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acute chest syndrome
Summary
- Synonym
-
- acute chest syndrome in sickle cell disease
- Definition
- A lung disease that involves a vasoocclusive crisis of the pulmonary vasculature seen in patients with sickle cell anemia. The crisis is initiated by a lung infection, and the resulting inflammation and loss of oxygen tension leads to sickling of red cells and further vasoocclusion. The disease has_symptom fever, has_symptom pleuritic chest pain, has_symptom tachypnea, has_symptom cough, has_symptom hypoxemia, has_symptom marked leukocytosis, and has_symptom diffuse infiltrates on chest radiograph.
- Super Class
- lung disease
External Links
- Disease Ontology
- DOID:1584
- Mondo Disease Ontology
- MeSH
- UMLS
- NCI Thesaurus
Related Genes
| Gene ID | Gene Symbol | Description | Source |
|---|---|---|---|
| 5321 | PLA2G4A | phospholipase A2 group IVA | |
| 5332 | PLCB4 | phospholipase C beta 4 | |
| 5742 | PTGS1 | prostaglandin-endoperoxide synthase 1 | |
| 5743 | PTGS2 | prostaglandin-endoperoxide synthase 2 | |
| 6401 | SELE | selectin E | |
| 6402 | SELL | selectin L | |
| 6403 | SELP | selectin P | |
| 7412 | VCAM1 | vascular cell adhesion molecule 1 | |
| 7941 | PLA2G7 | phospholipase A2 group VII | |
| 8398 | PLA2G6 | phospholipase A2 group VI |
Related Glycoprotein
| UniProt ID | Protein Name | Source |
|---|---|---|
| P14151 | L-selectin | |
| P14555 | Phospholipase A2, membrane associated | |
| P15289 | Arylsulfatase A | |
| P16070 | CD44 antigen | |
| P16109 | P-selectin | |
| P16442 | Histo-blood group ABO system transferase | |
| P16581 | E-selectin | |
| P17931 | Galectin-3 | |
| P19320 | Vascular cell adhesion protein 1 | |
| P20815 | Cytochrome P450 3A5 |
