitin-like domain-containing protein Ubiquitin-ribosomal protein eL40 fusion protein Ubiquitin-ribosomal protein eS31 fusion protein Uncharacterized protein	P02889 P0CG78 P0CG79 P0CG80 P0CG81 P0CG88 P14794 P14797 P34119 P34120 P34123 P54683 Q1ZXD3 Q23868 Q27562 Q27563 Q54BC6 Q54BC8 Q54BT3 Q54BT5 Q54CI0 Q54DB2 Q54DM7 Q54EK2 Q54HW1 Q54JM5 Q54JR2 Q54K24 Q54LE6 Q54NL1 Q54NQ0 Q54P13 Q54PJ1 Q54PN7 Q54QR2 Q54RU1 Q54S82 Q54T27 Q54U44 Q54UB5 Q54UJ0 Q54V86 Q54VC1 Q54VJ0 Q54WI8 Q54XD8 Q54XM7 Q552Y8 Q553E0 Q555Z5 Q556Q0 Q559F4 Q55BV5 Q55C75 Q55D66 Q55DA7 Q55DY7 Q55G04 Q55GJ6 Q869N9 Q86IJ1 Q86JA1 Q8ST87 Q8T6B4 Q8T6H3 Q8T6H8 Q8T6J1 Q8T6J2 Q8T6J5 Q8T9W1 Q8T9W4 Q967U1 Q9GTN7	DDB_G0272951 M4 abcA2 abcA3 abcA4 abcA5 abcA6 abcB2 abcB3 abcB6 abcB7 abcC1 abcC10 abcC12 abcC13 abcC14 abcC15 abcC2 abcC3 abcC5 abcC6 abcC7 abcC8 abcC9 abcF4 dapA dpr1 eif2G eif2a eif2b eif2s1 eif2s2 eif2s3 prdD prdE prtC prtD psmA1 psmA2 psmA3 psmA4 psmA5 psmA6 psmA7 psmB2 psmB3 psmB4-1 psmB4-2 psmB5 psmB6 psmB7 psmC1 psmC2 psmC3 psmC4 psmC6 psmD1 psmD10 psmD11 psmD12 psmD13 psmD14 psmD2 psmD3 psmD4 psmD6 psmD7 psmD8-1 psmD8-2 psmD9 psmE3 psmE4 psmF1 sks1 tagA tagB tagC tagD tbp2 tbpB ubqB ubqC ubqF ubqG ubqH ubqI ubqJ ubqO veg116	Dictyostelium discoideum
KEAP1-NFE2L2 pathway	26S proteasome non-ATPase regulatory subunit 10 26S proteasome non-ATPase regulatory subunit 11 26S proteasome non-ATPase regulatory subunit 12 26S proteasome non-ATPase regulatory subunit 13 26S proteasome non-ATPase regulatory subunit 14 26S proteasome non-ATPase regulatory subunit 1 26S proteasome non-ATPase regulatory subunit 2 26S proteasome non-ATPase regulatory subunit 3 26S proteasome non-ATPase regulatory subunit 4 26S proteasome non-ATPase regulatory subunit 6 26S proteasome non-ATPase regulatory subunit 7 26S proteasome regulatory subunit 10B 26S proteasome regulatory subunit 4 homolog 26S proteasome regulatory subunit 6A homolog 26S proteasome regulatory subunit 6B homolog 26S proteasome regulatory subunit 7 Autophagy-related protein 8-like protein DDB_G0290491 Autophagy-related protein 8 Cell division cycle protein 48 Cullin-3 Nuclear protein localization protein 4 homolog Polyubiquitin-F Polyubiquitin-G Polyubiquitin-H Polyubiquitin-I Polyubiquitin-J Probable 26S proteasome non-ATPase regulatory subunit 8 Probable 26S proteasome non-ATPase regulatory subunit 9 Proteasome activator 28 Proteasome activator complex subunit 4 Proteasome inhibitor PI31 subunit Proteasome subunit alpha type-1 Proteasome subunit alpha type-2 Proteasome subunit alpha type-3 Proteasome subunit alpha type-4 Proteasome subunit alpha type-5 Proteasome subunit alpha type-6 Proteasome subunit alpha type-7 Proteasome subunit beta type-2 Proteasome subunit beta type-3 Proteasome subunit beta type-4 Proteasome subunit beta type-5 Proteasome subunit beta type-6 Proteasome subunit beta type-7 RING finger domain and kelch repeat-containing protein DDB_G0271372 RING-box protein 1 Sestrin homolog UBX domain-containing protein 7 homolog Ubiquitin fusion degradation protein 1 homolog Ubiquitin-like domain-containing protein Ubiquitin-ribosomal protein eL40 fusion protein Ubiquitin-ribosomal protein eS31 fusion protein Uncharacterized protein ZZ-type zinc finger-containing protein	P02889 P0CG78 P0CG79 P0CG80 P0CG81 P0CG88 P14794 P14797 P34119 P34120 P34123 P90532 Q1ZXD3 Q27562 Q27563 Q54BC6 Q54BC8 Q54CI0 Q54DB2 Q54DM7 Q54G11 Q54GD3 Q54HW1 Q54JM5 Q54K33 Q54NQ0 Q54NZ5 Q54PJ1 Q54PN7 Q54QR2 Q54S82 Q54UB5 Q54UJ0 Q54WI8 Q54WU6 Q54XM7 Q552Y8 Q553E0 Q556Q0 Q559F4 Q55BF8 Q55BK0 Q55BU7 Q55BV5 Q55C75 Q55CE3 Q55D66 Q55DY7 Q55G04 Q55GJ6 Q86CR8 Q86IJ1 Q86JA1 Q967U1	DDB_G0270098 DDB_G0271372 DDB_G0272951 DDB_G0279427 DDB_G0290491 M4 apg8 atg8 cdcD cul3 culC dapA dpr1 npl4 nploc4 prdD prdE prtC prtD psmA1 psmA2 psmA3 psmA4 psmA5 psmA6 psmA7 psmB2 psmB3 psmB4-1 psmB4-2 psmB5 psmB6 psmB7 psmC1 psmC2 psmC3 psmC4 psmC6 psmD1 psmD10 psmD11 psmD12 psmD13 psmD14 psmD2 psmD3 psmD4 psmD6 psmD7 psmD8-1 psmD8-2 psmD9 psmE3 psmE4 psmF1 rbx1 sks1 tbp2 tbpB ubqB ubqC ubqF ubqG ubqH ubqI ubqJ ubqO ubxd7 ufd1 veg116	Dictyostelium discoideum
Degradation of the extracellular matrix	Counting factor associated protein D Cysteine proteinase 2 Cysteine proteinase 3 Cysteine proteinase 4 Cysteine proteinase 5 Cysteine proteinase 6 Cysteine proteinase 7 Uncharacterized protein Uncharacterized protein Uncharacterized protein	P04989 P54639 P54640 Q23894 Q54RQ2 Q54TR1 Q54Y60 Q7KWP5 Q94503 Q94504	CP2 CP3 CP4 CP5 CP6 CP7 DDB_G0272742 DDB_G0278401 DDB_G0282991 cfaD cprB cprC cprD cprE cprF cprG	Dictyostelium discoideum
Regulation of necroptotic cell death	Dual specificity protein kinase splA Dual specificity protein kinase splB Dual specificity protein kinase zak2 Dual specificity protein kinase zakA Polyubiquitin-F Polyubiquitin-G Polyubiquitin-H Polyubiquitin-I Polyubiquitin-J Probable E3 ubiquitin-protein ligase rbrA Probable serine/threonine-protein kinase DDB_G0267514 Probable serine/threonine-protein kinase DDB_G0272254 Probable serine/threonine-protein kinase DDB_G0288147 Probable serine/threonine-protein kinase drkA Probable serine/threonine-protein kinase drkB Probable serine/threonine-protein kinase drkC Probable serine/threonine-protein kinase qkgA Probable serine/threonine-protein kinase roco11 Probable serine/threonine-protein kinase roco4 Probable serine/threonine-protein kinase roco5 Probable serine/threonine-protein kinase roco7 Probable serine/threonine-protein kinase roco8 RBR-type E3 ubiquitin transferase RBR-type E3 ubiquitin transferase RBR-type E3 ubiquitin transferase RBR-type E3 ubiquitin transferase Seven transmembrane domain-containing tyrosine-protein kinase 1 UBC core domain-containing protein Ubiquitin-like domain-containing protein Ubiquitin-ribosomal protein eL40 fusion protein Ubiquitin-ribosomal protein eS31 fusion protein	P0CG78 P0CG79 P0CG80 P0CG81 P0CG88 P14794 P14797 P18160 P18161 Q1ZXD6 Q54CI0 Q54H45 Q54H46 Q54I29 Q54IL3 Q54JC7 Q54M77 Q54N73 Q54TA1 Q54XG4 Q54YU7 Q552C6 Q55A09 Q55GE6 Q55GU0 Q6T486 Q6XHA5 Q6XHB2 Q75JK0 Q8SSS9 Q8T2Q2	7tmk1 DDB_G0267514 DDB_G0272254 DDB_G0275145 DDB_G0278075 DDB_G0278981 DDB_G0288147 DDB_G0288683 DDB_G0289043 DpyK1 DpyK2 DpyK4 drkA drkB drkC pyK1 pyk2 pyk4 pykA pykB qkgA-1 qkgA-2 rbrA rk1 rk2 rk3 roco11 roco2-1 roco2-2 roco4 roco5 roco7 roco8 splA splB ubqB ubqC ubqF ubqG ubqH ubqI ubqJ ubqO veg116 vsk1 zak1 zak2 zakA	Dictyostelium discoideum
Iron uptake and transport	ABC transporter G family member 12 ABC transporter G family member 22 ABC transporter G family member 24 ABC transporter G family member 4 ABC transporter G family member 7 ABC transporter G family member 8 Cullin-2 Cullin-associated NEDD8-dissociated protein 1 Metal transporter nramp1 homolog NEDD8 Polyubiquitin-F Polyubiquitin-G Polyubiquitin-H Polyubiquitin-I Polyubiquitin-J Probable cytoplasmic aconitate hydratase SCF ubiquitin ligase complex protein SKP1a SCF ubiquitin ligase complex protein SKP1b Ubiquitin-like domain-containing protein Ubiquitin-ribosomal protein eL40 fusion protein Ubiquitin-ribosomal protein eS31 fusion protein	P0CG78 P0CG79 P0CG80 P0CG81 P0CG88 P14794 P14797 P52285 Q54CI0 Q54T02 Q54X73 Q54XV3 Q557E4 Q55DA0 Q869V1 Q86HQ2 Q86KD1 Q8T685 Q8T686 Q8T689 Q9XZJ3	abcG12 abcG22 abcG24 abcG4 abcG7 abcG8 acnA aco1 cand1 cul2 culB fp21A fp21B fpa1 fpa1A fpa1B fpa2 fpaA fpaB-1 fpaB-2 nedd8 nramp nramp1 skp1A skp1B slc11a1 ubqB ubqC ubqF ubqG ubqH ubqI ubqJ ubqO veg116	Dictyostelium discoideum
N-glycan trimming in the ER and Calnexin/Calreticulin cycle	Polyubiquitin-F Polyubiquitin-G Polyubiquitin-H Polyubiquitin-I Polyubiquitin-J Ubiquitin-like domain-containing protein Ubiquitin-ribosomal protein eL40 fusion protein Ubiquitin-ribosomal protein eS31 fusion protein mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase	P0CG78 P0CG79 P0CG80 P0CG81 P0CG88 P14794 P14797 Q54CI0 Q55G89	DDB_G0268520 ubqB ubqC ubqF ubqG ubqH ubqI ubqJ ubqO veg116	Dictyostelium discoideum	G03934XO G25577BM G28233ME G51034LA G86419OL
Reactions specific to the complex N-glycan synthesis pathway	Alpha-L-fucosidase Fucosyltransferase Fucosyltransferase Fucosyltransferase Fucosyltransferase Fucosyltransferase Fucosyltransferase Fucosyltransferase Fucosyltransferase Fucosyltransferase Fucosyltransferase alpha-L-fucosidase	P10901 Q54BB7 Q54L56 Q54P60 Q54PH9 Q54PJ9 Q54PK0 Q54PK3 Q54RA6 Q551C1 Q55FA8 Q86J24	DDB_G0276661 alfA fut1 fut10 fut11 fut2 fut3 fut4 fut5 fut6 fut7 fut9	Dictyostelium discoideum	G82576YO
Glycosphingolipid catabolism	Alpha-galactosidase Beta-galactosidase 1 Beta-hexosaminidase subunit A1 Beta-hexosaminidase subunit A2 Beta-hexosaminidase subunit B1 Beta-hexosaminidase subunit B2 Glucosylceramidase Neutral ceramidase A Probable alpha-galactosidase Saposin A Sphingomyelin phosphodiesterase A Sphingomyelin phosphodiesterase B Sphingomyelinase DDB_G0288017 Type I phosphodiesterase/nucleotide pyrophosphatase family protein Uncharacterized protein DDB_G0272682 beta-N-acetylhexosaminidase	P13723 Q1ZXD9 Q54BK2 Q54C16 Q54D71 Q54EG4 Q54GE1 Q54K55 Q54K56 Q54MJ8 Q54MU9 Q54Q68 Q54SC9 Q55B10 Q55C09 Q86IG2	DDB_G0272682 DDB_G0285897 DDB_G0288017 DDB_G0291524 DDB_G0292446 dcd dcd2A glb1 hexa1 hexa2 hexb1 hexb2 melA nagA nagE rsc25 sapA sgmA sgmB	Dictyostelium discoideum	G09546QO G27025MB G58161NS
Keratan sulfate degradation	Beta-galactosidase 1 Beta-hexosaminidase subunit A1 Beta-hexosaminidase subunit A2 Beta-hexosaminidase subunit B1 Beta-hexosaminidase subunit B2 beta-N-acetylhexosaminidase	P13723 Q54GE1 Q54K55 Q54K56 Q54MU9 Q54SC9	glb1 hexa1 hexa2 hexb1 hexb2 nagA nagE	Dictyostelium discoideum	G09546QO G20239CJ G27025MB G50451AA G80016QC G82768YB
CS/DS degradation	Beta-hexosaminidase subunit A1 Beta-hexosaminidase subunit A2 Beta-hexosaminidase subunit B1 Beta-hexosaminidase subunit B2 Beta-xylosidase-like protein beta-N-acetylhexosaminidase	P13723 Q54J53 Q54K55 Q54K56 Q54MU9 Q54SC9	DDB_G0288289 hexa1 hexa2 hexb1 hexb2 nagA nagE	Dictyostelium discoideum	G27025MB
Hyaluronan uptake and degradation	Beta-hexosaminidase subunit A1 Beta-hexosaminidase subunit A2 Beta-hexosaminidase subunit B1 Beta-hexosaminidase subunit B2 beta-N-acetylhexosaminidase	P13723 Q54K55 Q54K56 Q54MU9 Q54SC9	hexa1 hexa2 hexb1 hexb2 nagA nagE	Dictyostelium discoideum	G35674CY
G alpha (q) signalling events	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase G-protein alpha subunit family protein Guanine nucleotide-binding protein alpha-1 subunit Guanine nucleotide-binding protein alpha-12 subunit Guanine nucleotide-binding protein alpha-2 subunit Guanine nucleotide-binding protein alpha-3 subunit Guanine nucleotide-binding protein alpha-4 subunit Guanine nucleotide-binding protein alpha-5 subunit Guanine nucleotide-binding protein alpha-6 subunit Guanine nucleotide-binding protein alpha-7 subunit Guanine nucleotide-binding protein alpha-8 subunit Guanine nucleotide-binding protein-like alpha-10 subunit Guanine nucleotide-binding protein-like alpha-11 subunit RGS domain-containing protein RGS domain-containing protein RGS domain-containing protein RGS domain-containing protein RGS domain-containing protein RGS domain-containing protein	P16051 P16894 P34042 P34043 P34044 P34045 P34046 Q02158 Q54KV6 Q54LD1 Q54M81 Q54S99 Q54UG5 Q54VG1 Q54XJ6 Q556I3 Q55E55 Q55EP5 Q8T130	DDB_G0270858 DDB_G0273033 DDB_G0278897 DDB_G0282583 DDB_G0286173 DDB_G0286817 Ga3 gbqA gpa10 gpa11 gpa12 gpaA gpaB gpaC gpaD gpaE gpaF gpaG gpaH gpaJ gpaK gpaL pipA plc	Dictyostelium discoideum
PLC beta mediated events	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase G-protein alpha subunit family protein Guanine nucleotide-binding protein alpha-1 subunit Guanine nucleotide-binding protein alpha-12 subunit Guanine nucleotide-binding protein alpha-2 subunit Guanine nucleotide-binding protein alpha-3 subunit Guanine nucleotide-binding protein alpha-4 subunit Guanine nucleotide-binding protein alpha-5 subunit Guanine nucleotide-binding protein alpha-6 subunit Guanine nucleotide-binding protein alpha-7 subunit Guanine nucleotide-binding protein alpha-8 subunit Guanine nucleotide-binding protein-like alpha-10 subunit Guanine nucleotide-binding protein-like alpha-11 subunit	P16051 P16894 P34042 P34043 P34044 P34045 P34046 Q02158 Q54KV6 Q54UG5 Q54VG1 Q55EP5 Q8T130	Ga3 gbqA gpa10 gpa11 gpa12 gpaA gpaB gpaC gpaD gpaE gpaF gpaG gpaH gpaJ gpaK gpaL pipA plc	Dictyostelium discoideum
Phase I - Functionalization of compounds	Aldehyde dehydrogenase family 3 comG Carboxylic ester hydrolase Carboxylic ester hydrolase Carboxylic ester hydrolase Carboxylic ester hydrolase Crystal protein Cytochrome P450 monooxygenase 521A1 Cytochrome b5 B Cytochrome b5 C FYVE-type domain-containing protein Molybdenum cofactor sulfurase domain-containing protein Molybdenum cofactor sulfurase domain-containing protein Molybdenum cofactor sulfurase domain-containing protein Molybdenum cofactor sulfurase domain-containing protein NADH-cytochrome b5 reductase 1 Probable cytochrome P450 508A1 Probable cytochrome P450 508A2 Probable cytochrome P450 508A3 Probable cytochrome P450 508A4 Probable cytochrome P450 508B1 Probable cytochrome P450 508C1 Probable cytochrome P450 508D1 Probable cytochrome P450 515A1 Probable cytochrome P450 515B1 Probable cytochrome P450 516A1 Probable cytochrome P450 516B1 Probable cytochrome P450 517A1 Probable cytochrome P450 517A2 Probable cytochrome P450 517A4 Probable cytochrome P450 518A1 Probable cytochrome P450 518B1 Probable cytochrome P450 519B1 Probable cytochrome P450 519D1 Probable cytochrome P450 519E1 Probable cytochrome P450 522A1 Probable cytochrome P450 554A1 Probable cytochrome P450 555A1 cAMP-regulated D2 protein	P18142 P21837 Q1ZXA1 Q1ZXA4 Q1ZXF3 Q1ZXF5 Q1ZXG3 Q1ZXL2 Q1ZXL7 Q54CS3 Q54DG1 Q54DT2 Q54EM5 Q54ET7 Q54JB6 Q54LA8 Q54LT7 Q54N21 Q54NC1 Q54NY3 Q54Q53 Q54QD0 Q54QD2 Q54QI3 Q54SK0 Q54SV9 Q54WD8 Q54XT7 Q54YY9 Q54ZM4 Q556M4 Q556M5 Q55AJ4 Q55D22 Q86A22 Q86L18 Q86L22 Q8MYE6	D2 DDB_G0270652 DDB_G0275953 DDB_G0276969 DDB_G0277999 DDB_G0279717 DDB_G0283819 DDB_G0285555 DDB_G0288165 DDB_G0291344 comG cryS cyb5B cyb5C cyb5r1 cyp508A1-1 cyp508A1-2 cyp508A2-1 cyp508A2-2 cyp508A3-1 cyp508A3-2 cyp508A4 cyp508B1 cyp508C1 cyp508D1 cyp515A1 cyp515B1 cyp516A1 cyp516B1 cyp517A1 cyp517A2 cyp517A4 cyp518A1 cyp518B1 cyp519B1 cyp519D1 cyp519E1 cyp521A1 cyp522A1 cyp554A1 cyp555A1 ostA ostB	Dictyostelium discoideum
Aspirin ADME	ABC transporter C family member 10 ABC transporter C family member 12 ABC transporter C family member 3 ABC transporter C family member 5 ABC transporter C family member 8 Carboxylic ester hydrolase Carboxylic ester hydrolase Carboxylic ester hydrolase Carboxylic ester hydrolase Crystal protein Cytochrome P450 monooxygenase 521A1 Glycosyl transferase family 28 C-terminal domain-containing protein Glycosyltransferase family 28 N-terminal domain-containing protein Glycosyltransferase family 28 N-terminal domain-containing protein Probable cytochrome P450 508A1 Probable cytochrome P450 508A2 Probable cytochrome P450 508A3 Probable cytochrome P450 508A4 Probable cytochrome P450 508B1 Probable cytochrome P450 508C1 Probable cytochrome P450 508D1 Probable cytochrome P450 515A1 Probable cytochrome P450 515B1 Probable cytochrome P450 516A1 Probable cytochrome P450 516B1 Probable cytochrome P450 517A1 Probable cytochrome P450 517A2 Probable cytochrome P450 517A4 Probable cytochrome P450 518A1 Probable cytochrome P450 518B1 Probable cytochrome P450 519B1 Probable cytochrome P450 519D1 Probable cytochrome P450 519E1 Probable cytochrome P450 522A1 Probable cytochrome P450 554A1 Probable cytochrome P450 555A1 cAMP-regulated D2 protein	P18142 P21837 Q1ZXA1 Q1ZXA4 Q1ZXF3 Q1ZXF5 Q1ZXG3 Q1ZXL2 Q1ZXL7 Q54CS3 Q54DT2 Q54EM5 Q54ET7 Q54JR2 Q54LA8 Q54LE6 Q54LT7 Q54N21 Q54NY3 Q54P13 Q54Q53 Q54QD0 Q54QD2 Q54SK0 Q54SV9 Q54U44 Q54WD8 Q54ZM4 Q556M4 Q556M5 Q55AJ4 Q55FB2 Q55FX8 Q55FY0 Q86A22 Q86L18 Q8ST87	D2 DDB_G0268184 DDB_G0276969 DDB_G0279717 DDB_G0285555 DDB_G0291344 abcC10 abcC12 abcC3 abcC5 abcC8 cryS cyp508A1-1 cyp508A1-2 cyp508A2-1 cyp508A2-2 cyp508A3-1 cyp508A3-2 cyp508A4 cyp508B1 cyp508C1 cyp508D1 cyp515A1 cyp515B1 cyp516A1 cyp516B1 cyp517A1 cyp517A2 cyp517A4 cyp518A1 cyp518B1 cyp519B1 cyp519D1 cyp519E1 cyp521A1 cyp522A1 cyp554A1 cyp555A1 ostA ostB ugt2 ugt3	Dictyostelium discoideum
Synthesis of PC	Abhydrolase domain-containing protein CTL-like protein DDB_G0288717 Carboxylic ester hydrolase Carboxylic ester hydrolase Carboxylic ester hydrolase Carboxylic ester hydrolase Choline transporter-like protein 2 Crystal protein Major facilitator superfamily (MFS) profile domain-containing protein Phosphatidylethanolamine N-methyltransferase A Uncharacterized CDP-alcohol phosphatidyltransferase class-I family protein 1 Uncharacterized CDP-alcohol phosphatidyltransferase class-I family protein 2 Uncharacterized CDP-alcohol phosphatidyltransferase class-I family protein 3 Uncharacterized CDP-alcohol phosphatidyltransferase class-I family protein 4 cAMP-regulated D2 protein choline-phosphate cytidylyltransferase phosphatidate phosphatase	P18142 P21837 Q54ET7 Q54GD2 Q54H38 Q54I48 Q54IJ2 Q54N21 Q54SD5 Q54SX3 Q54WD8 Q54XM0 Q550W1 Q55AQ3 Q75JA1 Q86L18 Q8T2Q6	D2 DDB_G0271730 DDB_G0276969 DDB_G0279717 DDB_G0282159 DDB_G0285555 DDB_G0288717 DDB_G0290229 DDB_G0291344 DG1056 abhd captA captB captC captD cryS ctl2 lipB pemtA slc44a2	Dictyostelium discoideum
Metabolism of Angiotensinogen to Angiotensins	Carboxylic ester hydrolase Carboxylic ester hydrolase Carboxylic ester hydrolase Carboxylic ester hydrolase Crystal protein cAMP-regulated D2 protein	P18142 P21837 Q54ET7 Q54N21 Q54WD8 Q86L18	D2 DDB_G0276969 DDB_G0279717 DDB_G0285555 DDB_G0291344 cryS	Dictyostelium discoideum
Neurotransmitter clearance	Carboxylic ester hydrolase Carboxylic ester hydrolase Carboxylic ester hydrolase Carboxylic ester hydrolase Crystal protein cAMP-regulated D2 protein	P18142 P21837 Q54ET7 Q54N21 Q54WD8 Q86L18	D2 DDB_G0276969 DDB_G0279717 DDB_G0285555 DDB_G0291344 cryS	Dictyostelium discoideum
Physiological factors	Carboxylic ester hydrolase Carboxylic ester hydrolase Carboxylic ester hydrolase Carboxylic ester hydrolase Crystal protein cAMP-regulated D2 protein	P18142 P21837 Q54ET7 Q54N21 Q54WD8 Q86L18	D2 DDB_G0276969 DDB_G0279717 DDB_G0285555 DDB_G0291344 cryS	Dictyostelium discoideum
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion	Inositol 1,4,5-trisphosphate receptor-like protein A Ras guanine nucleotide exchange factor P Ras guanine nucleotide exchange factor W Ras-related protein rapA	P18613 Q54TK8 Q55GH9 Q9NA13	gefP gefW iplA rap1 rapA rasGEFP rasGEFW	Dictyostelium discoideum
Clathrin-mediated endocytosis	ABC transporter C family member 13 ABC transporter C family member 14 ABC transporter C family member 15 ABC transporter C family member 1 ABC transporter C family member 2 ABC transporter C family member 6 ABC transporter C family member 7 ABC transporter C family member 9 ANTH domain-containing protein AP-1 complex subunit beta AP-2 complex subunit alpha-2 AP-2 complex subunit mu AP-2 complex subunit sigma Ankyrin repeat-containing protein Autophagy-related protein 27 Autophagy-related protein 27 Clathrin heavy chain Clathrin light chain Epidermal growth factor receptor substrate 15 homolog GTPase activating protein homolog 1 Lysosome membrane protein 2-C MRH domain-containing protein MRH domain-containing protein MRH domain-containing protein NECAP PHear domain-containing protein PIPK domain-containing protein Phosphatidylinositol 3-kinase 1 Phosphatidylinositol 3-kinase 2 Phosphatidylinositol 3-kinase 3 Phosphatidylinositol 3-kinase Phosphatidylinositol 3-kinase Phosphatidylinositol-4-phosphate 5-kinase family protein Phosphatidylinositol-4-phosphate 5-kinase family protein Probable phosphatidylinositol phosphate kinase DDB_G0267588 SH3 and F-BAR domain-containing protein DDB_G0271676 SH3 and F-BAR domain-containing protein DDB_G0274695 SH3 domain-containing protein Sugar transporter family protein Synaptobrevin-A Synaptobrevin-B Transmembrane protein Uncharacterized protein Uncharacterized protein	P25870 P54672 P54673 P54674 P54675 Q54CZ8 Q54DL4 Q54EK2 Q54F55 Q54GB3 Q54GD0 Q54H39 Q54K24 Q54KI4 Q54LD2 Q54M96 Q54NL1 Q54S78 Q54U74 Q54UC8 Q54V86 Q54VC1 Q54VJ0 Q54VR4 Q54WQ8 Q54X82 Q54XB6 Q54Y50 Q555L8 Q556H0 Q55AN3 Q55FQ9 Q55FX5 Q55GN6 Q6TMJ9 Q75JD4 Q86A02 Q86KI1 Q86KK4 Q86KL3 Q8MN58 Q8T6H3 Q8T6H8	DDB_G0267588 DDB_G0271676 DDB_G0271812 DDB_G0272638 DDB_G0274261 DDB_G0274695 DDB_G0279059 DDB_G0279493 DDB_G0280377 DDB_G0281155 DDB_G0281235 DDB_G0286115 DDB_G0286699 DDB_G0292190 DDB_G0292610 PIPkinA abcC1 abcC13 abcC14 abcC15 abcC2 abcC6 abcC7 abcC9 ap1b1 ap2a1-1 ap2a1-2 ap2s1 apm1 apm2 apmA chcA clc clcA clmA eps15 gacBB lmpC mgp1 mrrA pik1 pik2 pik3 pikA pikB pikC pikF pikG pikH sybA sybB	Dictyostelium discoideum
LDL clearance	AP-1 complex subunit beta AP-2 complex subunit alpha-2 AP-2 complex subunit mu AP-2 complex subunit sigma Carboxylic ester hydrolase Clathrin heavy chain Clathrin light chain Countin-3 FYVE-type domain-containing protein Kynurenine formamidase MD-2-related lipid-recognition domain-containing protein MD-2-related lipid-recognition domain-containing protein Putative phosphatidylglycerol/phosphatidylinositol transfer protein 1 Putative phosphatidylglycerol/phosphatidylinositol transfer protein 2 Putative phosphatidylglycerol/phosphatidylinositol transfer protein 3 Putative phosphatidylglycerol/phosphatidylinositol transfer protein DDB_G0278295 Putative phosphatidylglycerol/phosphatidylinositol transfer protein DDB_G0282107 Putative phosphatidylglycerol/phosphatidylinositol transfer protein DDB_G0282179 Putative phosphatidylglycerol/phosphatidylinositol transfer protein DDB_G0285639 SSD domain-containing protein	P25870 P54672 Q54ET7 Q54H39 Q54KP7 Q54MV4 Q54QI3 Q54R44 Q54SW1 Q54SW2 Q54SZ8 Q54SZ9 Q54TL9 Q54X82 Q54YD2 Q551C5 Q55BL4 Q86HV8 Q86KI1 Q8MN58	DDB_G0270454 DDB_G0276657 DDB_G0278295 DDB_G0281675 DDB_G0282107 DDB_G0282109 DDB_G0282177 DDB_G0282179 DDB_G0283413 DDB_G0283819 DDB_G0285639 DDB_G0287185 DDB_G0291344 ap1b1 ap2a1-1 ap2a1-2 ap2s1 apm1 apm2 apmA chcA clc clcA ctnC	Dictyostelium discoideum

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