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ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 1

Summary

Gene Symbol

ST6GALNAC1

Aliases

ST6GalNAcI

Organism

Homo sapiens (human)

External Links

NCBI Gene

55808

GGDB ID

gg056

HGNC

23614

mRNA

NM_018414

map

17q25.1

Protein

NP_060884

OMIM

610138

KEGG Gene ID

hsa:55808

PubChem

55808

Alliance of Genome Resources

HGNC:23614

Annotation

Keyword

Disease variant
Disulfide bond
Glycoprotein
Glycosyltransferase
Golgi apparatus
Reference proteome
Signal-anchor
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
Q9NSC7	GalNAc alpha-2,6-sialyltransferase I ST6GalNAc I Sialyltransferase 7A

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 5** entries
GO Term	Evidence Code	PMID
protein glycosylation	NAS	10536037
protein glycosylation	IDA	16319059
protein glycosylation	IEA
oligosaccharide biosynthetic process	IBA
host-mediated regulation of intestinal microbiota composition	ISS

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation

biosynthetic process [inference]

organic substance biosynthetic process [inference]

carbohydrate biosynthetic process [inference]

oligosaccharide biosynthetic process

primary metabolic process [inference]

carbohydrate metabolic process [inference]

oligosaccharide metabolic process [inference]

oligosaccharide biosynthetic process

carbohydrate biosynthetic process [inference]

oligosaccharide biosynthetic process

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation

glycosylation [inference]

macromolecule glycosylation [inference]

protein glycosylation

organic substance metabolic process [inference]

carbohydrate metabolic process [inference]

oligosaccharide metabolic process [inference]

oligosaccharide biosynthetic process

carbohydrate biosynthetic process [inference]

oligosaccharide biosynthetic process

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation

macromolecule modification [inference]

protein modification process [inference]

protein glycosylation

macromolecule glycosylation [inference]

protein glycosylation

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation

organic substance biosynthetic process [inference]

carbohydrate biosynthetic process [inference]

oligosaccharide biosynthetic process

multicellular organismal process [inference]

multicellular organismal-level homeostasis [inference]

homeostasis of number of cells [inference]

host-mediated regulation of intestinal microbiota composition

homeostatic process [inference]

multicellular organismal-level homeostasis [inference]

homeostasis of number of cells [inference]

host-mediated regulation of intestinal microbiota composition

biological process involved in interspecies interaction between organisms [inference]

biological process involved in symbiotic interaction [inference]

biological process involved in interaction with symbiont [inference]

modulation by host of symbiont process [inference]

host-mediated regulation of intestinal microbiota composition

Displaying **all 2** entries
GO Term	Evidence Code	PMID
Golgi membrane	TAS
Golgi membrane	IDA	16319059 35303419

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

organelle membrane [inference]

bounding membrane of organelle [inference]

Golgi membrane

Displaying **all 5** entries
GO Term	Evidence Code	PMID
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity	TAS
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity	IDA	16319059 35303419
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity	IBA
protein binding	IPI	28514442 33961781 35156780
sialyltransferase activity	NAS	10536037

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

glycosyltransferase activity [inference]

sialyltransferase activity

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity

binding [inference]

protein binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Sialyltransferase

Functional Category

H: Coenzyme transport and metabolism
M: Cell wall/membrane/envelope biogenesis
T: Signal transduction mechanisms

Displaying **all 2** entries
Gene Ontology
sialyltransferase activity
transferase activity

Displaying **all 2** entries
InterPro
GT29-like superfamiliy
Glycosyl transferase family 29

Human Protein Atlas

ENSG00000070526

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

Data available from v23.0.proteinatlas.org. Image credit: Human Protein Atlas

GlycoGene Database (GGDB)

GGDB ID

gg056

Gene Symbol

ST6GALNAC1

Reactions

Displaying **all 5** entries
Donor	Acceptor	Reducing terminal(Acceptor)	Product	Reducing terminal(Product)	Reference
CMP-Neu5Ac	G65562ZE	Ser/Thr	G01614ZM	Ser/Thr	10536037
CMP-Neu5Ac	G57321FI	Ser/Thr	G36123IU	Ser/Thr	10536037
CMP-Neu5Ac	G00031MO	Ser/Thr	G56682BC	Ser/Thr	10536037
CMP-Neu5Ac	G94435QH	O-glycan Synthesis	G47180UC	O-glycan Synthesis
CMP-Neu5Ac	G57321FI	O-glycan Synthesis	G36123IU	O-glycan Synthesis

Displaying entries **1 - 5** of 9 in total

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Donor	Acceptor	Reducing terminal(Acceptor)	Product	Reducing terminal(Product)	Reference
CMP-Neu5Ac	G57321FI	[Ala-Thr(*)-Ala]2-7	G36123IU	[Ala-Thr(*)-Ala]2-7	10536037
CMP-Neu5Ac	G65562ZE	Ser/Thr	G01614ZM	Ser/Thr	10536037
CMP-Neu5Ac	G11647UD	O-glycan Synthesis	G19749DC	O-glycan Synthesis
CMP-Neu5Ac	G57321FI	Ser/Thr	G36123IU	Ser/Thr	10536037
CMP-Neu5Ac	G00031MO	Ser/Thr	G56682BC	Ser/Thr	10536037

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Donor	Acceptor	Reducing terminal(Acceptor)	Reference
CMP-Neu5Ac	G89026DU	O-glycan Synthesis
CMP-Neu5Ac	G21856LC	Cer	10536037
CMP-Neu5Ac	G14380OJ	O-glycan Synthesis
CMP-Neu5Ac	G76763LN	O-glycan Synthesis
CMP-Neu5Ac	G32723SL	O-glycan Synthesis

Orthologous Gene

Displaying **all 2** entries
Species	Protein	mRNA
Mus musculus	NP_035501	NM_011371
Rattus norvegicus	XP_221248	XM_221248

KEGG BRITE Database

Orthology

K03479

Name

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase (sialyltransferase 7A) [EC:2.4.3.3]

References

10788794

Reactions

Displaying **all 3** entries
KEGG Reaction	Enzyme	Acceptor	Product
R12704	2.4.3.3	G00031MO	G28694FA
R05911	2.4.3.3	G57321FI	G36123IU
R05914	2.4.3.3 2.4.3.7	G65562ZE	G01614ZM

Rhea

RHEA:11136

a β-D-galactosyl-(1→3)-N-acetyl-α-D-galactosaminyl derivative + CMP-N-acetyl-β-neuraminate

a β-D-galactosyl-(1→3)-[N-acetyl-α-neuraminyl-(2→6)]-N-acetyl-α-D-galactosaminyl derivative + H⁺ + CMP

Enzyme

2.4.3.3

PMID

LIPID MAPS Gene / Proteome Database

LMPD ID: LMP006325
Gene Name: ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1

Ortholog

Displaying entries **1 - 10** of 42 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Mus musculus	20445	ZFIN:ZDB-GENE-041014-161	MOUSE03989
Danio rerio	55808	ZFIN:ZDB-GENE-041014-161
Rattus norvegicus	287920	ZFIN:ZDB-GENE-041014-160	RATNO02003
Pan troglodytes	449516		PANTR15505
Danio rerio	564336	ZFIN:ZDB-GENE-041014-160
Bos taurus	618655		BOVIN13921
Macaca mulatta	707339		MACMU15778
Danio rerio	799868	ZFIN:ZDB-GENE-041014-161
Canis lupus familiaris	100049002		CANLF18414
Equus caballus	100058687		HORSE03820

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

Search Tools

Guidelines

Summary

External Links

Annotation

OrthoDB (Group)

GlycoGene Database (GGDB)

KEGG BRITE Database

LIPID MAPS Gene / Proteome Database

International Collaboration

Acknowledgements