GlyCosmos Portal

GlyCosmos Pathways

Integrated of pathway data, containing glycoproteins and glycans obtained from Reactome and the Metabolism of carbohydrates in Escherichia coli O-antigens obtained from ECODAB. Search by pathway name, species, and protein name.

Source	Last Updated
Reactome	March 20, 2024
ECODAB	April 1, 2019

Displaying entries **151 - 175** of **1070** in total

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Pathway Name	Protein Name	UniProt ID	Gene Symbol	Organism
Peptide chain elongation	Elongation factor 2	P05197	Eef2	Rattus norvegicus (Norway rat)
COX reactions	Prostaglandin G/H synthase 1	Q63921	Cox-1 Cox1 Ptgs1	Rattus norvegicus (Norway rat)
Activation of BAD and translocation to mitochondria	14-3-3 protein beta/alpha 14-3-3 protein epsilon 14-3-3 protein eta 14-3-3 protein gamma 14-3-3 protein theta 14-3-3 protein zeta/delta Bcl2-associated agonist of cell death Calcineurin subunit B type 1 Serine/threonine-protein phosphatase Stratifin	E2CWF0 G3V9A3 O35147 P35213 P61983 P62260 P63100 P63102 P68255 P68511	Bad Cna2 Cnb Msfs1 Ppp3cc Ppp3r1 Sfn Ywhab Ywhae Ywhag Ywhah Ywhaq Ywhaz	Rattus norvegicus (Norway rat)
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain	CCR4-NOT transcription complex subunit 10 CCR4-NOT transcription complex subunit 11 CCR4-NOT transcription complex subunit 6 CCR4-NOT transcription complex subunit 9 CCR4-NOT transcription complex, subunit 1 CCR4-NOT transcription complex, subunit 2 CCR4-NOT transcription complex, subunit 3 CCR4-NOT transcription complex, subunit 4 Centromere protein J M-phase inducer phosphatase Nucleophosmin Protein BTG2 Serine/threonine-protein kinase PLK2 Serine/threonine-protein kinase PLK3 Tankyrase 1 binding protein 1 poly(A)-specific ribonuclease	A0A8I6AJD1 A0A8I6AL98 B0BNA9 D3ZF26 D3ZUV9 D4A194 D4ADT2 G3V7M0 P13084 P27049 Q498M7 Q5PQL2 Q5XIA4 Q6AXU9 Q9R011 Q9R012	Btg2 Ccr4 Cdc25c Cenpj Cnk Cnot1 Cnot10 Cnot11 Cnot2 Cnot3 Cnot4 Cnot6 Cnot6l Cnot9 Fnk Npm1 Pc3 Plk2 Plk3 Rcd1 Rqcd1 Snk Tnks1bp1	Rattus norvegicus (Norway rat)
Transport of vitamins, nucleosides, and related molecules	Acetyl-coenzyme A transporter 1 PDZ domain-containing protein 11 Sodium-dependent multivitamin transporter	A0A8I6A9Z8 O70247 Q6AYY8	Acatn Pdzd11 Slc33a1 Slc5a6 Smvt	Rattus norvegicus (Norway rat)
Beta oxidation of butanoyl-CoA to acetyl-CoA	Enoyl-CoA hydratase, mitochondrial Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial Short-chain specific acyl-CoA dehydrogenase, mitochondrial	P14604 P15651 Q9WVK7	Acads Echs1 Had Hadh Hadhsc Schad	Rattus norvegicus (Norway rat)
Asparagine N-linked glycosylation	Asialoglycoprotein receptor 1 Asialoglycoprotein receptor 2 Beta-1,4-N-acetyl-galactosaminyl transferase 2 Uromodulin	A0A8I6AAQ3 P02706 P08290 P27590	Asgr-1 Asgr-2 Asgr1 Asgr2 B4galnt2 Umod	Rattus norvegicus (Norway rat)
Acyl chain remodeling of CL	Cytosolic phospholipase A2 Lysocardiolipin acyltransferase 1 Tafazzin family protein Trifunctional enzyme subunit alpha, mitochondrial Trifunctional enzyme subunit beta, mitochondrial	A0A0G2K0X0 A0A8I6AFV0 P50393 Q60587 Q64428	Cpla2 Hadha Hadhb Lclat1 Pla2g4 Pla2g4a TAZ Tafazzin	Rattus norvegicus (Norway rat)
Endosomal/Vacuolar pathway	Beta-2-microglobulin HLA class I histocompatibility antigen, A-24 alpha chain-like Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Leucyl-cystinyl aminopeptidase MHC class Ib antigen RT1 class I, M1, 5 RT1 class I, M1, gene 2 RT1 class I, M10, gene 1 RT1 class I, locus CE14 RT1 class I, locus CE16 RT1 class I, locus CE16 RT1 class I, locus CE3 RT1 class I, locus M1, gene 4 RT1 class Ia, locus A1 RT1 class Ia, locus A2 RT1 class Ib, locus M3, gene 1 RT1 class Ib, locus M5 RT1 class Ib, locus N3 RT1 class Ib, locus S3	A0A0G2K1E1 A0A0G2K4S5 A0A0G2K881 A0A8I5YC56 A0A8I5ZTS2 A0A8I5ZYQ2 A0A8I6ADU9 A0A8I6AK64 A0A8I6ASE5 A0A8I6GE62 A0A8J8XB15 A0A8J8Y6P7 A0A8J8YPS9 E9PTZ7 E9PTZ9 F1LQF2 F1MAR7 P07151 P97629 Q6MFZ3 Q6MFZ4 Q6W9J5	1700031A10Rik 2781a1 2788a1a2 2795a1 2800a1a2 2812a1a2 2824a1 2829a1a2 2846a1a2 2860a1 2865a2 2869a1a2 2879a1 2886a1-a1a2 2901a1a2 2906a1 2920a1a2 2927a1 2941a1a2 2945a1a2 2950a1 2953a1a2 2959a1 2976a1 2981a1a2 2984a1a2 2994a1 3082ex4-5 3252a3 3258a2 3281a3 3298a3 AABR07044308.2 AABR07044362.1 AABR07072807.1 AC120486.1 B2m ENSRNOG00000064836 ENSRNOG00000069480 H2-M10.6 H2-M10.6l Irap LOC102546590 LOC120093125 Lnpep Nerg-ps11 Nerg-ps12 Nerg-ps13 Nerg-ps14 Nerg-ps15 Otase Pbp-ps Ppid-ps Ppp1cb-ps RT1-A1 RT1-A2 RT1-CE1 RT1-CE11 RT1-CE14 RT1-CE16 RT1-CE2 RT1-M1-1 RT1-M1-2 RT1-M1-3 RT1-M1-4 RT1-M1-5 RT1-M10-1 RT1-M10-2 RT1-M10-3 RT1-M10-4 RT1-M2 RT1-M3-1 RT1-M5 RT1-M7 RT1-M8 RT1-N3 RT1-O1l1 RT1-P2 RT1-S3 Rcrg1-ps25 Rcrg1-ps26 Rcrg1-ps27 Rcrg1-ps28 Rcrg1-ps29 Rcrg1-ps30 Rcrg1-ps31 Rcrg1-ps32 Rcrg1-ps33 Rcrg1-ps34 Rcrg1-ps35 Rcrg1-ps36 Rcrg1-ps37 Rcrg1-ps38 Rcrg1-ps39 Rcrg1-ps40 Rpl39-ps Trim15 Trim31 Trim39-ps	Rattus norvegicus (Norway rat)
Organic anion transport	Organic anion transporter 3 Solute carrier family 22 member 12 Solute carrier family 22 member 6 Solute carrier family 22 member 7	O35956 Q3ZAV1 Q5RLM2 Q9R1U7	Nlt Oat1 Oat2 Oat3 Slc22a12 Slc22a6 Slc22a7 Slc22a8 Urat1	Rattus norvegicus (Norway rat)
Activation of C3 and C5	Complement C2 Complement C3 Complement C4 Complement C4B (Chido blood group) Complement C5	A0A8J8YKQ8 P01026 P08649 P08650 Q6MG90	C2 C3 C4 C4a C4b C5 Cfb	Rattus norvegicus (Norway rat)
Synthesis of PE	Choline kinase alpha Choline/ethanolamine kinase Choline/ethanolaminephosphotransferase 1 Ethanolamine kinase 2 Ethanolamine-phosphate cytidylyltransferase Ethanolamine-phosphate phospho-lyase Phosphoethanolamine/phosphocholine phosphatase 1 Selenoprotein I ethanolamine kinase phosphatidate phosphatase phosphatidate phosphatase phosphatidate phosphatase	A0A0G2JW03 A0A0G2JY62 A0A8I6AUU1 B4F7D7 D3ZRW8 D3ZXB8 G3V6P4 M0R7F6 O54783 O88637 Q01134 Q6AXM5	Cept1 Chetk Chk Chka Chkb Chkl Ckr Ept1 Etnk1 Etnk2 Etnppl LOC687071 Lpin1 Lpin2 Lpin3 Pcyt2 Phospho1 Selenoi	Rattus norvegicus (Norway rat)
EGFR downregulation	Amphiregulin Betacellulin Cell division control protein 42 homolog E3 ubiquitin-protein ligase CBL Endophilin-A1 Endophilin-A2 Endophilin-A3 Epidermal growth factor receptor pathway substrate 15-like 1 Epidermal growth factor receptor pathway substrate 15 Epsin-1 Growth factor receptor-bound protein 2 Hepatocyte growth factor-regulated tyrosine kinase substrate Polyubiquitin-B Polyubiquitin-C Pro-epidermal growth factor Proepiregulin Proheparin-binding EGF-like growth factor Protein sprouty homolog 1 Protein sprouty homolog 2 Protransforming growth factor alpha Receptor protein-tyrosine kinase Rho guanine nucleotide exchange factor 7 SH3 domain-containing kinase-binding protein 1 Signal transducing adapter molecule 2 Signal transducing adaptor molecule Tyrosine-protein phosphatase non-receptor type 12 Tyrosine-protein phosphatase non-receptor type Ubiquitin B-like Ubiquitin-ribosomal protein eS31 fusion protein	A0A8I5YC99 A0A8I6A5Y3 A0A8I6A726 A0A8I6AQ55 A0A8I6G3R2 B5DF55 B5DFH3 F1LQQ5 G3V6K6 G3V7Q4 O35179 O35180 O35964 O55043 O88339 P01134 P07522 P0CG51 P24338 P62982 P62994 Q06175 Q5HZA2 Q5XHY7 Q63429 Q8CFN2 Q925Q9 Q9JJ50 Q9Z0L5	Areg Arhgef7 Ash Btc Cbl Cdc42 Dtr Egf Egfr Epn1 Eps15 Eps15l1 Ereg Grb2 Hbegf Hegfl Hgs Hrs Hrs2 LOC100360645 Pak3bp Pixb Ptpn12 Ptpn3 Rps27a Ruk Sdgf Seta Sh3d2a Sh3d2c1 Sh3gl1 Sh3gl2 Sh3gl3 Sh3kbp1 Sh3p13 Sh3p4 Sh3p8 Spry1 Spry2 Stam Stam2 Tgfa Uba80 Ubb Ubbl1 Ubc Ubcep1 Ubcl1	Rattus norvegicus (Norway rat)
Assembly of the pre-replicative complex	26S proteasome non-ATPase regulatory subunit 10 26S proteasome non-ATPase regulatory subunit 11 26S proteasome non-ATPase regulatory subunit 13 26S proteasome non-ATPase regulatory subunit 1 26S proteasome non-ATPase regulatory subunit 2 26S proteasome non-ATPase regulatory subunit 5 26S proteasome non-ATPase regulatory subunit 6 26S proteasome non-ATPase regulatory subunit 8 26S proteasome non-ATPase regulatory subunit 9 26S proteasome regulatory subunit 4 26S proteasome regulatory subunit 6A 26S proteasome regulatory subunit 6B 26S proteasome regulatory subunit 7 26S proteasome regulatory subunit 8 Anaphase promoting complex subunit 1 Anaphase promoting complex subunit 7 Anaphase-promoting complex subunit 15 Anaphase-promoting complex subunit 16 Anaphase-promoting complex subunit 2 Anaphase-promoting complex subunit 4 Anaphase-promoting complex subunit 5 Anaphase-promoting complex subunit CDC26 Cell division cycle 16 Cell division cycle 23 Cell division cycle protein 27 homolog Chromatin licensing and DNA replication factor 1 DNA replication licensing factor MCM2 DNA replication licensing factor MCM3 DNA replication licensing factor MCM4 DNA replication licensing factor MCM5 E2 ubiquitin-conjugating enzyme Fizzy and cell division cycle 20 related 1 Geminin, DNA replication inhibitor Polyubiquitin-B Polyubiquitin-C Proteasome (Prosome, macropain) 26S subunit, non-ATPase, 12 Proteasome (Prosome, macropain) 26S subunit, non-ATPase, 14 Proteasome 26S subunit, ATPase 6 Proteasome 26S subunit, non-ATPase 3 Proteasome 26S subunit, non-ATPase 7 Proteasome activator complex subunit 1 Proteasome activator complex subunit 2 Proteasome inhibitor PI31 subunit Proteasome subunit alpha type-1 Proteasome subunit alpha type-2 Proteasome subunit alpha type-3 Proteasome subunit alpha type-4 Proteasome subunit alpha type-5 Proteasome subunit alpha type-6 Proteasome subunit alpha type-7 Proteasome subunit beta type-10 Proteasome subunit beta type-1 Proteasome subunit beta type-2 Proteasome subunit beta type-3 Proteasome subunit beta type-4 Proteasome subunit beta type-5 Proteasome subunit beta type-6 Proteasome subunit beta type-7 Proteasome subunit beta type-8 Proteasome subunit beta type-9 Proteasome subunit beta Ubiquitin B-like Ubiquitin-conjugating enzyme E2 C Ubiquitin-conjugating enzyme E2 D1 Ubiquitin-conjugating enzyme E2 S Ubiquitin-ribosomal protein eS31 fusion protein	A0A0G2JSL0 A0A8I5ZM79 A0A8I5ZNE7 A0A8I6A4J8 A0A8I6A5Y3 A0A8I6AE10 A0A8I6ANL9 A1L1K3 B0BN93 B1WCA1 B5DFI8 D3ZDK2 D3ZDN9 D3ZFP4 D3ZIT4 D3ZKD4 D3ZP96 D3ZQX4 D3ZUB7 D3ZUW6 D3ZWJ0 E9PTS4 F1LMQ3 F1LMZ8 F1M3L4 F7EWF8 F7FGV7 G3V681 G3V6W6 G3V8G2 O88761 P0CG51 P17220 P18420 P18421 P18422 P21670 P28064 P28073 P28075 P28077 P34064 P34067 P40112 P40307 P48004 P60901 P62193 P62198 P62982 Q4FZT9 Q4KM35 Q4V8A2 Q4V8E2 Q5XIC6 Q5XIU5 Q63347 Q63429 Q63569 Q63570 Q63797 Q63798 Q6YDN7 Q9JHW0 Q9WTV5 Q9Z2X3	Anapc1 Anapc15 Anapc16 Anapc2 Anapc4 Anapc5 Anapc7 Cdc16 Cdc23 Cdc26 Cdc27 Cdt1 Fzr1 Gmnn LOC100360645 LOC100360846 LOC100365869 LOC100366017 Lmp10 Lmp2 Mcm2 Mcm3 Mcm4 Mcm5 Mecl1 Mss1 Psma1 Psma2 Psma3 Psma4 Psma5 Psma6 Psma7 Psmb1 Psmb10 Psmb2 Psmb3 Psmb4 Psmb5 Psmb6 Psmb6l Psmb6l1 Psmb7 Psmb8 Psmb9 Psmc1 Psmc2 Psmc3 Psmc4 Psmc5 Psmc6 Psmd1 Psmd10 Psmd11 Psmd12 Psmd13 Psmd14 Psmd2 Psmd3 Psmd5 Psmd6 Psmd7 Psmd8 Psmd9 Psme1 Psme2 Psmf1 Ring12 Rps27a Sug1 Tbp1 Tbp7 Uba80 Ubb Ubbl1 Ubc Ubcep1 Ubcl1 Ube2c Ube2d1 Ube2e1 Ube2s	Rattus norvegicus (Norway rat)
Transport of Mature mRNA derived from an Intron-Containing Transcript	ATP-dependent RNA helicase DDX39A Aladin WD repeat nucleoporin Aly/REF export factor Cdc40 protein Chromatin target of PRMT1 protein DNA polymerase delta interacting protein 3 Eukaryotic initiation factor 4A-III LOC683983 protein Mago homolog B, exon junction complex subunit NTF2-related export protein Nuclear RNA export factor 1 Nuclear RNA export factor 2 Nuclear RNA export factor 5 Nuclear RNA export factor 7 Nuclear cap-binding protein subunit 1 Nuclear cap-binding protein subunit 2 Nuclear envelope pore membrane protein POM 121 Nuclear pore complex protein Nup107 Nuclear pore complex protein Nup153 Nuclear pore complex protein Nup155 Nuclear pore complex protein Nup50 Nuclear pore complex protein Nup54 Nuclear pore complex protein Nup85 Nuclear pore complex protein Nup88 Nuclear pore complex protein Nup93 Nuclear pore complex protein Nup98-Nup96 Nuclear pore glycoprotein p62 Nuclear pore membrane glycoprotein 210 Nucleoporin 133 Nucleoporin 160 Nucleoporin 205 Nucleoporin 214 Nucleoporin 37 Nucleoporin NDC1 Nucleoporin NUP188 Nucleoporin NUP35 Nucleoporin NUP42 Nucleoporin p58/p45 Nucleoprotein TPR Pre-mRNA-splicing factor SLU7 Protein CASC3 Protein SEC13 homolog Protein mago nashi homolog RAN binding protein 2 RNA helicase RNA-binding protein 8A RNA-binding protein with serine-rich domain 1 RRM domain-containing protein SAP domain-containing ribonucleoprotein Serine and arginine repetitive matrix 1 Serine and arginine rich splicing factor 11 Serine and arginine rich splicing factor 3 Serine and arginine rich splicing factor 7 Serine/arginine-rich splicing factor 1 Serine/arginine-rich splicing factor 2 Serine/arginine-rich splicing factor 5 Serine/arginine-rich splicing factor 9 Spliceosome RNA helicase Ddx39b Splicing factor U2AF 26 kDa subunit Splicing factor U2AF subunit THO complex subunit 2 THO complex subunit 5 homolog THO complex subunit 6 homolog THO complex subunit 7 homolog U2 small nuclear RNA auxiliary factor 1 UAP56-interacting factor UPF3B, regulator of nonsense mediated mRNA decay mRNA export factor GLE1 mRNA export factor	A0A0G2JXM5 A0A0G2K3M4 A0A0G2K8V3 A0A0G2QC38 A0A0U1RRP3 A0A8I5YC36 A0A8I5YCH6 A0A8I5ZJ67 A0A8I5ZSN8 A0A8I5ZV21 A0A8I5ZV38 A0A8I6A2P1 A0A8I6A9Y1 A0A8I6ABD9 A0A8I6AFZ5 A0A8I6AKZ6 A0A8I6GMR8 B0BNB5 B1WC40 B2RYC1 B2RZ65 D3Z8B2 D3ZBL6 D3ZGV3 D3ZHV0 D4A321 D4ACK1 F1LRC6 F1M0X6 F1MA98 F7FPN7 M0RBB1 O08587 O08658 O88984 P11654 P17955 P37199 P49791 P49793 P52590 P52591 P70581 P70582 Q09167 Q27W01 Q27W02 Q3B8Q2 Q3SWS8 Q498T2 Q498U4 Q4KLN4 Q4QQS8 Q56A27 Q5PPI1 Q5U216 Q5XFW8 Q63413 Q66HC5 Q68FX7 Q68FY1 Q6AXN4 Q6AY87 Q6AYK1 Q6PDU1 Q7TP17 Q7TQ84 Q80ZG5 Q8K3X0	AABR07026797.1 Aaas Alyref Bat1 Bat1a Casc3 Cbp20 Cbp80 Cdc40 Chtop Cl-4 Ddx39 Ddx39a Ddx39b Ddx48 Ddxl Dhx38 Eif4a3 Fmip Fop Fyttd1 Gle1 Gle1l Gp210 Hcc1 Hrs LOC683983 Magoh Magohb Mln51 Mrnp41 Ncbp1 Ncbp2 Ndc1 Npap60 Nup107 Nup121 Nup133 Nup153 Nup155 Nup160 Nup188 Nup205 Nup210 Nup214 Nup35 Nup37 Nup42 Nup43 Nup50 Nup53 Nup54 Nup58 Nup62 Nup84 Nup85 Nup88 Nup93 Nup98 Nupl1 Nupl2 Nxf1 Nxf2 Nxf5 Nxf7 Nxt1 Pcnt1 Pdrp Poldip3 Pom121 Pom210 Rae1 Ranbp2 Rbm8 Rbm8a Rnps1 Sarnp Sec13 Sec13l1 Sfrs2 Sfrs5 Sfrs9 Slu7 Srrm1 Srsf1 Srsf11 Srsf2 Srsf3 Srsf5 Srsf7 Srsf9 Tap Thoc2 Thoc5 Thoc6 Thoc7 Tmem48 Tpr U2af1 U2af1l4 U2af2 Uap56 Uif Upf3b wdr58	Rattus norvegicus (Norway rat)
MDK and PTN in ALK signaling	Midkine Pleiotrophin Receptor-type tyrosine-protein phosphatase zeta Tyrosine-protein kinase receptor	F1LRZ0 P63090 Q62656 Q9R1S9	Alk Mdk Ptn Ptprz Ptprz1 Ptpz	Rattus norvegicus (Norway rat)
PRPP biosynthesis	Ribose-phosphate pyrophosphokinase 1 Ribose-phosphate pyrophosphokinase 1 Ribose-phosphate pyrophosphokinase 2 Ribose-phosphate pyrophosphokinase N-terminal domain-containing protein ribose-phosphate diphosphokinase	A0A0G2JSV3 A0A8I6AC83 M0RBK1 P09330 P60892	ENSRNOG00000063771 LOC314140 Prps1 Prps1l1 Prps1l3 Prps2	Rattus norvegicus (Norway rat)
RUNX1 regulates transcription of genes involved in interleukin signaling	Core-binding factor subunit beta E74 like ETS transcription factor 1 Runt-related transcription factor 1	A0A8I6GMB2 G3V9V2 Q63046	Aml1 Cbfa2 Cbfb Elf1 Runx1	Rattus norvegicus (Norway rat)
Signalling to RAS	Growth factor receptor-bound protein 2 SHC-transforming protein 1 SHC-transforming protein 2 SHC-transforming protein 3 SOS Ras/Rac guanine nucleotide exchange factor 1	D4A3T0 O70142 O70143 P62994 Q5M824	Ash Grb2 Nshc Sck Shc1 Shc2 Shc3 Shcc Sos1	Rattus norvegicus (Norway rat)
Role of LAT2/NTAL/LAB on calcium mobilization	3-phosphoinositide-dependent protein kinase 1 GRB2-associated-binding protein 2 Growth factor receptor-bound protein 2 Ig kappa chain V-II region RPMI 6410-like Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Immunoglobulin V-set domain-containing protein Immunoglobulin V-set domain-containing protein Immunoglobulin V-set domain-containing protein Immunoglobulin heavy variable V12-3 Immunoglobulin kappa variable like, pseudogene 6 Immunoglobulin lambda constant 1 Immunoglobulin lambda-like polypeptide 1 Linker for activation of T-cells family member 2 MCG142154-like Phosphatidylinositol 3-kinase regulatory subunit alpha Phosphatidylinositol 3-kinase regulatory subunit beta Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform SHC-transforming protein 1 SOS Ras/Rac guanine nucleotide exchange factor 1 Similar to immunoglobulin light chain variable region Similar to immunoglobulin light chain Tyrosine-protein kinase Lyn Tyrosine-protein kinase SYK	A0A0G2JTV0 A0A0G2JW41 A0A0G2JY98 A0A0G2JZL1 A0A0G2K066 A0A0G2K180 A0A0G2K344 A0A0G2K3L5 A0A0G2K828 A0A0G2K8K8 A0A0G2K980 A0A0G2K9L1 A0A0G2K9Z5 A0A8I5Y130 A0A8I5Y662 A0A8I5Y735 A0A8I5Y7P7 A0A8I5Y806 A0A8I5Y9R1 A0A8I5Y9S1 A0A8I5YBU3 A0A8I5YC48 A0A8I5ZLU0 A0A8I5ZMM5 A0A8I5ZN60 A0A8I5ZNF0 A0A8I5ZNL8 A0A8I5ZNW4 A0A8I5ZPH3 A0A8I5ZRU2 A0A8I5ZTK7 A0A8I5ZVJ7 A0A8I5ZX10 A0A8I5ZX42 A0A8I5ZY02 A0A8I5ZYE2 A0A8I5ZYV4 A0A8I6A2E5 A0A8I6A3F2 A0A8I6A6C3 A0A8I6A7L1 A0A8I6A935 A0A8I6A938 A0A8I6A9W1 A0A8I6AA60 A0A8I6AAM9 A0A8I6ABH0 A0A8I6AC42 A0A8I6ACJ3 A0A8I6ACY1 A0A8I6AD89 A0A8I6AEB7 A0A8I6AEV5 A0A8I6AFL1 A0A8I6AFR0 A0A8I6AGR0 A0A8I6AH36 A0A8I6AHB9 A0A8I6AHQ4 A0A8I6AHX0 A0A8I6AI41 A0A8I6AJ98 A0A8I6AJF8 A0A8I6AK51 A0A8I6AKK2 A0A8I6ALZ6 A0A8I6AM09 A0A8I6AMX1 A0A8I6ANN1 A0A8I6AP25 A0A8I6AQD7 A0A8I6ASD7 A0A8I6AVW1 A0A8I6G3M2 A0A8I6G7J3 A0A8I6G8Z3 A0A8I6GC23 A0A8I6GE36 A0A8I6GHG7 A0A8I6GL55 A0A8I6GLJ8 D3ZE08 D3ZMS7 D3ZMY4 D3ZPL2 D4A3T0 F1LWD0 F1LYF1 F1LYU3 F1M7B3 F1MAM7 M0R5K1 M0R7F5 M0RBD5 M0RDZ5 O55173 P62994 Q07014 Q5M824 Q63787 Q63788 Q64725 Q8CGL2 Q9EQH1 Q9Z1L0	AABR07034730.2 AABR07060971.1 AABR07061001.1 AABR07065782.1 AABR07065808.1 AABR07065812.2 AABR07065813.1 Ash ENSRNOG00000062324 ENSRNOG00000062682 ENSRNOG00000062762 ENSRNOG00000062853 ENSRNOG00000062915 ENSRNOG00000062976 ENSRNOG00000063148 ENSRNOG00000063329 ENSRNOG00000063340 ENSRNOG00000063341 ENSRNOG00000063422 ENSRNOG00000063550 ENSRNOG00000063572 ENSRNOG00000063707 ENSRNOG00000063791 ENSRNOG00000064041 ENSRNOG00000064061 ENSRNOG00000064085 ENSRNOG00000064245 ENSRNOG00000064481 ENSRNOG00000064582 ENSRNOG00000065160 ENSRNOG00000065181 ENSRNOG00000065191 ENSRNOG00000065237 ENSRNOG00000065406 ENSRNOG00000065564 ENSRNOG00000065629 ENSRNOG00000065670 ENSRNOG00000065675 ENSRNOG00000065690 ENSRNOG00000065855 ENSRNOG00000066010 ENSRNOG00000066072 ENSRNOG00000066203 ENSRNOG00000066380 ENSRNOG00000066406 ENSRNOG00000066431 ENSRNOG00000066785 ENSRNOG00000066812 ENSRNOG00000066814 ENSRNOG00000066904 ENSRNOG00000066922 ENSRNOG00000066926 ENSRNOG00000066971 ENSRNOG00000067010 ENSRNOG00000067025 ENSRNOG00000067233 ENSRNOG00000067273 ENSRNOG00000067516 ENSRNOG00000067603 ENSRNOG00000067643 ENSRNOG00000067679 ENSRNOG00000067883 ENSRNOG00000068055 ENSRNOG00000068059 ENSRNOG00000068381 ENSRNOG00000068499 ENSRNOG00000068847 ENSRNOG00000069193 ENSRNOG00000069427 ENSRNOG00000069491 ENSRNOG00000069766 ENSRNOG00000069828 ENSRNOG00000069901 ENSRNOG00000069940 ENSRNOG00000070091 ENSRNOG00000070192 ENSRNOG00000070244 ENSRNOG00000070247 ENSRNOG00000070810 ENSRNOG00000070812 ENSRNOG00000070816 ENSRNOG00000070832 ENSRNOG00000070933 ENSRNOG00000070986 ENSRNOG00000071049 ENSRNOG00000071091 Gab2 Grb2 Igkv2-112l1 Igkv8-30l1 Igkvl-ps6 Igkvl10 Igkvl12 Igkvl13 Igkvl2 Iglc1 Igll1 LOC100363522 LOC100365500 LOC100911032 LOC102551948 LOC690813 Lab Lat2 Lyn Ntal Pdk1 Pdpk1 Pik3ca Pik3cb Pik3r1 Pik3r2 RGD1561722 RGD1564696 Shc1 Sos1 Syk Wbscr5	Rattus norvegicus (Norway rat)
RHO GTPases activate PKNs	14-3-3 protein beta/alpha 14-3-3 protein epsilon 14-3-3 protein eta 14-3-3 protein gamma 14-3-3 protein theta 14-3-3 protein zeta/delta 3-phosphoinositide-dependent protein kinase 1 M-phase inducer phosphatase Protein phosphatase 1 regulatory subunit 12A Protein phosphatase 1 regulatory subunit 14A Protein phosphatase 1 regulatory subunit Ras-related C3 botulinum toxin substrate 1 Rho-related GTP-binding protein RhoB Serine/threonine-protein kinase N1 Serine/threonine-protein kinase N2 Serine/threonine-protein phosphatase PP1-beta catalytic subunit Stratifin Transforming protein RhoA	D3ZIC4 D4ADT2 G3V9A3 O08874 O55173 P35213 P61589 P61983 P62142 P62260 P62747 P63102 P68255 P68511 Q10728 Q63433 Q6RUV5 Q99MC0	Arha Arha2 Arhb Cdc25c Cpi Cpi17 Mbs Msfs1 Mypt1 Pak2 Pdk1 Pdpk1 Pkn Pkn1 Pkn2 Ppp1cb Ppp1r12a Ppp1r12b Ppp1r14a Prk1 Prk2 Prkcl1 Prkcl2 Rac Rac1 Rhoa Rhob Sfn Ywhab Ywhae Ywhag Ywhah Ywhaq Ywhaz	Rattus norvegicus (Norway rat)
Phospholipase C-mediated cascade: FGFR1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 Fibroblast growth factor 10 Fibroblast growth factor 17 Fibroblast growth factor 1 Fibroblast growth factor 20 Fibroblast growth factor 23 Fibroblast growth factor 2 Fibroblast growth factor 5 Fibroblast growth factor 9 Fibroblast growth factor receptor 1 Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Klotho	A0A8I6B5D5 F1LSQ8 P10686 P13109 P36364 P48807 P61149 P63076 P70492 Q04589 Q8R5L5 Q8R5L9 Q8VI79 Q8VI82 Q9EST9 Q9Z2Y9	FGF22 FGF6 Fgf-1 Fgf-2 Fgf-5 Fgf-9 Fgf1 Fgf10 Fgf17 Fgf2 Fgf20 Fgf22 Fgf23 Fgf3 Fgf4 Fgf5 Fgf5c Fgf5d Fgf6 Fgf7a Fgf7b Fgf8 Fgf9 Fgfa Fgfr1 Flg Kl Plcg1	Rattus norvegicus (Norway rat)
Mitochondrial protein degradation	2-oxoglutarate dehydrogenase complex component E1 3-hydroxyacyl-CoA dehydrogenase type-2 3-oxoacyl-[acyl-carrier-protein] synthase, mitochondrial 5-aminolevulinate synthase, non-specific, mitochondrial 60 kDa heat shock protein, mitochondrial ADP/ATP translocase 2 AFG3 like matrix AAA peptidase subunit 2 ATP synthase subunit O, mitochondrial ATP synthase subunit a ATP synthase subunit alpha, mitochondrial ATP synthase subunit beta, mitochondrial ATP synthase subunit d, mitochondrial ATP synthase subunit g, mitochondrial ATP synthase subunit gamma, mitochondrial ATP synthase-coupling factor 6, mitochondrial ATP-dependent Clp protease ATP-binding subunit clpX-like, mitochondrial ATP-dependent Clp protease proteolytic subunit Acetyl-CoA acetyltransferase, mitochondrial Aconitate hydratase, mitochondrial Acyl-CoA dehydrogenase family, member 8 Acyl-CoA thioesterase 3 Acyl-CoA thioesterase 5 Acyl-coenzyme A thioesterase 1 Acyl-coenzyme A thioesterase 2, mitochondrial Aldehyde dehydrogenase X, mitochondrial Aldehyde dehydrogenase, mitochondrial Amyloid-beta precursor protein Arginase-2, mitochondrial Citrate synthase, mitochondrial Cytochrome b-c1 complex subunit 2, mitochondrial Cytochrome b-c1 complex subunit 8 Cytochrome c oxidase subunit 1 Cytochrome c oxidase subunit 5A, mitochondrial Cytochrome c oxidase subunit 5B, mitochondrial D-beta-hydroxybutyrate dehydrogenase, mitochondrial D-lactate dehydrogenase (cytochrome) Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial Delta-1-pyrroline-5-carboxylate synthase Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex Dihydrolipoyl dehydrogenase, mitochondrial Enoyl-CoA delta isomerase 1, mitochondrial Essential MCU regulator, mitochondrial Ferrochelatase Fumarate hydratase, mitochondrial Glutamate dehydrogenase 1, mitochondrial HtrA serine peptidase 2 Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial Hydroxymethylglutaryl-CoA synthase, mitochondrial Isocitrate dehydrogenase [NADP], mitochondrial Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial Large ribosomal subunit protein bL32m Lon protease homolog, mitochondrial Malate dehydrogenase, mitochondrial Malic enzyme Mitochondrial inner membrane m-AAA protease component paraplegin Mitochondrial ribosomal protein L12 Mitochondrial ribosomal protein S2 Mitochondrial-processing peptidase subunit alpha NAD kinase 2, mitochondrial NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial Propionyl-CoA carboxylase beta chain, mitochondrial Pyruvate dehydrogenase E1 component subunit alpha Pyruvate dehydrogenase E1 component subunit beta, mitochondrial Serine hydroxymethyltransferase Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial Single-stranded DNA-binding protein, mitochondrial Small ribosomal subunit protein uS10m Steroidogenic acute regulatory protein, mitochondrial Stress-70 protein, mitochondrial Succinate--CoA ligase [GDP-forming] subunit beta, mitochondrial Succinyl-CoA Transcription factor A, mitochondrial Twinkle mtDNA helicase [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial cAMP-dependent protein kinase catalytic subunit alpha isoleucine--tRNA ligase	A0A0G2K261 A0A0G2K502 A0A8I5ZKJ3 A0A8I5ZQL5 A0A8I6A6H9 A0A8I6AAN3 A0A8I6AIH6 A0A8I6ASM9 A0A8I6GEM4 A1A5R4 B0BNB9 B2GV06 B2GV15 D3ZA68 D3ZE15 D3ZG43 D3ZXF9 D3ZY44 D4A5G8 D4AEG6 F1LN92 F1LZC5 G3V6R7 M0RAD5 O08701 O55171 O70351 O88267 P04636 P05503 P05504 P07633 P08592 P10719 P10860 P11240 P11884 P12075 P13195 P14408 P15999 P17764 P20069 P21571 P22791 P23965 P27791 P28042 P29147 P31399 P32551 P35435 P48721 P49432 P56574 P63039 P70584 P97826 Q06647 Q09073 Q1HCL7 Q5U2U0 Q5U3Z7 Q5XI78 Q5XIH3 Q62651 Q63065 Q66HF1 Q66HF8 Q6P6R2 Q6PCU8 Q6PDU7 Q7TPJ4 Q7TQ16 Q7TQ82 Q7TT47 Q8VHF5 Q91ZW1 Q924S5 Q99NA5 Q9ER34 Q9WVK7	A4 AABR07056686.1 AC094055.1 AD1 Acad8 Acadsb Acat1 Aco2 Acot1 Acot2 Acot3 Acot5 Afg3l2 Alas1 Aldh18a1 Aldh1b1 Aldh2 Aldhx Ant2 App Arg2 Atp5a1 Atp5b Atp5c Atp5c1 Atp5f1a Atp5f1b Atp5f1c Atp5h Atp5j Atp5jd Atp5l Atp5mg Atp5o Atp5pd Atp5pf Atp5po Atp6 Atpase6 Bdh Bdh1 Clpp Clpx Coi Cox5a Cox5b Cs Cte1 Dbt Dci Dld Ech1 Eci1 Erab Fech Fh Fh1 Glud Glud1 Grp75 Had Hadh Hadh2 Hadhsc Hmgcs2 Hsd17b10 Hsp60 Hspa9 Hspa9a Hspd1 Htra2 Iars2 Idh2 Idh3a LOC100911483 Ldhd Lon Lonp1 Mdh2 Me2 Mnadk Mor1 Mppa Mrpl12 Mrpl32 Mrps10 Mrps2 Mt-atp6 Mt-co1 Mtatp6 Mtco1 Mte1 Nadk2 Nadkd1 Ndufa13 Ndufa2 Ndufs1 Ndufs3 Ndufv1 Ndufv3 Ogdh Ogdhl Oxct Oxct1 Oxsm Pccb Pdh Pdha1l1 Pdhb Pdk1 Peo1 Pmpca Prkaca Prss15 Qpc SUCLG2 Schad Scot Shmt2 Slc25a5 Smdt1 Spg7 Ssbp Ssbp1 Star Suclg2 Tfam Twnk Uqcrc2 Uqcrq	Rattus norvegicus (Norway rat)
LDL remodeling	Microsomal triglyceride transfer protein large subunit Protein disulfide-isomerase	D4A1W8 P04785	Mtp Mttp P4hb Pdia1	Rattus norvegicus (Norway rat)
ADP signalling through P2Y purinoceptor 1	Cytosolic phospholipase A2 Guanine nucleotide-binding protein G(q) subunit alpha Guanine nucleotide-binding protein subunit alpha-11 Guanine nucleotide-binding protein subunit alpha-15 Guanine nucleotide-binding protein subunit alpha Mitogen-activated protein kinase 14 P2Y purinoceptor 1 Proto-oncogene tyrosine-protein kinase Src	A0A8J8XRQ3 O88302 P49651 P50393 P70618 P82471 Q9JID2 Q9WUD9	Cpla2 Csbp1 Csbp2 Gna11 Gna14 Gna15 Gnaq Mapk14 P2ry1 Pla2g4 Pla2g4a Src	Rattus norvegicus (Norway rat)

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