primary biliary cholangitis

Summary
Synonym
  • biliary liver cirrhosis
  • cholestatic cirrhosis
  • chronic nonsuppurative destructive cholangitis
  • primary biliary cirrhosis
Definition
A liver cirrhosis characterized by chronic and slow progressive destruction of intrahepatic bile ducts.
Super Class
autoimmune disease of gastrointestinal tract liver cirrhosis
Disease Ontology
DOID:12236
Mondo Disease Ontology
MeSH
UMLS
NCI Thesaurus
ORDO
OMIM
GARD
MGI genotype (from TogoID)
Related Genes
Displaying entries 21 - 30 of 54 in total
Gene ID Gene Symbol Description Source
3592 IL12A interleukin 12A
3594 IL12RB1 interleukin 12 receptor subunit beta 1
3875 KRT18 keratin 18
3930 LBR lamin B receptor
3952 LEP leptin
3953 LEPR leptin receptor
4142 MAS1 MAS1 proto-oncogene, G protein-coupled receptor
4313 MMP2 matrix metallopeptidase 2
4314 MMP3 matrix metallopeptidase 3
4318 MMP9 matrix metallopeptidase 9
Displaying entries 1 - 10 of 43 in total
Gene ID Gene Symbol Description Source
11303 Abca1 ATP-binding cassette, sub-family A member 1
11421 Ace angiotensin I converting enzyme
11829 Aqp4 aquaporin 4
12475 Cd14 CD14 antigen
12477 Ctla4 cytotoxic T-lymphocyte-associated protein 4
12496 Entpd2 ectonucleoside triphosphate diphosphohydrolase 2
12514 Cd68 CD68 antigen
12780 Abcc2 ATP-binding cassette, sub-family member 2
12842 Col1a1 collagen, type I, alpha 1
13138 Dag1 dystroglycan 1
Displaying entries 21 - 30 of 31 in total
Gene ID Gene Symbol Description Source
81686 Mmp2 matrix metallopeptidase 2
81687 Mmp9 matrix metallopeptidase 9
83516 Ppargc1a PPARG coactivator 1 alpha
83785 Vegfa vascular endothelial growth factor A
83840 Rps6kb1 ribosomal protein S6 kinase B1
84405 Il12a interleukin 12A
84511 Slco1c1 solute carrier organic anion transporter family, member 1c1
246097 Fas Fas cell surface death receptor
287287 Il4 interleukin 4
294853 Krt18 keratin 18
Displaying all 8 entries
Gene ID Gene Symbol Description Source
34189 Acer Angiotensin-converting enzyme-related
34805 Ance Angiotensin converting enzyme
34808 Ance-3 Ance-3
36428 Mdr49 Multi drug resistance 49
36773 Dg Dystroglycan
36830 Nup62 Nucleoporin 62kD
38726 Mdr65 Multi drug resistance 65
39954 Oatp74D Organic anion transporting polypeptide 74D
Displaying all 3 entries
Gene ID Gene Symbol Description Source
30682 vegfaa vascular endothelial growth factor Aa
492331 ace2 angiotensin I converting enzyme 2
565980 ace angiotensin I converting enzyme (peptidyl-dipeptidase A) 1
Displaying 1 entry
Gene ID Gene Symbol Description Source Organism
100144634 ace angiotensin I converting enzyme Xenopus tropicalis (tropical clawed frog)
Displaying entry 11 - 11 of 11 in total
Gene ID Gene Symbol Description Source
181326 pgp-3 Multidrug resistance protein pgp-3
Displaying all 5 entries
Gene ID Gene Symbol Description Source
850645 BPT1 ATP-binding cassette bilirubin transporter BPT1
852092 PHO8 alkaline phosphatase PHO8
853409 NSP1 FG-nucleoporin NSP1
853671 STE6 ATP-binding cassette a-factor transporter STE6
855949 PEP4 proteinase A

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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01


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Last updated: December 9, 2024