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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
MBL associated serine protease 2
Summary
- Gene Symbol
-
- MASP2
- Aliases
-
- MAP-2
- Map19
- mannose-binding lectin associated protein 19
- mannose-binding lectin-associated serine protease 2
- sMAP
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- 3D-structure
- Alternative splicing
- Autocatalytic cleavage
- Calcium
- Complement pathway
- Direct protein sequencing
- Disease variant
- Disulfide bond
- EGF-like domain
- Hydroxylation
- Metal-binding
- Proteomics identification
- Reference proteome
- Repeat
- Secreted
- Serine protease
- Signal
- Sushi
- Proteins
| UniProt | Protein Name |
|---|---|
| O00187 |
|
| A0A8V8TQY3 |
|
Gene Ontology (GO)
| GO Term | Evidence Code | PMID |
|---|---|---|
| proteolysis | ||
| complement activation, lectin pathway | ||
| complement activation, classical pathway |
GO Hierarchy
| GO Term | Evidence Code | PMID |
|---|---|---|
| extracellular region | ||
| extracellular space | ||
| extracellular exosome |
GO Hierarchy
| GO Term | Evidence Code | PMID |
|---|---|---|
| protein binding | ||
| complement component C4b binding | ||
| calcium-dependent protein binding | ||
| identical protein binding | ||
| peptidase activity |
GO Hierarchy
OrthoDB (Group)
- Group level
- Eukaryota
- Group Name
- Mannan-binding lectin serine protease 1
- Functional Category
-
- G: Carbohydrate transport and metabolism
- O: Posttranslational modification, protein turnover, chaperones
- T: Signal transduction mechanisms
KEGG BRITE Database
Disease
- The Human Phenotype Ontology
| HPO ID | HPO Term |
|---|---|
| HP:0000007 | Autosomal recessive inheritance |
| HP:0002725 | Systemic lupus erythematosus |
| HP:0004431 | Complement deficiency |
| HP:0004431 | Reduced circulating complement concentration |
| HP:0006532 | Recurrent pneumonia |
| HP:0100279 | Ulcerative colitis |
| Disease ID | Disease Name |
|---|---|
| OMIM:613791 |
|
PubChem Disease
- MedGen Diseases
- OMIM Phenotypes
- KEGG Diseases
Ortholog
| Species | Gene ID | OrthoDB | Alliance of Genome Resources | Orthologous MAtrix |
|---|---|---|---|---|
| 101126677 | 9595_0:000470 | |||
| 101597108 | JACJA08997 | |||
| 101678006 | MUSPF18612 | |||
| 101950973 | CHRPI32749 | |||
| 102131322 | MACFA23551 | |||
| 102169785 | CAPHI06802 | |||
| 102453425 | PELSI14461 | |||
| 103023364 | ASTMX04787 | |||
| 103252233 | CARSF23879 | |||
| 103733193 | NANGA15861 |
