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ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 2

Summary

Gene Symbol

ST6GALNAC2

Aliases

ST6GalNAII
STHM

Organism

Homo sapiens (human)

External Links

NCBI Gene

10610

GGDB ID

gg057

HGNC

10867

mRNA

NM_006456

map

17q25.1

Protein

NP_006447

OMIM

610137

KEGG Gene ID

hsa:10610

PubChem

10610

Alliance of Genome Resources

HGNC:10867

Annotation

Keyword

3D-structure
Disulfide bond
Glycoprotein
Glycosyltransferase
Golgi apparatus
Reference proteome
Signal-anchor
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
Q9UJ37	GalNAc alpha-2,6-sialyltransferase II ST6GalNAc II SThM Sialyltransferase 7B

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
protein glycosylation	IDA	29251719
protein O-linked glycosylation	IDA	10742600
protein O-linked glycosylation	IBA
O-glycan processing	TAS
viral protein processing	TAS

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation

protein O-linked glycosylation

O-glycan processing

protein sialylation

primary metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation

protein O-linked glycosylation

O-glycan processing

protein sialylation

glycosylation [inference]

macromolecule glycosylation [inference]

protein glycosylation

protein O-linked glycosylation

O-glycan processing

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation

protein O-linked glycosylation

O-glycan processing

protein sialylation

macromolecule modification [inference]

protein modification process [inference]

protein glycosylation

protein O-linked glycosylation

O-glycan processing

protein sialylation

macromolecule glycosylation [inference]

protein glycosylation

protein O-linked glycosylation

O-glycan processing

sialylation [inference]

protein sialylation

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation

protein O-linked glycosylation

O-glycan processing

protein sialylation

viral process [inference]

viral protein processing

Displaying 1 entry
GO Term	Evidence Code	PMID
Golgi membrane	TAS

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

organelle membrane [inference]

bounding membrane of organelle [inference]

Golgi membrane

Displaying **all 4** entries
GO Term	Evidence Code	PMID
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity	TAS
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity	IDA	10742600 29251719
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity	IBA
sialyltransferase activity	TAS

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

glycosyltransferase activity [inference]

sialyltransferase activity

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Sialyltransferase

Functional Category

H: Coenzyme transport and metabolism
M: Cell wall/membrane/envelope biogenesis
T: Signal transduction mechanisms

Displaying **all 2** entries
Gene Ontology
sialyltransferase activity
transferase activity

Displaying **all 2** entries
InterPro
GT29-like superfamiliy
Glycosyl transferase family 29

GlycoGene Database (GGDB)

GGDB ID

gg057

Gene Symbol

ST6GALNAC2

Reactions

Displaying **all 2** entries
Donor	Acceptor	Reducing terminal(Acceptor)	Product	Reducing terminal(Product)	Reference
CMP-Neu5Ac	G00031MO	Ser/Thr	G56682BC	Ser/Thr	10742600
CMP-Neu5Ac	G65562ZE	Ser/Thr	G01614ZM	Ser/Thr	10742600

Displaying **all 2** entries
Donor	Acceptor	Reducing terminal(Acceptor)	Product	Reducing terminal(Product)	Reference
CMP-Neu5Ac	G00031MO	Ser/Thr	G56682BC	Ser/Thr	10536037 10742600
CMP-Neu5Ac	G65562ZE	Ser/Thr	G01614ZM	Ser/Thr	10536037 10742600

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Donor	Acceptor	Reducing terminal(Acceptor)	Reference
CMP-Neu5Ac	G49108TO	benzyl	11062056
CMP-Neu5Ac	G00056MO	octyl	10742600
CMP-Neu5Ac	G46677TE	ceramide	11062056
CMP-Neu5Ac	G57321FI	Ser/Thr	10536037
CMP-Neu5Ac	G05212BT		11062056

Orthologous Gene

Displaying **all 2** entries
Species	Protein	mRNA
Rattus norvegicus	XP_221134	XM_221134
Mus musculus	NP_033206	NM_009180

KEGG BRITE Database

Orthology

K06616

Name

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase (sialyltransferase 7B) [EC:2.4.3.3]

References

10742600

Reactions

Displaying **all 2** entries
KEGG Reaction	Enzyme	Acceptor	Product
R12704	2.4.3.3	G00031MO	G28694FA
R05914	2.4.3.3 2.4.3.7	G65562ZE	G01614ZM

Rhea

RHEA:11136

a β-D-galactosyl-(1→3)-N-acetyl-α-D-galactosaminyl derivative + CMP-N-acetyl-β-neuraminate

a β-D-galactosyl-(1→3)-[N-acetyl-α-neuraminyl-(2→6)]-N-acetyl-α-D-galactosaminyl derivative + H⁺ + CMP

Enzyme

2.4.3.3

PMID

Ortholog

Displaying entries **1 - 10** of 58 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Xenopus tropicalis	10610	Xenbase:XB-GENE-961127
Mus musculus	20446	Xenbase:XB-GENE-961127	MOUSE03979
Rattus norvegicus	303692	Xenbase:XB-GENE-961127	RATNO01414
Xenopus tropicalis	395053	Xenbase:XB-GENE-961127
Danio rerio	407706	ZFIN:ZDB-GENE-050309-58
Pan troglodytes	449513		PANTR15504
Macaca mulatta	707237		MACMU15760
Xenopus tropicalis	100001225	Xenbase:XB-GENE-961127
Monodelphis domestica	100026506		MONDO10452
Ornithorhynchus anatinus	100087307		ORNAN00243

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

Search Tools

Guidelines

Summary

External Links

Annotation

OrthoDB (Group)

GlycoGene Database (GGDB)

KEGG BRITE Database

International Collaboration

Acknowledgements