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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
myelofibrosis
Summary
- Synonym
-
- Agnogenic myeloid metaplasia
- Aleukemic myelosis
- Megakaryocytic myelosclerosis
- bone Marrow Fibrosis
- myelosclerosis
- primary myelofibrosis
- Definition
- A myeloid neoplasm that is located in the bone marrow which results in bone marrow being replaced by fibrous (scar) tissue.
- Super Class
- myeloid neoplasm
Related Genes
| Gene ID | Gene Symbol | Description | Source |
|---|---|---|---|
| 248 | ALPI | alkaline phosphatase, intestinal | |
| 250 | ALPP | alkaline phosphatase, placental | |
| 412 | STS | steroid sulfatase | |
| 811 | CALR | calreticulin | |
| 847 | CAT | catalase | |
| 1048 | CEACAM5 | CEA cell adhesion molecule 5 | |
| 1109 | AKR1C4 | aldo-keto reductase family 1 member C4 | |
| 1116 | CHI3L1 | chitinase 3 like 1 | |
| 1118 | CHIT1 | chitinase 1 | |
| 1636 | ACE | angiotensin I converting enzyme |
Related Glycoprotein
| UniProt ID | Protein Name | Source |
|---|---|---|
| P42338 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | |
| P48735 | Isocitrate dehydrogenase [NADP], mitochondrial | |
| P48736 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | |
| Q13231 | Chitotriosidase-1 | |
| Q13478 | Interleukin-18 receptor 1 | |
| Q5H8C1 | FRAS1-related extracellular matrix protein 1 | |
| Q8N6Q3 | CD177 antigen |
- The Human Phenotype Ontology
| HPO ID | HPO Term |
|---|---|
| HP:0001892 | Abnormal bleeding |
| HP:0000980 | Pallor |
| HP:0002240 | Hepatomegaly |
| HP:0012143 | Abnormal megakaryocyte morphology |
| HP:0001978 | Extramedullary hematopoiesis |
| HP:0001873 | Thrombocytopenia |
| HP:0004447 | Poikilocytosis |
| HP:0001409 | Portal hypertension |
| HP:0003388 | Easy fatigability |
| HP:0001903 | Anemia |
