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myelofibrosis
Summary
- Synonym
-
- Agnogenic myeloid metaplasia
- Aleukemic myelosis
- Megakaryocytic myelosclerosis
- bone Marrow Fibrosis
- myelosclerosis
- primary myelofibrosis
- Definition
- A myeloid neoplasm that is located in the bone marrow which results in bone marrow being replaced by fibrous (scar) tissue.
- Super Class
- myeloid neoplasm
Related Genes
| Gene ID | Gene Symbol | Description | Source |
|---|---|---|---|
| 811 | CALR | calreticulin | |
| 998 | CDC42 | cell division cycle 42 | |
| 2146 | EZH2 | enhancer of zeste 2 polycomb repressive complex 2 subunit | |
| 2322 | FLT3 | fms related receptor tyrosine kinase 3 | |
| 2323 | FLT3LG | fms related receptor tyrosine kinase 3 ligand | |
| 3077 | HFE | homeostatic iron regulator | |
| 4297 | KMT2A | lysine methyltransferase 2A | |
| 4352 | MPL | MPL proto-oncogene, thrombopoietin receptor | |
| 7040 | TGFB1 | transforming growth factor beta 1 | |
| 7157 | TP53 | tumor protein p53 |
| Gene ID | Gene Symbol | Description | Source |
|---|---|---|---|
| 12317 | Calr | calreticulin | |
| 14056 | Ezh2 | enhancer of zeste 2 polycomb repressive complex 2 subunit | |
| 14255 | Flt3 | FMS-like tyrosine kinase 3 | |
| 14256 | Flt3l | FMS-like tyrosine kinase 3 ligand | |
| 15216 | Hfe | homeostatic iron regulator | |
| 17480 | Mpl | myeloproliferative leukemia virus oncogene | |
| 17863 | Myb | myeloblastosis oncogene | |
| 20602 | Ncor2 | nuclear receptor co-repressor 2 | |
| 21803 | Tgfb1 | transforming growth factor, beta 1 | |
| 22059 | Trp53 | transformation related protein 53 |
- The Human Phenotype Ontology
| HPO ID | HPO Term |
|---|---|
| HP:0001892 | Abnormal bleeding |
| HP:0000980 | Pallor |
| HP:0002240 | Hepatomegaly |
| HP:0012143 | Abnormal megakaryocyte morphology |
| HP:0001978 | Extramedullary hematopoiesis |
| HP:0001873 | Thrombocytopenia |
| HP:0004447 | Poikilocytosis |
| HP:0001409 | Portal hypertension |
| HP:0003388 | Easy fatigability |
| HP:0001903 | Anemia |
