Langerhans-cell histiocytosis

Summary
Synonym
  • Histiocytosis X
  • Langerhan's cell histiocytosis
  • Langerhans cell granulomatosis
  • Letterer-Siwe disease
  • Letterer-Siwe disease involving intra-abdominal lymph nodes
  • Letterer-Siwe disease involving intrapelvic lymph nodes
  • Letterer-Siwe disease involving intrathoracic lymph nodes
  • Letterer-Siwe disease involving lymph nodes of axilla and upper limb
  • Letterer-Siwe disease involving lymph nodes of head, face and neck
  • Letterer-Siwe disease involving lymph nodes of head, face, and neck
  • Letterer-Siwe disease involving lymph nodes of inguinal region and lower limb
  • Letterer-Siwe disease involving lymph nodes of multiple sites
  • Letterer-Siwe disease involving spleen
  • Letterer-Siwe disease of intra-abdominal lymph nodes
  • Letterer-Siwe disease of intrapelvic lymph nodes
  • Letterer-Siwe disease of intrathoracic lymph nodes
  • Letterer-Siwe disease of lymph nodes of axilla and upper limb
  • Letterer-Siwe disease of lymph nodes of axilla and/or upper limb
  • Letterer-Siwe disease of lymph nodes of head, face and neck
  • Letterer-Siwe disease of lymph nodes of head, face and/or neck
  • Letterer-Siwe disease of lymph nodes of inguinal region amd/or lower limb
  • Letterer-Siwe disease of lymph nodes of inguinal region and lower limb
  • Letterer-Siwe disease of lymph nodes of inguinal region and/or lower limb
  • Letterer-Siwe disease of lymph nodes of multiple sites
  • Letterer-Siwe disease of spleen
Definition
A histiocytosis that is characterized by clonal proliferation of Langerhans cells.
Super Class
histiocytosis
External Links
Disease Ontology
DOID:2571
Mondo Disease Ontology
MeSH
UMLS
NCI Thesaurus
OMIM
MGI genotype (from TogoID)
Related Genes
Displaying entries 41 - 50 of 71 in total
Gene ID Gene Symbol Description Source
4684 NCAM1 neural cell adhesion molecule 1
4913 NTHL1 nth like DNA glycosylase 1
4968 OGG1 8-oxoguanine DNA glycosylase
5048 PAFAH1B1 platelet activating factor acetylhydrolase 1b regulatory subunit 1
5091 PC pyruvate carboxylase
5290 PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha
5291 PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta
5293 PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta
5294 PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma
5728 PTEN phosphatase and tensin homolog
Displaying 1 entry
Gene ID Gene Symbol Description Source
109880 Braf Braf transforming gene

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Acknowledgements

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Partly supported by NIH Common Fund Grant #1U01GM125267-01


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Last updated: August 19, 2024