GLYCAM

Neup5Aca2-3DGalpb1-3[Neup5Aca2-6]DGalpNAca1-OH

• General Reaction
• Substrate Transferred

Displaying all 5 entries

Gene Symbol	Donor	Acceptor	Reducing terminal(Acceptor)	Product	Reducing terminal(Product)	Reference
ST6GALNAC3	CMP-Neu5Ac	G65562ZE	Ser/Thr	G01614ZM	Ser/Thr	16169874
ST6GALNAC4	CMP-Neu5Ac	G65562ZE	R	G01614ZM	R	11062056
ST6GALNAC4	CMP-Neu5Ac	G65562ZE	Ser/Thr	G01614ZM	Ser/Thr	11062056
ST6GALNAC2	CMP-Neu5Ac	G65562ZE	Ser/Thr	G01614ZM	Ser/Thr	10742600
ST6GALNAC1	CMP-Neu5Ac	G65562ZE	Ser/Thr	G01614ZM	Ser/Thr	10536037

Displaying entries 1 - 5 of 6 in total

Gene Symbol	Donor	Acceptor	Reducing terminal(Acceptor)	Product	Reducing terminal(Product)	Reference
ST6GALNAC3	CMP-Neu5Ac	G65562ZE	Ser/Thr	G01614ZM	Ser/Thr	10536037 16169874
ST6GALNAC4	CMP-Neu5Ac	G65562ZE	R	G01614ZM	R	11062056
ST6GALNAC4	CMP-Neu5Ac	G65562ZE	Ser/Thr	G01614ZM	Ser/Thr	11062056
ST6GALNAC2	CMP-Neu5Ac	G65562ZE	Ser/Thr	G01614ZM	Ser/Thr	10536037 10742600
ST6GALNAC4	CMP-Neu5Ac	G65562ZE	benzyl	G01614ZM	benzyl	11062056

KEGG ID

• G00027

Enzyme

• 2.4.3.3
• 2.4.3.7

References

• 14631106
• 7509790

Reactions

Epitope ID

EP0023

Epitope Name

Disialyl T Antigen

Tissues in which this glycan is expressed are highlighted in yellow.

GlycoCT

RES
1b:a-dgal-HEX-1:5
2s:n-acetyl
3b:b-dgal-HEX-1:5
4b:a-dgro-dgal-NON-2:6|1:a|2:keto|3:d
5s:n-acetyl
6b:a-dgro-dgal-NON-2:6|1:a|2:keto|3:d
7s:n-acetyl
LIN
1:1d(2+1)2n
2:1o(3+1)3d
3:3o(3+2)4d
4:4d(5+1)5n
5:1o(6+2)6d
6:6d(5+1)7n

WURCS

WURCS=2.0/3,4,3/[a2112h-1a_1-5_2*NCC/3=O][a2112h-1b_1-5][Aad21122h-2a_2-6_5*NCC/3=O]/1-2-3-3/a3-b1_a6-d2_b3-c2

GlycoEpitope

• Yu SY et al. Identification of blood group A/A-Leb/y and B/B-Leb/y active glycotopes co-expressed on the O-glycans isolated from two distinct human ovarian cyst fluids. Proteomics. 2009 Jul;9:(13):3445-62. doi: 10.1002/pmic.200800870. PMID: 19609959.

• Muroi K et al. Expression of sialosyl-T and disialosyl-T antigens in erythroid cells. Leuk Lymphoma. 1997 May;25:(5-6):403-14. doi: 10.3109/10428199709039027. PMID: 9250810.

• Vyas AA et al. Potent glycan inhibitors of myelin-associated glycoprotein enhance axon outgrowth in vitro. J Biol Chem. 2005 Apr 22;280:(16):16305-10. doi: 10.1074/jbc.M500250200. PMID: 15701648.

• van Schooten CJ et al. Variations in glycosylation of von Willebrand factor with O-linked sialylated T antigen are associated with its plasma levels. Blood. 2007 Mar 15;109:(6):2430-7. doi: 10.1182/blood-2006-06-032706. PMID: 17090649.

• Saito S et al. Common tetrasaccharide epitope NeuAc alpha 2-->3Gal beta 1-->3(Neu-Ac alpha 2-->6)GalNAc, presented by different carrier glycosylceramides or O-linked peptides, is recognized by different antibodies and ligands having distinct specificities. J Biol Chem. 1994 Feb 25;269:(8):5644-52. PMID: 7509790.