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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
MBL associated serine protease 2
Summary
- Gene Symbol
-
- MASP2
- Aliases
-
- MAP-2
- Map19
- mannose-binding lectin associated protein 19
- mannose-binding lectin-associated serine protease 2
- sMAP
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- 3D-structure
- Alternative splicing
- Autocatalytic cleavage
- Calcium
- Complement pathway
- Direct protein sequencing
- Disease variant
- Disulfide bond
- EGF-like domain
- Hydroxylation
- Metal-binding
- Proteomics identification
- Reference proteome
- Repeat
- Secreted
- Serine protease
- Signal
- Sushi
- Proteins
| UniProt | Protein Name |
|---|---|
| O00187 |
|
| A0A8V8TQY3 |
|
Gene Ontology (GO)
| GO Term | Evidence Code | PMID |
|---|---|---|
| proteolysis | ||
| complement activation, lectin pathway | ||
| complement activation, classical pathway |
GO Hierarchy
| GO Term | Evidence Code | PMID |
|---|---|---|
| extracellular region | ||
| extracellular space | ||
| extracellular exosome |
GO Hierarchy
| GO Term | Evidence Code | PMID |
|---|---|---|
| protein binding | ||
| complement component C4b binding | ||
| calcium-dependent protein binding | ||
| identical protein binding | ||
| peptidase activity |
GO Hierarchy
OrthoDB (Group)
- Group level
- Eukaryota
- Group Name
- Mannan-binding lectin serine protease 1
- Functional Category
-
- G: Carbohydrate transport and metabolism
- O: Posttranslational modification, protein turnover, chaperones
- T: Signal transduction mechanisms
KEGG BRITE Database
Disease
- The Human Phenotype Ontology
| HPO ID | HPO Term |
|---|---|
| HP:0000007 | Autosomal recessive inheritance |
| HP:0002725 | Systemic lupus erythematosus |
| HP:0004431 | Complement deficiency |
| HP:0004431 | Reduced circulating complement concentration |
| HP:0006532 | Recurrent pneumonia |
| HP:0100279 | Ulcerative colitis |
| Disease ID | Disease Name |
|---|---|
| OMIM:613791 |
|
PubChem Disease
- MedGen Diseases
- OMIM Phenotypes
- KEGG Diseases
Ortholog
| Species | Gene ID | OrthoDB | Alliance of Genome Resources | Orthologous MAtrix |
|---|---|---|---|---|
| 104654364 | RHIRO33578 | |||
| 105294376 | PTEVA08398 | |||
| 105473143 | MACNE36810 | |||
| 105551392 | MANLE13073 | |||
| 105580873 | CERAT28963 | |||
| 105731700 | AOTNA20129 | |||
| 105824943 | PROCO07647 | |||
| 107974877 | 9598_0:0001a1 | PANTR19918 | ||
| 108276220 | ICTPU08117 | |||
| 108539381 | RHIBE13973 |
