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Lewy body dementia
Summary
- Synonym
-
- Dementia with Lewy bodies
- Diffuse Lewy body disease
- Lewy body disease
- Senile dementia of the Lewy body type
- Definition
- A dementia that is characterized by the development of abnormal proteinaceous (alpha-synuclein) cytoplasmic inclusions, called Lewy bodies, throughout the brain that results in progressive decline in mental abilities.
- Super Class
- dementia
Related Genes
| Gene ID | Gene Symbol | Description | Source |
|---|---|---|---|
| 2629 | GBA1 | glucosylceramidase beta 1 | |
| 3481 | IGF2 | insulin like growth factor 2 | |
| 3482 | IGF2R | insulin like growth factor 2 receptor | |
| 3612 | IMPA1 | inositol monophosphatase 1 | |
| 3958 | LGALS3 | galectin 3 | |
| 4099 | MAG | myelin associated glycoprotein | |
| 5111 | PCNA | proliferating cell nuclear antigen | |
| 5160 | PDHA1 | pyruvate dehydrogenase E1 subunit alpha 1 | |
| 5336 | PLCG2 | phospholipase C gamma 2 | |
| 5621 | PRNP | prion protein (Kanno blood group) |
Related Glycoprotein
| UniProt ID | Protein Name | Source |
|---|---|---|
| Q9NQ88 | Fructose-2,6-bisphosphatase TIGAR | |
| Q9P2R7 | Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial |
- The Human Phenotype Ontology
| HPO ID | HPO Term |
|---|---|
| HP:0001300 | Parkinsonism |
| HP:0000726 | Dementia |
| HP:0007159 | Fluctuations in consciousness |
| HP:0000006 | Autosomal dominant inheritance |
| HP:0002367 | Visual hallucination |
| HP:0100315 | Lewy bodies |
| HP:0000746 | Delusion |
