chronic obstructive pulmonary disease

Summary
Synonym
  • COLD
  • COPD
  • chronic obstructive airway disease
  • chronic obstructive lung disease
Definition
An obstructive lung disease that is a chronic and progressive disorder of small airways in the lungs and that is characterized by irreversible airflow obstruction, typically identified by reductions in quantitative spirometric indices, induced forced expiratory volume at 1 second (FEV1) and the ratio of FEV1 to forced vital capacity (less than 0.7 is diagnostic of COPD). Lung volume is increased and pulmonary hypertension may occur. The pathologic changes result in the disruption of the airflow in the bronchial airways. Signs and symptoms include shortness of breath, wheezing, productive cough and chest tightness. COPD is a consequence (an end result) of chronic bronchitis, emphysema or both.
Super Class
obstructive lung disease
Disease Ontology
DOID:3083
Mondo Disease Ontology
MeSH
UMLS
NCI Thesaurus
OMIM
MGI genotype (from TogoID)
Related Genes
Displaying entries 101 - 110 of 126 in total
Gene ID Gene Symbol Description Source
6532 SLC6A4 solute carrier family 6 member 4
6649 SOD3 superoxide dismutase 3
6772 STAT1 signal transducer and activator of transcription 1
6775 STAT4 signal transducer and activator of transcription 4
7040 TGFB1 transforming growth factor beta 1
7076 TIMP1 TIMP metallopeptidase inhibitor 1
7099 TLR4 toll like receptor 4
7124 TNF tumor necrosis factor
7132 TNFRSF1A TNF receptor superfamily member 1A
7133 TNFRSF1B TNF receptor superfamily member 1B
Displaying entries 1 - 10 of 123 in total
Gene ID Gene Symbol Description Source
11421 Ace angiotensin I converting enzyme
11441 Chrna7 cholinergic receptor, nicotinic, alpha polypeptide 7
11450 Adipoq adiponectin, C1Q and collagen domain containing
11502 Adam9 ADAM metallopeptidase domain 9
11554 Adrb1 adrenergic receptor, beta 1
11555 Adrb2 adrenergic receptor, beta 2
11596 Ager advanced glycosylation end product-specific receptor
12062 Bdkrb2 bradykinin receptor, beta 2
12176 Bnip3 BCL2/adenovirus E1B interacting protein 3
12266 C3 complement component 3
Displaying entries 21 - 30 of 68 in total
Gene ID Gene Symbol Description Source
25245 Bdkrb2 bradykinin receptor B2
25302 Chrna7 cholinergic receptor nicotinic alpha 7 subunit
25350 Sftpd surfactant protein D
25352 Sod3 superoxide dismutase 3
25385 Faslg Fas ligand
25419 Crp C-reactive protein
25464 Icam1 intercellular adhesion molecule 1
25553 Slc6a4 solute carrier family 6 member 4
25556 Il1rl1 interleukin 1 receptor-like 1
25589 Kdr kinase insert domain receptor
Displaying entries 1 - 10 of 21 in total
Gene ID Gene Symbol Description Source
31926 Idgf4 Imaginal disc growth factor 4
34091 Spn28Dc Serpin 28Dc
34189 Acer Angiotensin-converting enzyme-related
34304 nAChRalpha6 nicotinic Acetylcholine Receptor alpha6
34805 Ance Angiotensin converting enzyme
34978 Idgf1 Imaginal disc growth factor 1
34979 Idgf2 Imaginal disc growth factor 2
34981 Idgf3 Imaginal disc growth factor 3
36868 Idgf6 Imaginal disc growth factor 6
37104 Idgf5 Imaginal disc growth factor 5
Displaying all 6 entries
Gene ID Gene Symbol Description Source
30682 vegfaa vascular endothelial growth factor Aa
447803 pon1 paraoxonase 1
554230 kdr kinase insert domain receptor (a type III receptor tyrosine kinase)
559080 cftr CF transmembrane conductance regulator
565980 ace angiotensin I converting enzyme (peptidyl-dipeptidase A) 1
791973 cxcr3.2 chemokine (C-X-C motif) receptor 3, tandem duplicate 2
Displaying all 6 entries
Gene ID Gene Symbol Description Source Organism
373580 crhr1.2.S corticotropin releasing hormone receptor 1, gene 2 S homeolog Xenopus laevis (African clawed frog)
397778 tgfb1.L transforming growth factor beta 1 L homeolog Xenopus laevis (African clawed frog)
399298 ntf3.L neurotrophin 3 L homeolog Xenopus laevis (African clawed frog)
448598 pon2 paraoxonase 2 Xenopus tropicalis (tropical clawed frog)
100144634 ace angiotensin I converting enzyme Xenopus tropicalis (tropical clawed frog)
108697308 adrb1.L adrenoceptor beta 1 L homeolog Xenopus laevis (African clawed frog)
Displaying entries 11 - 20 of 33 in total
Gene ID Gene Symbol Description Source
178269 lev-1 Acetylcholine receptor subunit beta-type lev-1
178672 srp-3 Serpin domain-containing protein
179197 cri-2 Putative metalloproteinase inhibitor tag-225
179235 acr-16 Acetylcholine receptor subunit alpha-type acr-16
179962 gar-3 Muscarinic acetylcholine receptor gar-3
179991 zmp-4 Hemopexin;Peptidase metallopeptidase domain-containing protein
180289 mrp-7 Multidrug resistance protein mrp-7
180351 W01F3.2 Uncharacterized protein
180408 mrp-2 Multidrug resistance-associated protein 1
180409 mrp-1 Multidrug resistance-associated protein 1
Displaying all 3 entries
Gene ID Gene Symbol Description Source
851977 CTS2 putative chitinase
853313 PBS2 mitogen-activated protein kinase kinase PBS2
853978 NFT1 putative multidrug transporter NFT1

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