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G01614ZM

Summary
GlyTouCan ID
G01614ZM
IUPAC Condensed
Neu5Ac(a2-3)Gal(b1-3)[Neu5Ac(a2-6)]GalNAc(a1-
Motifs
Di-sialyl T antigen
Subsumption Level
Fully-defined saccharide
Monoisotopic Mass
965.33
GlyConnect structure
GlyGen
ChEBI
PubChem Compound
PubChem Substance
CarbBank
600 601 602 604 605 606 607 608 3657 3749 4200 4457 5161 5215 7941 7942 7951 8011 8012 8013 8014 8015 8016 8017 8018 8019 13281 13571 18996 21557 21898 22442 22747 22750 22770 23361 24978 29113 30507 32227 32428 32429 35081 35742 35990 42351 44021 45096 46409
3D Structures
GLYCAM
Neup5Aca2-3DGalpb1-3[Neup5Aca2-6]DGalpNAca1-OH
GlycoShape
G01614ZM
Displaying 1 entry
Archetype α β
G30110UW
G01614ZM
G04267XF
Organisms
Displaying entries 1 - 5 of 8 in total
Organisms Evidence
Mus musculus (house mouse)
Canis lupus familiaris (dog)
Danio rerio (zebrafish)
Friend murine leukemia virus
Rattus norvegicus (Norway rat)
Taxonomic Hierarchy
GlycoGene Database (GGDB)
Displaying all 5 entries
Gene Symbol Donor Acceptor Reducing terminal(Acceptor) Product Reducing terminal(Product) Reference
ST6GALNAC4 CMP-Neu5Ac
G65562ZE
Ser/Thr
G01614ZM
Ser/Thr
ST6GALNAC4 CMP-Neu5Ac
G65562ZE
R
G01614ZM
R
ST6GALNAC2 CMP-Neu5Ac
G65562ZE
Ser/Thr
G01614ZM
Ser/Thr
ST6GALNAC3 CMP-Neu5Ac
G65562ZE
Ser/Thr
G01614ZM
Ser/Thr
ST6GALNAC1 CMP-Neu5Ac
G65562ZE
Ser/Thr
G01614ZM
Ser/Thr
Displaying entries 1 - 5 of 6 in total
Gene Symbol Donor Acceptor Reducing terminal(Acceptor) Product Reducing terminal(Product) Reference
ST6GALNAC4 CMP-Neu5Ac
G65562ZE
Ser/Thr
G01614ZM
Ser/Thr
ST6GALNAC4 CMP-Neu5Ac
G65562ZE
R
G01614ZM
R
ST6GALNAC2 CMP-Neu5Ac
G65562ZE
Ser/Thr
G01614ZM
Ser/Thr
ST6GALNAC4 CMP-Neu5Ac
G65562ZE
benzyl
G01614ZM
benzyl
ST6GALNAC3 CMP-Neu5Ac
G65562ZE
Ser/Thr
G01614ZM
Ser/Thr
KEGG BRITE Database
KEGG ID
Enzyme
References
Reactions
Displaying 1 entry
KEGG Reaction Enzyme Acceptor Product
R05914
Core Protein
Displaying entries 1 - 10 of 40 in total
UniProt ID Protein Name Reference Source
B8Q179 Glycophorin B Miltenberger subtype III
P00743 Coagulation factor X
P00747 Plasminogen
P01215 Glycoprotein hormones alpha chain
P01563 Interferon alpha-2
P01588 Erythropoietin
P01824 Immunoglobulin heavy variable 4-39
P01876 Immunoglobulin heavy constant alpha 1
P01880 Immunoglobulin heavy constant delta
P02656 Apolipoprotein C-III
GlycoEpitope
Epitope ID
EP0023
GlycomeAtlas

Tissues in which this glycan is expressed are highlighted in yellow.

Danio rerio
Brain Gill Heart Intestine Intestine Liver Ovary Skin Testis
Literature
Tissue
  • brain
  • gill
  • heart
  • intestine
  • liver
  • skin gland
  • testis
Reference
Yamakawa N et al. Systems glycomics of adult zebrafish identifies organ-specific sialylation and glycosylation patterns. Nat Commun. 2018;9(1):4647. Published 2018 Nov 7. doi:10.1038/s41467-018-06950-3
DOI
10.1038/s41467-018-06950-3
Localization sites organized by hierarchy by Uber-anatomy ontology (UBERON)
Sequence Descriptors
GlycoCT
RES
1b:a-dgal-HEX-1:5
2s:n-acetyl
3b:b-dgal-HEX-1:5
4b:a-dgro-dgal-NON-2:6|1:a|2:keto|3:d
5s:n-acetyl
6b:a-dgro-dgal-NON-2:6|1:a|2:keto|3:d
7s:n-acetyl
LIN
1:1d(2+1)2n
2:1o(3+1)3d
3:3o(3+2)4d
4:4d(5+1)5n
5:1o(6+2)6d
6:6d(5+1)7n
WURCS
WURCS=2.0/3,4,3/[a2112h-1a_1-5_2*NCC/3=O][a2112h-1b_1-5][Aad21122h-2a_2-6_5*NCC/3=O]/1-2-3-3/a3-b1_a6-d2_b3-c2
Literature
Displaying entries 11 - 20 of 103 in total
PubMed ID Title First Author Publication Date Source
15701648 Potent Glycan Inhibitors of Myelin-associated Glycoprotein Enhance Axon Outgrowth in Vitro Vyas AA 2005 Apr 22
  • GlyGen
  • GlycoEpitope
15557177 The Glycosylation of Human Serum IgD and IgE and the Accessibility of Identified Oligomannose Structures for Interaction with Mannan-Binding Lectin Arnold JN 2004 Dec 01
  • GlyGen
  • PubChem
14673092 Murine and human zona pellucida 3 derived from mouse eggs express identical O-glycans Dell A 2003 Dec 12
  • GlyGen
  • PubChem
12000758 Recombinant MUC1 probe authentically reflects cell-specific O-glycosylation profiles of endogenous breast cancer mucin. High density and prevalent core 2-based glycosylation Muller S 2002 Jul 19
  • GlyGen
11294842 Structural elucidation of the N- and O-glycans of human apolipoprotein(a): role of o-glycans in conferring protease resistance Garner B 2001 Jun 22
  • GlyGen
  • PubChem
11805077 Structural analysis of sulfated N-linked oligosaccharides in erythropoietin Kawasaki N 2001 Dec
  • GlyGen
  • PubChem
11062056 Cloning, expression and gene organization of a human Neu5Ac alpha 2-3Gal beta 1-3GalNAc alpha 2,6-sialyltransferase: hST6GalNAcIV Harduin-Lepers A 2000 Nov 15
  • PubChem
10764840 Unusual N-glycosylation of a recombinant human erythropoietin expressed in a human lymphoblastoid cell line does not alter its biological properties Cointe D 2000 May
  • GlyGen
  • PubChem
10861392 Metabolic shifts do not influence the glycosylation patterns of a recombinant fusion protein expressed in BHK cells Cruz HJ 2000 Jul 20
  • GlyGen
  • PubChem
11123894 O-Glycan Analysis of Natural Human Neutrophil Gelatinase B Using a Combination of Normal Phase- HPLC and Online Tandem Mass Spectrometry: Implications for the Domain Organization of the Enzyme Mattu TS 2000 Dec 01
  • GlyGen
  • PubChem
PubAnnotation
Displaying all 4 entries
Title Authors Source Publication Date PubMed ID
Reduction in disialyl-T antigen levels in mice deficient for both St6galnac3 and St6galnac4 results in blood filling of lymph nodes.
  • Fuseya S
  • Izumi H
  • Hamano A
  • Murakami Y
  • Suzuki R
  • Koiwai R
  • Hayashi T
  • Kuno A
  • Takahashi S
  • Kudo T
 Sci Rep 2023 Jun 29 37386100
Mammalian sialyltransferases allow efficient Escherichia coli-based production of mucin-type O-glycoproteins but can also transfer Kdo.
  • Sim L
  • Thompson N
  • Geissner A
  • Withers SG
  • Wakarchuk WW
 Glycobiology 2022 Apr 21 34939113
Majority of alpha2,6-sialylated glycans in the adult mouse brain exist in O-glycans: SALSA-MS analysis for knockout mice of alpha2,6-sialyltransferase genes.
  • Ohmi Y
  • Nishikaze T
  • Kitaura Y
  • Ito T
  • Yamamoto S
  • Sugiyama F
  • Matsuyama M
  • Takahashi Y
  • Takeda A
  • Kawahara T
  • Okajima T
  • Furukawa K
  • Furukawa K
 Glycobiology 2021 Jun 3 33242079
Potent glycan inhibitors of myelin-associated glycoprotein enhance axon outgrowth in vitro.
  • Vyas AA
  • Blixt O
  • Paulson JC
  • Schnaar RL
 J Biol Chem 2005 Apr 22 15701648
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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: December 8, 2025