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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
myelofibrosis
Summary
- Synonym
-
- Agnogenic myeloid metaplasia
- Aleukemic myelosis
- Megakaryocytic myelosclerosis
- bone Marrow Fibrosis
- myelosclerosis
- primary myelofibrosis
- Definition
- A myeloid neoplasm that is located in the bone marrow which results in bone marrow being replaced by fibrous (scar) tissue.
- Super Class
- myeloid neoplasm
Related Genes
| Gene ID | Gene Symbol | Description | Source |
|---|---|---|---|
| 2539 | G6PD | glucose-6-phosphate dehydrogenase | |
| 3417 | IDH1 | isocitrate dehydrogenase (NADP(+)) 1 | |
| 3418 | IDH2 | isocitrate dehydrogenase (NADP(+)) 2 | |
| 3939 | LDHA | lactate dehydrogenase A | |
| 3945 | LDHB | lactate dehydrogenase B | |
| 3956 | LGALS1 | galectin 1 | |
| 3958 | LGALS3 | galectin 3 | |
| 4680 | CEACAM6 | CEA cell adhesion molecule 6 | |
| 5290 | PIK3CA | phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha | |
| 5291 | PIK3CB | phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta |
Related Glycoprotein
| UniProt ID | Protein Name | Source |
|---|---|---|
| P11413 | Glucose-6-phosphate 1-dehydrogenase | |
| P12821 | Angiotensin-converting enzyme | |
| P13727 | Bone marrow proteoglycan | |
| P16109 | P-selectin | |
| P17931 | Galectin-3 | |
| P24557 | Thromboxane-A synthase | |
| P27797 | Calreticulin | |
| P35610 | Sterol O-acyltransferase 1 | |
| P36222 | Chitinase-3-like protein 1 | |
| P40199 | Carcinoembryonic antigen-related cell adhesion molecule 6 |
- The Human Phenotype Ontology
| HPO ID | HPO Term |
|---|---|
| HP:0001892 | Abnormal bleeding |
| HP:0000980 | Pallor |
| HP:0002240 | Hepatomegaly |
| HP:0012143 | Abnormal megakaryocyte morphology |
| HP:0001978 | Extramedullary hematopoiesis |
| HP:0001873 | Thrombocytopenia |
| HP:0004447 | Poikilocytosis |
| HP:0001409 | Portal hypertension |
| HP:0003388 | Easy fatigability |
| HP:0001903 | Anemia |
