primary biliary cholangitis

Summary
Synonym
  • biliary liver cirrhosis
  • cholestatic cirrhosis
  • chronic nonsuppurative destructive cholangitis
  • primary biliary cirrhosis
Definition
A liver cirrhosis characterized by chronic and slow progressive destruction of intrahepatic bile ducts.
Super Class
autoimmune disease of gastrointestinal tract liver cirrhosis
Disease Ontology
DOID:12236
Mondo Disease Ontology
MeSH
UMLS
NCI Thesaurus
ORDO
OMIM
GARD
MGI genotype (from TogoID)
Related Genes
Displaying entries 1 - 10 of 54 in total
Gene ID Gene Symbol Description Source
19 ABCA1 ATP binding cassette subfamily A member 1
183 AGT angiotensinogen
355 FAS Fas cell surface death receptor
361 AQP4 aquaporin 4
929 CD14 CD14 molecule
954 ENTPD2 ectonucleoside triphosphate diphosphohydrolase 2
968 CD68 CD68 molecule
1244 ABCC2 ATP binding cassette subfamily C member 2
1277 COL1A1 collagen type I alpha 1 chain
1490 CCN2 cellular communication network factor 2
Displaying entries 41 - 43 of 43 in total
Gene ID Gene Symbol Description Source
72508 Rps6kb1 ribosomal protein S6 kinase, polypeptide 1
81897 Tlr9 toll-like receptor 9
98386 Lbr lamin B receptor
Displaying entries 21 - 30 of 31 in total
Gene ID Gene Symbol Description Source
81686 Mmp2 matrix metallopeptidase 2
81687 Mmp9 matrix metallopeptidase 9
83516 Ppargc1a PPARG coactivator 1 alpha
83785 Vegfa vascular endothelial growth factor A
83840 Rps6kb1 ribosomal protein S6 kinase B1
84405 Il12a interleukin 12A
84511 Slco1c1 solute carrier organic anion transporter family, member 1c1
246097 Fas Fas cell surface death receptor
287287 Il4 interleukin 4
294853 Krt18 keratin 18
Displaying all 8 entries
Gene ID Gene Symbol Description Source
34189 Acer Angiotensin-converting enzyme-related
34805 Ance Angiotensin converting enzyme
34808 Ance-3 Ance-3
36428 Mdr49 Multi drug resistance 49
36773 Dg Dystroglycan
36830 Nup62 Nucleoporin 62kD
38726 Mdr65 Multi drug resistance 65
39954 Oatp74D Organic anion transporting polypeptide 74D
Displaying all 3 entries
Gene ID Gene Symbol Description Source
30682 vegfaa vascular endothelial growth factor Aa
492331 ace2 angiotensin I converting enzyme 2
565980 ace angiotensin I converting enzyme (peptidyl-dipeptidase A) 1
Displaying 1 entry
Gene ID Gene Symbol Description Source Organism
100144634 ace angiotensin I converting enzyme Xenopus tropicalis (tropical clawed frog)
Displaying entry 11 - 11 of 11 in total
Gene ID Gene Symbol Description Source
181326 pgp-3 Multidrug resistance protein pgp-3
Displaying all 5 entries
Gene ID Gene Symbol Description Source
850645 BPT1 ATP-binding cassette bilirubin transporter BPT1
852092 PHO8 alkaline phosphatase PHO8
853409 NSP1 FG-nucleoporin NSP1
853671 STE6 ATP-binding cassette a-factor transporter STE6
855949 PEP4 proteinase A

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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01


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Last updated: December 9, 2024