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ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 1

Summary

Gene Symbol

ST6GALNAC1

Aliases

ST6GalNAcI

Organism

Homo sapiens (human)

External Links

NCBI Gene

55808

GGDB ID

gg056

HGNC

23614

mRNA

NM_018414

map

17q25.1

Protein

NP_060884

OMIM

610138

KEGG Gene ID

hsa:55808

PubChem

55808

Alliance of Genome Resources

HGNC:23614

Annotation

Keyword

Disease variant
Disulfide bond
Glycoprotein
Glycosyltransferase
Golgi apparatus
Reference proteome
Signal-anchor
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
Q9NSC7	GalNAc alpha-2,6-sialyltransferase I ST6GalNAc I Sialyltransferase 7A

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 3** entries
GO Term	Evidence Code	PMID
oligosaccharide biosynthetic process	IBA
host-mediated regulation of intestinal microbiota composition	ISS
protein glycosylation	IDA IEA NAS	10536037 16319059

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation

biosynthetic process [inference]

organic substance biosynthetic process [inference]

carbohydrate biosynthetic process [inference]

oligosaccharide biosynthetic process

primary metabolic process [inference]

carbohydrate metabolic process [inference]

oligosaccharide metabolic process [inference]

oligosaccharide biosynthetic process

carbohydrate biosynthetic process [inference]

oligosaccharide biosynthetic process

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation

glycosylation [inference]

macromolecule glycosylation [inference]

protein glycosylation

organic substance metabolic process [inference]

carbohydrate metabolic process [inference]

oligosaccharide metabolic process [inference]

oligosaccharide biosynthetic process

carbohydrate biosynthetic process [inference]

oligosaccharide biosynthetic process

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation

macromolecule modification [inference]

protein modification process [inference]

protein glycosylation

macromolecule glycosylation [inference]

protein glycosylation

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation

organic substance biosynthetic process [inference]

carbohydrate biosynthetic process [inference]

oligosaccharide biosynthetic process

multicellular organismal process [inference]

multicellular organismal-level homeostasis [inference]

homeostasis of number of cells [inference]

host-mediated regulation of intestinal microbiota composition

homeostatic process [inference]

multicellular organismal-level homeostasis [inference]

homeostasis of number of cells [inference]

host-mediated regulation of intestinal microbiota composition

biological process involved in interspecies interaction between organisms [inference]

biological process involved in symbiotic interaction [inference]

biological process involved in interaction with symbiont [inference]

modulation by host of symbiont process [inference]

host-mediated regulation of intestinal microbiota composition

Displaying 1 entry
GO Term	Evidence Code	PMID
Golgi membrane	IDA TAS	16319059 35303419

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

organelle membrane [inference]

bounding membrane of organelle [inference]

Golgi membrane

Displaying **all 3** entries
GO Term	Evidence Code	PMID
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity	IBA IDA TAS	16319059 35303419
protein binding	IPI	35156780
sialyltransferase activity	NAS	10536037

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

glycosyltransferase activity [inference]

sialyltransferase activity

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity

binding [inference]

protein binding

Gene Ontology information from NCBI Gene and UniProt.

Human Protein Atlas

ENSG00000070526

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

Data available from v23.0.proteinatlas.org. Image credit: Human Protein Atlas

GlycoGene Database (GGDB)

GGDB ID

gg056

Gene Symbol

ST6GALNAC1

Reactions

Displaying **all 4** entries
Donor	Acceptor	Product	Reference
CMP-Neu5Ac	G57321FI	G36123IU	10536037
CMP-Neu5Ac	G65562ZE	G01614ZM	10536037
CMP-Neu5Ac	G94435QH	G47180UC
CMP-Neu5Ac	G00031MO	G56682BC	10536037

Displaying **all 6** entries
Donor	Acceptor	Product	Reference
CMP-Neu5Ac	G00031MO	G56682BC	10536037
CMP-Neu5Ac	G11647UD	G19749DC
CMP-Neu5Ac	G65562ZE	G01614ZM	10536037
CMP-Neu5Ac	G57321FI	G36123IU	10536037
CMP-Neu5Ac	G94435QH	G47180UC
CMP-Neu5Ac	G00035MO	G63334FZ

Displaying **all 10** entries
Donor	Acceptor	Reference
CMP-Neu5Ac	G03277YI	10536037
CMP-Neu5Ac	G43946PN
CMP-Neu5Ac	G57321FI	10536037
CMP-Neu5Ac	G66367EU
CMP-Neu5Ac	G76763LN
CMP-Neu5Ac	G32723SL
CMP-Neu5Ac	G21856LC	10536037
CMP-Neu5Ac	G00924FH
CMP-Neu5Ac	G89026DU
CMP-Neu5Ac	G14380OJ

Orthologous Gene

Displaying **all 2** entries
Species	Protein	mRNA
Rattus norvegicus	XP_221248	XM_221248
Mus musculus	NP_035501	NM_011371

KEGG BRITE Database

Orthology

K03479

Name

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase (sialyltransferase 7A) [EC:2.4.3.3]

References

10788794

Reactions

Displaying **all 3** entries
KEGG Reaction	Enzyme	Acceptor	Product
R05911	2.4.3.3	G57321FI	G36123IU
R05914	2.4.3.3 2.4.3.7	G65562ZE	G01614ZM
R12704	2.4.3.3	G00031MO	G28694FA

Rhea

RHEA:11136

a β-D-galactosyl-(1→3)-N-acetyl-α-D-galactosaminyl derivative + CMP-N-acetyl-β-neuraminate

a β-D-galactosyl-(1→3)-[N-acetyl-α-neuraminyl-(2→6)]-N-acetyl-α-D-galactosaminyl derivative + H⁺ + CMP

Enzyme

2.4.3.3

PMID

Disease

Disease Ontology

Displaying entries **1 - 10** of 26 in total

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DO ID	Disease Name	Source
DOID:0050589	inflammatory bowel disease	DisGeNET Alliance of Genome Resources
DOID:0110892	inflammatory bowel disease 1	DisGeNET
DOID:10534	stomach cancer	DisGeNET
DOID:11054	urinary bladder cancer	DisGeNET DisGeNET
DOID:11847	coronary thrombosis	DisGeNET
DOID:1380	endometrial cancer	DisGeNET DisGeNET
DOID:1520	colon carcinoma	DisGeNET
DOID:1612	breast cancer	DisGeNET
DOID:162	cancer	DisGeNET DisGeNET
DOID:219	colon cancer	DisGeNET

LIPID MAPS Gene / Proteome Database

LMPD ID: LMP006325
Gene Name: ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1

Ortholog

Displaying entries **1 - 10** of 41 in total

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Last »
Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Danio rerio	564336	ZFIN:ZDB-GENE-041014-160
Danio rerio	799868	ZFIN:ZDB-GENE-041014-161
Callithrix jacchus	100394846		CALJA36364
Macaca fascicularis	102131184		MACFA14884
Macaca mulatta	707339		MACMU15778
Macaca nemestrina	105469211		MACNE15281
Mandrillus leucophaeus	105543234		MANLE00220
Gorilla gorilla gorilla	101131564		GORGO35111
Pan paniscus	100990954		PANPA18009
Pan troglodytes	449516		PANTR15505

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

All Resources

Other Information

Tools

Search Tools

Summary

External Links

Annotation

GlycoGene Database (GGDB)

KEGG BRITE Database

LIPID MAPS Gene / Proteome Database

International Collaboration

Acknowledgements