acute chest syndrome

Summary
Synonym
  • acute chest syndrome in sickle cell disease
Definition
A lung disease that involves a vasoocclusive crisis of the pulmonary vasculature seen in patients with sickle cell anemia. The crisis is initiated by a lung infection, and the resulting inflammation and loss of oxygen tension leads to sickling of red cells and further vasoocclusion. The disease has_symptom fever, has_symptom pleuritic chest pain, has_symptom tachypnea, has_symptom cough, has_symptom hypoxemia, has_symptom marked leukocytosis, and has_symptom diffuse infiltrates on chest radiograph.
Super Class
lung disease
Disease Ontology
DOID:1584
Mondo Disease Ontology
MeSH
UMLS
NCI Thesaurus
Related Genes
Displaying all 3 entries
Gene ID Gene Symbol Description Source
3043 HBB hemoglobin subunit beta
4846 NOS3 nitric oxide synthase 3
7422 VEGFA vascular endothelial growth factor A
Displaying all 2 entries
Gene ID Gene Symbol Description Source
18127 Nos3 nitric oxide synthase 3, endothelial cell
22339 Vegfa vascular endothelial growth factor A
Displaying all 2 entries
Gene ID Gene Symbol Description Source
24600 Nos3 nitric oxide synthase 3
83785 Vegfa vascular endothelial growth factor A
Displaying 1 entry
Gene ID Gene Symbol Description Source
30682 vegfaa vascular endothelial growth factor Aa

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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01


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Last updated: December 9, 2024